Literature DB >> 1085106

Alpha 1 antitrypsin M1: a new common genetically determined variant.

F Kueppers.   

Abstract

A new common variant (M1) of alpha 1 antitrypsin was detected by isoelectric focusing of serum in a pH gradient of 3.5-5.0 in polyacrylamide gels. The variant can be clearly distinguished from the common M type only when alpha 1 antitrypsin M is present in the same serum. It cannot be recognized on starch gel electrophoresis. The gene frequency in a population sample of United States whites was .09.

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Year:  1976        PMID： 1085106      PMCID： PMC1685061     

Source DB:  PubMed          Journal:  Am J Hum Genet        ISSN： 0002-9297            Impact factor:   11.025


  5 in total

1.  Genetic typing of alpha1-antitrypsin by immunofixation electrophoresis, identification of subtypes of Pi M.

Authors:  A M Johnson
Journal:  J Lab Clin Med       Date:  1976-01

2.  Protein measurement with the Folin phenol reagent.

Authors:  O H LOWRY; N J ROSEBROUGH; A L FARR; R J RANDALL
Journal:  J Biol Chem       Date:  1951-11       Impact factor: 5.157

3.  Serum Pi types in some European, American, Asian and African populations.

Authors:  M K Fagerhol; O W Tenfjord
Journal:  Acta Pathol Microbiol Scand       Date:  1968

4.  A new method for determination of alpha-1-antitrypsin phenotypes using isoelectric focusing on polyacrylamide gel slabs.

Authors:  R C Allen; R A Harley; R C Talamo
Journal:  Am J Clin Pathol       Date:  1974-12       Impact factor: 2.493

Review 5.  Alpha1-antitrypsin and its deficiency.

Authors:  F Kueppers; L F Black
Journal:  Am Rev Respir Dis       Date:  1974-08
  5 in total
  13 in total

1.  New phenotypes of serum alpha1-antitrypsin in Japanese detected by gel slab isoelectric focusing.

Authors:  S Harada; K Miyake; H Suzuki; T Oda
Journal:  Hum Genet       Date:  1977-10-14       Impact factor: 4.132

2.  Alpha1-antitrypsin: further genetic heterogeneity revealed by isoelectric focusing.

Authors:  F Kueppers; M J Christopherson
Journal:  Am J Hum Genet       Date:  1978-07       Impact factor: 11.025

3.  Classification of alpha1-antitrypsin (Pi) phenotypes by isoelectrofocusing. Distinction of six subtypes of the PiM phenotype.

Authors:  T Genz; J P Martin; H Cleve
Journal:  Hum Genet       Date:  1977-10-14       Impact factor: 4.132

4.  Origin of the multiple components of human alpha1-antitrypsin.

Authors:  A Yoshida; M Wessels
Journal:  Biochem Genet       Date:  1978-08       Impact factor: 1.890

5.  Polymorphism of the A subunit of coagulation factor XIII: evidence for subtypes of the FXIIIA*1 and FXIIIA*2 alleles.

Authors:  K Suzuki; K Matsui; S Ito; K Fujita; H Matsumoto
Journal:  Am J Hum Genet       Date:  1988-08       Impact factor: 11.025

6.  Improved resolution of PI (alpha 1-antitrypsin) phenotypes by a large-scale immobilized pH gradient.

Authors:  A Görg; W Postel; J Weser; W Patutschnick; H Cleve
Journal:  Am J Hum Genet       Date:  1985-09       Impact factor: 11.025

7.  Structural difference between the normal PiM1 and the common PiM2 variant of human alpha 1-antitrypsin.

Authors:  A Yoshida; J C Taylor; W G van den Brock
Journal:  Am J Hum Genet       Date:  1979-09       Impact factor: 11.025

8.  Characterization of alpha-1-antitrypsin by isoelectric focusing on an ultrathin polyacrylamide gel layer. An economic high-resolution system for determining PiM subtypes.

Authors:  G Massi; A Fabiano; D Ragusa; P Auconi
Journal:  Hum Genet       Date:  1979       Impact factor: 4.132

9.  Pi subtyping by isoelectric focusing: further genetic studies and application to paternity examinations.

Authors:  S Weidinger; F Schwarzfischer; H Cleve
Journal:  Z Rechtsmed       Date:  1980

10.  New variants of alpha 1-antitrypsin: comparison of Pi typing techniques.

Authors:  D W Cox
Journal:  Am J Hum Genet       Date:  1981-05       Impact factor: 11.025
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