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Literature DB >> 6611289

PI(alpha 1-antitrypsin) polymorphism in the Japanese: confirmation of PI*M4 and description of new PI variants.

I Yuasa, K Suenaga, Y Gotoh, K Ito, N Yokoyama, K Okada.

Abstract

PI phenotyping by separator isoelectric focusing (SIEF) was performed on a total of 1000 unrelated Japanese individuals from two different areas of Western Japan. The PI M1M4 subtype was observed together with the six common PI M subtypes. PI*M4 was confirmed to be present but rare in the Japanese. Several new PI variants were identified by comparison runs of each variant with previously reported genetic variants. The significance of treatment of serum with dithiothreitol (DTT) followed by iodacetic acid (IAC) in determination of PI variants is also described.

Entities: Chemical Gene

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Year: 1984 PMID： 6611289 DOI： 10.1007/bf00273002

Source DB: PubMed Journal: Hum Genet ISSN： 0340-6717 Impact factor: 4.132

19 in total

1. alpha-1 Antitrypsin phenotypes determined by isoelectric focusing of the cysteine-antitrypsin mixed disulfide in serum.

Authors: J A Pierce; J O Jeppsson; C B Laurell
Journal: Anal Biochem Date: 1976-07 Impact factor: 3.365

2. Investigations on the population genetics of the alpha-1-antitrypsin polymorphism.

Authors: G Kellermann; H Walter
Journal: Humangenetik Date: 1970-09-17

3. Serum prealbumin: polymorphism in man.

Authors: M K Fagerhol; M Braend
Journal: Science Date: 1965-08-27 Impact factor: 47.728

4. Report of Nomenclature Meeting for alpha 1-antitrypsin, INSERM, Rouen/Bois-Guillaume-1978.

Authors: D W Cox; A M Johnson; M K Fagerhol
Journal: Hum Genet Date: 1980 Impact factor: 4.132

5. Reliable classification of six Pi M subtypes by separator isoelectric focusing.

Authors: R R Frants; A W Eriksson
Journal: Hum Hered Date: 1978 Impact factor: 0.444

6. Population genetics of alpha1-antitrypsin in the Netherlands. Description of a new electrophoretic variant.

Authors: E C Klasen; C Franken; W S Volkers; L F Bernini
Journal: Hum Genet Date: 1977-07-26 Impact factor: 4.132

7. Haptoglobin, group-specific component, transferrin and alpha 1-antitrypsin subtypes and new variants in Japanese.

Authors: K Shibata
Journal: Jinrui Idengaku Zasshi Date: 1983-03

8. Alpha1-antitrypsin: evidence for a fourth PiM allele. Distribution of the PiM subtypes in Southern Germany.

Authors: S Weidinger; H Cleve; W Patutschnick
Journal: Z Rechtsmed Date: 1982

9. New variants of alpha 1-antitrypsin: comparison of Pi typing techniques.

Authors: D W Cox
Journal: Am J Hum Genet Date: 1981-05 Impact factor: 11.025

10. Three new rare variants of alpha 1-antitrypsin.

Authors: D W Cox; S Smyth; G Billingsley
Journal: Hum Genet Date: 1982 Impact factor: 4.132

5 in total

Review 1. Pharmacogenetics and ecogenetics.

Authors: D P Agarwal; H W Goedde
Journal: Experientia Date: 1986-10-15

2. A new alpha 1-antitrypsin allele PI Poki: isoelectric focusing with immobilized pH gradients as a tool for identification for PI variants.

Authors: I Yuasa; K Okada
Journal: Hum Genet Date: 1985 Impact factor: 4.132