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Literature DB >> 6969686

Pi M4: an additional Pi M subtype.

Abstract

The authors studied Pi polymorphism using the Separator isofocusing method with slight modification. A new Pi allele was observed. Family pedigrees confirmed co-dominant inheritance with other Pi alleles. According to the electrophoretic mobility of its isoprotein bands, and to its frequency (0.04) this new allele is considered as a fourth Pi M subtype: Pi M4.

Mesh：

Substances：
alpha 1-Antitrypsin

Year: 1980 PMID： 6969686 DOI： 10.1007/BF00329137

Source DB: PubMed Journal: Hum Genet ISSN： 0340-6717 Impact factor: 4.132

11 in total

1. Pi (antitrypsin) typing methods. A comparison of acid starch-gel electrophoresis and isoelectric focusing.

Authors: A M Ward; J D Pickering; M K Fagerhol; J P Martin
Journal: Hum Hered Date: 1977 Impact factor: 0.444

2. Analysis of plasma 1 -antitrypsin variants and their microheterogeneity.

Authors: C B Laurell; U Persson
Journal: Biochim Biophys Acta Date: 1973-06-15

3. Serum prealbumin: polymorphism in man.

Authors: M K Fagerhol; M Braend
Journal: Science Date: 1965-08-27 Impact factor: 47.728

4. Reliable classification of six Pi M subtypes by separator isoelectric focusing.

Authors: R R Frants; A W Eriksson
Journal: Hum Hered Date: 1978 Impact factor: 0.444

5. Identification of alpha 1-antitrypsin variants.

Authors: A Yoshida
Journal: Am J Hum Genet Date: 1979-09 Impact factor: 11.025

6. Genetic variation of alpha 1-antitrypsin.

Authors: D W Cox
Journal: Am J Hum Genet Date: 1978-11 Impact factor: 11.025

7. Group-specific component. Report on the First International Workshop, Collège de France--July 27-28, 1978--Paris.

Authors: J Constans; H Cleve
Journal: Hum Genet Date: 1979-04-27 Impact factor: 4.132

8. Alpha 1 antitrypsin M1: a new common genetically determined variant.

Authors: F Kueppers
Journal: Am J Hum Genet Date: 1976-07 Impact factor: 11.025

9. Inheritance of PiM subtypes. A study of 151 families with a total of 242 children and of 142 mother-child pairs.

Authors: H Cleve; W Patutschnick; K Strecker; S Nevo
Journal: Hum Hered Date: 1979 Impact factor: 0.444

10. Characterization of alpha-1-antitrypsin by isoelectric focusing on an ultrathin polyacrylamide gel layer. An economic high-resolution system for determining PiM subtypes.

Authors: G Massi; A Fabiano; D Ragusa; P Auconi
Journal: Hum Genet Date: 1979 Impact factor: 4.132

16 in total

7. Alpha-1-antitrypsin (alpha 1AT) phenotypes and PiM subtypes in Italy. Evidence of considerable geographic variability.

Authors: G Massi; R Cotumaccio; P Auconi
Journal: Hum Genet Date: 1982 Impact factor: 4.132

Pi M4: an additional Pi M subtype.

1. Pi (antitrypsin) typing methods. A comparison of acid starch-gel electrophoresis and isoelectric focusing.

2. Analysis of plasma 1 -antitrypsin variants and their microheterogeneity.

3. Serum prealbumin: polymorphism in man.

4. Reliable classification of six Pi M subtypes by separator isoelectric focusing.

5. Identification of alpha 1-antitrypsin variants.

6. Genetic variation of alpha 1-antitrypsin.

7. Group-specific component. Report on the First International Workshop, Collège de France--July 27-28, 1978--Paris.

8. Alpha 1 antitrypsin M1: a new common genetically determined variant.

9. Inheritance of PiM subtypes. A study of 151 families with a total of 242 children and of 142 mother-child pairs.

10. Characterization of alpha-1-antitrypsin by isoelectric focusing on an ultrathin polyacrylamide gel layer. An economic high-resolution system for determining PiM subtypes.

1. Characterization of the molecular basis of the alpha 1-antitrypsin F allele.

2. Characterization of the gene and protein of the common alpha 1-antitrypsin normal M2 allele.

3. Improved resolution of PI (alpha 1-antitrypsin) phenotypes by a large-scale immobilized pH gradient.

4. Distribution of the Pi, TfC, and Gc subtypes in Galicia (North West Spain).

5. Alpha1-antitrypsin: evidence for a fourth PiM allele. Distribution of the PiM subtypes in Southern Germany.

6. PI(alpha 1-antitrypsin) polymorphism in the Japanese: confirmation of PI*M4 and description of new PI variants.

7. Alpha-1-antitrypsin (alpha 1AT) phenotypes and PiM subtypes in Italy. Evidence of considerable geographic variability.

8. Three new rare variants of alpha 1-antitrypsin.

9. PI (alpha 1-Antitrypsin) subtypes: frequency of PI*M4 in several populations.

10. Alpha-1-antitrypsin: evidence for a fifth PI M subtype and a new deficiency allele PI*Z augsburg.