Literature DB >> 20865143

REDUCING STRAY RADIATION DOSE FOR A PEDIATRIC PATIENT RECEIVING PROTON CRANIOSPINAL IRRADIATION.

Phillip J Taddei1, Dragan Mirkovic, Jonas D Fontenot, Annelise Giebeler, Yuanshui Zheng, Uwe Titt, Shiao Woo, Wayne D Newhauser.   

Abstract

The aim of this study was to quantify stray radiation dose from neutrons emanating from a proton treatment unit and to evaluate methods of reducing this dose for a pediatric patient undergoing craniospinal irradiation. The organ equivalent doses and effective dose from stray radiation were estimated for a 30.6-Gy treatment using Monte Carlo simulations of a passive scattering treatment unit and a patient-specific voxelized anatomy. The treatment plan was based on computed tomography images of a 10-yr-old male patient. The contribution to stray radiation was evaluated for the standard nozzle and for the same nozzle but with modest modifications to suppress stray radiation. The modifications included enhancing the local shielding between the patient and the primary external neutron source and increasing the distance between them. The effective dose from stray radiation emanating from the standard nozzle was 322 mSv; enhancements to the nozzle reduced the effective dose by as much as 43%. These results add to the body of evidence that modest enhancements to the treatment unit can reduce substantially the effective dose from stray radiation.

Entities:  

Year:  2009        PMID: 20865143      PMCID: PMC2943394          DOI: 10.13182/nt09-a9108

Source DB:  PubMed          Journal:  Nucl Technol        ISSN: 0029-5450


  11 in total

1.  Calculations of neutron dose equivalent exposures from range-modulated proton therapy beams.

Authors:  Jerimy C Polf; Wayne D Newhauser
Journal:  Phys Med Biol       Date:  2005-08-02       Impact factor: 3.609

2.  Monte Carlo simulations for configuring and testing an analytical proton dose-calculation algorithm.

Authors:  Wayne Newhauser; Jonas Fontenot; Yuanshui Zheng; Jerimy Polf; Uwe Titt; Nicholas Koch; Xiaodong Zhang; Radhe Mohan
Journal:  Phys Med Biol       Date:  2007-07-10       Impact factor: 3.609

3.  Monte Carlo study of neutron dose equivalent during passive scattering proton therapy.

Authors:  Yuanshui Zheng; Wayne Newhauser; Jonas Fontenot; Phil Taddei; Radhe Mohan
Journal:  Phys Med Biol       Date:  2007-06-27       Impact factor: 3.609

4.  Monte Carlo investigation of collimator scatter of proton-therapy beams produced using the passive scattering method.

Authors:  Uwe Titt; Yuanshui Zheng; Oleg N Vassiliev; Wayne D Newhauser
Journal:  Phys Med Biol       Date:  2007-12-28       Impact factor: 3.609

5.  Leakage and scatter radiation from a double scattering based proton beamline.

Authors:  M F Moyers; E R Benton; A Ghebremedhin; G Coutrakon
Journal:  Med Phys       Date:  2008-01       Impact factor: 4.071

6.  Can megavoltage computed tomography reduce proton range uncertainties in treatment plans for patients with large metal implants?

Authors:  Wayne D Newhauser; Annelise Giebeler; Katja M Langen; Dragan Mirkovic; Radhe Mohan
Journal:  Phys Med Biol       Date:  2008-04-17       Impact factor: 3.609

7.  Reducing stray radiation dose to patients receiving passively scattered proton radiotherapy for prostate cancer.

Authors:  Phillip J Taddei; Jonas D Fontenot; Yuanshui Zheng; Dragan Mirkovic; Andrew K Lee; Uwe Titt; Wayne D Newhauser
Journal:  Phys Med Biol       Date:  2008-03-27       Impact factor: 3.609

8.  Monte Carlo simulations of neutron spectral fluence, radiation weighting factor and ambient dose equivalent for a passively scattered proton therapy unit.

Authors:  Yuanshui Zheng; Jonas Fontenot; Phil Taddei; Dragan Mirkovic; Wayne Newhauser
Journal:  Phys Med Biol       Date:  2007-12-19       Impact factor: 3.609

9.  The risk of developing a second cancer after receiving craniospinal proton irradiation.

Authors:  Wayne D Newhauser; Jonas D Fontenot; Anita Mahajan; David Kornguth; Marilyn Stovall; Yuanshui Zheng; Phillip J Taddei; Dragan Mirkovic; Radhe Mohan; James D Cox; Shiao Woo
Journal:  Phys Med Biol       Date:  2009-03-20       Impact factor: 3.609

10.  Stray radiation dose and second cancer risk for a pediatric patient receiving craniospinal irradiation with proton beams.

Authors:  Phillip J Taddei; Dragan Mirkovic; Jonas D Fontenot; Annelise Giebeler; Yuanshui Zheng; David Kornguth; Radhe Mohan; Wayne D Newhauser
Journal:  Phys Med Biol       Date:  2009-03-20       Impact factor: 3.609

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  10 in total

1.  Predicted risks of second malignant neoplasm incidence and mortality due to secondary neutrons in a girl and boy receiving proton craniospinal irradiation.

Authors:  Phillip J Taddei; Anita Mahajan; Dragan Mirkovic; Rui Zhang; Annelise Giebeler; David Kornguth; Mark Harvey; Shiao Woo; Wayne D Newhauser
Journal:  Phys Med Biol       Date:  2010-11-12       Impact factor: 3.609

2.  Risk of second malignant neoplasm following proton versus intensity-modulated photon radiotherapies for hepatocellular carcinoma.

Authors:  Phillip J Taddei; Rebecca M Howell; Sunil Krishnan; Sarah B Scarboro; Dragan Mirkovic; Wayne D Newhauser
Journal:  Phys Med Biol       Date:  2010-11-12       Impact factor: 3.609

3.  Benchmark measurements and simulations of dose perturbations due to metallic spheres in proton beams.

Authors:  Wayne D Newhauser; Laura Rechner; Dragan Mirkovic; Pablo Yepes; Nicholas C Koch; Uwe Titt; Jonas D Fontenot; Rui Zhang
Journal:  Radiat Meas       Date:  2013-11-01       Impact factor: 1.898

Review 4.  Assessing the risk of second malignancies after modern radiotherapy.

Authors:  Wayne D Newhauser; Marco Durante
Journal:  Nat Rev Cancer       Date:  2011-05-19       Impact factor: 60.716

Review 5.  Determining Out-of-Field Doses and Second Cancer Risk From Proton Therapy in Young Patients-An Overview.

Authors:  Maite Romero-Expósito; Iuliana Toma-Dasu; Alexandru Dasu
Journal:  Front Oncol       Date:  2022-05-31       Impact factor: 5.738

6.  Low- and middle-income countries can reduce risks of subsequent neoplasms by referring pediatric craniospinal cases to centralized proton treatment centers.

Authors:  Phillip J Taddei; Nabil Khater; Bassem Youssef; Rebecca M Howell; Wassim Jalbout; Rui Zhang; Fady B Geara; Annelise Giebeler; Anita Mahajan; Dragan Mirkovic; Wayne D Newhauser
Journal:  Biomed Phys Eng Express       Date:  2018-02-07

7.  Analytical model for out-of-field dose in photon craniospinal irradiation.

Authors:  Phillip J Taddei; Wassim Jalbout; Rebecca M Howell; Nabil Khater; Fady Geara; Kenneth Homann; Wayne D Newhauser
Journal:  Phys Med Biol       Date:  2013-10-08       Impact factor: 3.609

8.  Monte Carlo simulation of the neutron spectral fluence and dose equivalent for use in shielding a proton therapy vault.

Authors:  Yuanshui Zheng; Wayne Newhauser; Eric Klein; Daniel Low
Journal:  Phys Med Biol       Date:  2009-11-04       Impact factor: 3.609

9.  Stray radiation dose and second cancer risk for a pediatric patient receiving craniospinal irradiation with proton beams.

Authors:  Phillip J Taddei; Dragan Mirkovic; Jonas D Fontenot; Annelise Giebeler; Yuanshui Zheng; David Kornguth; Radhe Mohan; Wayne D Newhauser
Journal:  Phys Med Biol       Date:  2009-03-20       Impact factor: 3.609

Review 10.  A Review of Radiotherapy-Induced Late Effects Research after Advanced Technology Treatments.

Authors:  Wayne D Newhauser; Amy Berrington de Gonzalez; Reinhard Schulte; Choonsik Lee
Journal:  Front Oncol       Date:  2016-02-10       Impact factor: 6.244

  10 in total

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