Literature DB >> 18364551

Aperture optimization in emission imaging using ideal observers for joint detection and localization.

Lili Zhou1, Parmeshwar Khurd, Santosh Kulkarni, Anand Rangarajan, Gene Gindi.   

Abstract

For the familiar 2-class detection problem (signal present/absent), ideal observers have been applied to optimization of pinhole and collimator parameters in planar emission imaging. Given photon noise and background and signal variabilities, such experiments show how to optimize an aperture to maximize detectability of the signal. Here, we consider a fundamentally different, more realistic task in which the observer is required to both detect and localize a signal. The signal is embedded in a variable background and is known except for location. We inquire whether the addition of a localization requirement changes conclusions on aperture optimization. We have previously formulated an ideal observer for this joint detection/localization task, and here apply it to the classic problem of determining an optimal pinhole diameter in a planar emission imaging system. We conclude that as search tolerance on localization decreases, the optimal pinhole diameter shrinks from that required by detection alone, and, in addition, task performance becomes more sensitive to fluctuations about the optimal pinhole diameter. As in the case for detection only, the optimal pinhole diameter shrinks as the amount of background variability grows and, in addition, conspicuity limits can be observed. Unlike the case for detection only, our task leads to a finite aperture size in the absence of background variability. For both tasks, the inclusion of background variability yields a finite aperture size.

Mesh:

Year:  2008        PMID: 18364551      PMCID: PMC2865200          DOI: 10.1088/0031-9155/53/8/002

Source DB:  PubMed          Journal:  Phys Med Biol        ISSN: 0031-9155            Impact factor:   3.609


  13 in total

1.  Ideal-observer computation in medical imaging with use of Markov-chain Monte Carlo techniques.

Authors:  Matthew A Kupinski; John W Hoppin; Eric Clarkson; Harrison H Barrett
Journal:  J Opt Soc Am A Opt Image Sci Vis       Date:  2003-03       Impact factor: 2.129

2.  A modified uniform Cramer-Rao bound for multiple pinhole aperture design.

Authors:  L J Meng; N H Clinthorne
Journal:  IEEE Trans Med Imaging       Date:  2004-07       Impact factor: 10.048

3.  Decision strategies that maximize the area under the LROC curve.

Authors:  Parmeshwar Khurd; Gene Gindi
Journal:  IEEE Trans Med Imaging       Date:  2005-12       Impact factor: 10.048

4.  Small nodule detectability evaluation using a generalized scan-statistic model.

Authors:  Lucreţiu M Popescu; Robert M Lewitt
Journal:  Phys Med Biol       Date:  2006-11-15       Impact factor: 3.609

5.  Spatial resolution and noise tradeoffs in pinhole imaging system design: a density estimation approach.

Authors:  J Fessler
Journal:  Opt Express       Date:  1998-03-16       Impact factor: 3.894

6.  Objective assessment of image quality: effects of quantum noise and object variability.

Authors:  H H Barrett
Journal:  J Opt Soc Am A       Date:  1990-07       Impact factor: 2.129

7.  Aperture optimization for emission imaging: effect of a spatially varying background.

Authors:  K J Myers; J P Rolland; H H Barrett; R F Wagner
Journal:  J Opt Soc Am A       Date:  1990-07       Impact factor: 2.129

Review 8.  Unified measurement of observer performance in detecting and localizing target objects on images.

Authors:  R G Swensson
Journal:  Med Phys       Date:  1996-10       Impact factor: 4.071

9.  A comparison of optimum detector spatial resolution in nuclear imaging based on statistical theory and on observer performance.

Authors:  B M Tsui; C E Metz; F B Atkins; S J Starr; R N Beck
Journal:  Phys Med Biol       Date:  1978-07       Impact factor: 3.609

10.  Efficiency of the human observer detecting random signals in random backgrounds.

Authors:  Subok Park; Eric Clarkson; Matthew A Kupinski; Harrison H Barrett
Journal:  J Opt Soc Am A Opt Image Sci Vis       Date:  2005-01       Impact factor: 2.129

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  4 in total

Review 1.  Task-based measures of image quality and their relation to radiation dose and patient risk.

Authors:  Harrison H Barrett; Kyle J Myers; Christoph Hoeschen; Matthew A Kupinski; Mark P Little
Journal:  Phys Med Biol       Date:  2015-01-07       Impact factor: 3.609

2.  SPECT system optimization against a discrete parameter space.

Authors:  L J Meng; N Li
Journal:  Phys Med Biol       Date:  2013-04-15       Impact factor: 3.609

3.  Optimal Joint Detection and Estimation That Maximizes ROC-Type Curves.

Authors:  Adam Wunderlich; Bart Goossens; Craig K Abbey
Journal:  IEEE Trans Med Imaging       Date:  2016-04-13       Impact factor: 10.048

4.  Collimator optimization in SPECT based on a joint detection and localization task.

Authors:  Lili Zhou; Gene Gindi
Journal:  Phys Med Biol       Date:  2009-06-26       Impact factor: 3.609

  4 in total

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