Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Alpha-1-antitrypsin (alpha 1AT) phenotypes and PiM subtypes in Italy. Evidence of considerable geographic variability.

Literature DB >> 6982216

Alpha-1-antitrypsin (alpha 1AT) phenotypes and PiM subtypes in Italy. Evidence of considerable geographic variability.

Abstract

Genetic typing of alpha 1AT was performed in 3751 individuals from Italian towns. The following was observed: (a) The pathologic phenotypes (SZ, MZ, ZZ) appeared to decrease progressively from northern to southern Italy; (b) the distribution of the PiM suballeles showed considerable geographic variability, but the suballele M2 was more frequently encountered in southern Italy; and (c) in the large cities of southern Italy, the frequency of the deficiency more closely resembled that found in northern Italy than that of the remaining populations of the south.

Entities: Gene

Mesh：

Substances：
alpha 1-Antitrypsin

Year: 1982 PMID： 6982216 DOI： 10.1007/BF00291340

Source DB: PubMed Journal: Hum Genet ISSN： 0340-6717 Impact factor: 4.132

12 in total

1. The polymorphism of "prealbumins" and alpha-1-antitrypsin in human sera.

Authors: M K Fagerhol; C B Laurell
Journal: Clin Chim Acta Date: 1967-05 Impact factor: 3.786

2. Serum Pi types in some European, American, Asian and African populations.

Authors: M K Fagerhol; O W Tenfjord
Journal: Acta Pathol Microbiol Scand Date: 1968

3. Phenotype and gene distribution of alpha-1-antitrypsin in a North Italian population.

Authors: E C Klasen; F D'Andrea; L F Bernini
Journal: Hum Hered Date: 1978 Impact factor: 0.444

4. Genetic variation of alpha 1-antitrypsin.

Authors: D W Cox
Journal: Am J Hum Genet Date: 1978-11 Impact factor: 11.025

5. The genetics of alpha1-antitrypsin: a family study in England and Scotland.

Authors: P J Cook
Journal: Ann Hum Genet Date: 1975-01 Impact factor: 1.670

6. Determination of alpha-1-antitrypsin subtypes in the population of Rome: a study in ultrathin-layer isoelectric focusing.

Authors: V L Pascali; D De Mercurio
Journal: Hum Hered Date: 1981 Impact factor: 0.444

7. Genetic variations of serum alpha-1-antitrypsin (Pi types) in Normans. Common Pi M subtypes and new phenotypes.

Authors: R Charlionet; R Sesboüe; C Morcamp; F Lefebvre; J P Martin
Journal: Hum Hered Date: 1981 Impact factor: 0.444

8. Pi M4: an additional Pi M subtype.

Authors: J Constans; M Viau; C Gouaillard
Journal: Hum Genet Date: 1980 Impact factor: 4.132

9. Characterization of alpha-1-antitrypsin by isoelectric focusing on an ultrathin polyacrylamide gel layer. An economic high-resolution system for determining PiM subtypes.

Authors: G Massi; A Fabiano; D Ragusa; P Auconi
Journal: Hum Genet Date: 1979 Impact factor: 4.132

10. Synthesis of highly diversified carrier ampholytes. Evaluation of the resolving power of isoelectric focusing in the Pi system (alpha-1-antitrypsin genetic polymorphism).

Authors: R Charlionet; J P Martin; R Sesboüé; P J Madec; F Lefebvre
Journal: J Chromatogr Date: 1979-08-01

5 in total

Alpha-1-antitrypsin (alpha 1AT) phenotypes and PiM subtypes in Italy. Evidence of considerable geographic variability.

1. The polymorphism of "prealbumins" and alpha-1-antitrypsin in human sera.

2. Serum Pi types in some European, American, Asian and African populations.

3. Phenotype and gene distribution of alpha-1-antitrypsin in a North Italian population.

4. Genetic variation of alpha 1-antitrypsin.

5. The genetics of alpha1-antitrypsin: a family study in England and Scotland.

6. Determination of alpha-1-antitrypsin subtypes in the population of Rome: a study in ultrathin-layer isoelectric focusing.

7. Genetic variations of serum alpha-1-antitrypsin (Pi types) in Normans. Common Pi M subtypes and new phenotypes.

8. Pi M4: an additional Pi M subtype.

9. Characterization of alpha-1-antitrypsin by isoelectric focusing on an ultrathin polyacrylamide gel layer. An economic high-resolution system for determining PiM subtypes.

10. Synthesis of highly diversified carrier ampholytes. Evaluation of the resolving power of isoelectric focusing in the Pi system (alpha-1-antitrypsin genetic polymorphism).

1. Passive smoking and lung function in alpha(1)-antitrypsin heterozygote schoolchildren.

Review 2. Association of alpha 1-antitrypsin deficiency with lung and liver diseases.

3. Geographical variability of alpha-1-antitrypsin alleles in China: a study on six Chinese populations.

Review 4. A Review of Alpha-1 Antitrypsin Binding Partners for Immune Regulation and Potential Therapeutic Application.

Review 5. Alpha-1-antitrypsin: A possible host protective factor against Covid-19.