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Literature DB >> 6984414

PI (alpha 1-Antitrypsin) subtypes: frequency of PI*M4 in several populations.

Abstract

Sera from different populations (Dutch, Northern and Southern Italians and Spaniards) were screened for PI (alpha 1-antitrypsin) types and subtypes. A polyacrylamide isoelectric focusing method was applied, which consisted of the combined use of an ultra-thin highly cross-linked gel, restricted pH range carrier ampholytes and a separator. This technique enabled easy typing and subtyping of all known PI phenotypes including PI*M subtypes. The frequency of the new PI*M4 allele was lowest of all PI*M alleles (0.0476 in The Netherlands, 0.0371 in Northern Italy, 0.0308 in Southern Italy and 0.0146 in Spain).

Entities: Chemical Gene

Mesh：

Substances：
alpha 1-Antitrypsin

Year: 1982 PMID： 6984414 DOI： 10.1007/BF00282302

Source DB: PubMed Journal: Hum Genet ISSN： 0340-6717 Impact factor: 4.132

22 in total

1. Genetic variants of serum alpha1-antitrypsin (Pi types) in Portuguese.

Authors: J P Martin; R Sesboue; R Charlionet; C Ropartz; M T Pereira
Journal: Hum Hered Date: 1976 Impact factor: 0.444

2. Pi phenotypes in Greeks.

Authors: A Fertakis; A Tsourapas; D Douratsos; B Angelopoulos
Journal: Hum Hered Date: 1974 Impact factor: 0.444

3. Isoelectric focusing of proteins in polyacrylamide gels.

Authors: O Vesterberg
Journal: Biochim Biophys Acta Date: 1972-01-26

4. Cirrhosis associated with alpha-1-antitrypsin deficiency: a previously unrecognized inherited disorder.

Authors: H L Sharp; R A Bridges; W Krivit; E F Freier
Journal: J Lab Clin Med Date: 1969-06

5. Serum Pi types in some European, American, Asian and African populations.

Authors: M K Fagerhol; O W Tenfjord
Journal: Acta Pathol Microbiol Scand Date: 1968

6. Phenotype and gene distribution of alpha-1-antitrypsin in a North Italian population.

Authors: E C Klasen; F D'Andrea; L F Bernini
Journal: Hum Hered Date: 1978 Impact factor: 0.444

7. Population genetics of alpha1-antitrypsin in the Netherlands. Description of a new electrophoretic variant.

Authors: E C Klasen; C Franken; W S Volkers; L F Bernini
Journal: Hum Genet Date: 1977-07-26 Impact factor: 4.132

8. Alpha 1-antitrypsin in patients with hepatocellular carcinoma and chronic active hepatitis.

Authors: S Fargion; E C Klasen; F Lalatta; G Sangalli; M Tommasini; G Fiorelli
Journal: Clin Genet Date: 1981-02 Impact factor: 4.438

9. alpha 1-Antitrypsin and coeliac disease in spain.

Authors: E C Klasen; I Polanco; I Biemond; C Vazquez; A S Peña
Journal: Gut Date: 1980-11 Impact factor: 23.059

10. Synthesis of highly diversified carrier ampholytes. Evaluation of the resolving power of isoelectric focusing in the Pi system (alpha-1-antitrypsin genetic polymorphism).

Authors: R Charlionet; J P Martin; R Sesboüé; P J Madec; F Lefebvre
Journal: J Chromatogr Date: 1979-08-01

5 in total

PI (alpha 1-Antitrypsin) subtypes: frequency of PI*M4 in several populations.

1. Genetic variants of serum alpha1-antitrypsin (Pi types) in Portuguese.

2. Pi phenotypes in Greeks.

3. Isoelectric focusing of proteins in polyacrylamide gels.

4. Cirrhosis associated with alpha-1-antitrypsin deficiency: a previously unrecognized inherited disorder.

5. Serum Pi types in some European, American, Asian and African populations.

6. Phenotype and gene distribution of alpha-1-antitrypsin in a North Italian population.

7. Population genetics of alpha1-antitrypsin in the Netherlands. Description of a new electrophoretic variant.

8. Alpha 1-antitrypsin in patients with hepatocellular carcinoma and chronic active hepatitis.

9. alpha 1-Antitrypsin and coeliac disease in spain.

10. Synthesis of highly diversified carrier ampholytes. Evaluation of the resolving power of isoelectric focusing in the Pi system (alpha-1-antitrypsin genetic polymorphism).

1. Does the PI polymorphism alone control alpha-1-antitrypsin expression?

2. The alpha 1 antitrypsin variant PI WFINNEYTOWN in a family of Caucasian origin.

3. PI(alpha 1-antitrypsin) polymorphism in the Japanese: confirmation of PI*M4 and description of new PI variants.

4. Alpha-1-antitrypsin: evidence for a fifth PI M subtype and a new deficiency allele PI*Z augsburg.

5. Geographical variability of alpha-1-antitrypsin alleles in China: a study on six Chinese populations.