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Literature DB >> 6605008

Distribution of the Pi, TfC, and Gc subtypes in Galicia (North West Spain).

Abstract

Alpha 1-antitrypsin (Pi), Gc, and TfC subtypes were determined by isoelectric focusing in thin layer agarose (AGIF) and polyacrylamide gels (PAGIF) in a total of 480 individuals from Galicia. The following gene frequencies were observed: for Pi:PiM1:0.660; PiM2:0.115; PiM3:0.060; PiS:0.149; PiZ:0.009; PiF:0.005; PiI:0.001; for Gc:Gc1S:0.572; Gc1F:0.120; Gc2:0.308; for TfC: TfC1:0.778; TfC2:0.180; TfC3:0.041; TfC6:0.001. A rare variant TfC6-2 was found and the intrafamilial distribution of the TfC6 allele studied. The use of these systems for forensic purposes and the peculiar distribution of some of their alleles in the Galician population are discussed.

Entities: Chemical Gene

Mesh：

Substances：
alpha 1-Antitrypsin

Year: 1983 PMID： 6605008 DOI： 10.1007/bf02092300

Source DB: PubMed Journal: Z Rechtsmed ISSN： 0044-3433

13 in total

1. Population genetic studies of serum protein polymorphisms in four Spanish populations. II.

Authors: H W Goedde; L Hirth; H G Benkmann; A Pellicer; T Pellicer; M Stahn; S Singh
Journal: Hum Hered Date: 1973 Impact factor: 0.444

2. A third common allele in the transferrin system, TfC3, detected by isoelectric focusing.

Authors: P Kühnl; W Spielmann
Journal: Hum Genet Date: 1979 Impact factor: 4.132

3. Population genetics of alpha1-antitrypsin in the Netherlands. Description of a new electrophoretic variant.

Authors: E C Klasen; C Franken; W S Volkers; L F Bernini
Journal: Hum Genet Date: 1977-07-26 Impact factor: 4.132

4. The typing of alpha 1-antitrypsin in human bloodstains by isoelectric focusing.

Authors: A Carracedo; L Concheiro
Journal: Forensic Sci Int Date: 1982 Mar-Apr Impact factor: 2.395

5. Pi M4: an additional Pi M subtype.

Authors: J Constans; M Viau; C Gouaillard
Journal: Hum Genet Date: 1980 Impact factor: 4.132

6. Alpha1-antitrypsin: evidence for a fourth PiM allele. Distribution of the PiM subtypes in Southern Germany.

Authors: S Weidinger; H Cleve; W Patutschnick
Journal: Z Rechtsmed Date: 1982

7. Group-specific component: evidence for two subtypes of the Gc1 gene.

Authors: J Constans; M Viau
Journal: Science Date: 1977-12-09 Impact factor: 47.728

8. A new procedure for the determination of transferrin C (Tf C) subtypes by isoelectric focusing. Existence of two additional alleles, Tf C4 and Tf C5.

Authors: J Constans; P Kühnl; M Viau; W Spielmann
Journal: Hum Genet Date: 1980 Impact factor: 4.132

Distribution of the Pi, TfC, and Gc subtypes in Galicia (North West Spain).

1. Population genetic studies of serum protein polymorphisms in four Spanish populations. II.

2. A third common allele in the transferrin system, TfC3, detected by isoelectric focusing.

3. Population genetics of alpha1-antitrypsin in the Netherlands. Description of a new electrophoretic variant.

4. The typing of alpha 1-antitrypsin in human bloodstains by isoelectric focusing.

5. Pi M4: an additional Pi M subtype.

6. Alpha1-antitrypsin: evidence for a fourth PiM allele. Distribution of the PiM subtypes in Southern Germany.

7. Group-specific component: evidence for two subtypes of the Gc1 gene.

8. A new procedure for the determination of transferrin C (Tf C) subtypes by isoelectric focusing. Existence of two additional alleles, Tf C4 and Tf C5.

9. Immunofixation. I. General principles and application to agarose gel electrophoresis.

10. Transferrin: evidence for two common subtypes of the TfC allele.

1. Group-specific component (GC) polymorphism in Cádiz (southern Spain).

2. Plasma protein and red cell enzyme groups in Galicia (north west Spain).

3. Transferrin gene frequencies in Cádiz (southern Spain).

Review 4. Alpha1-antitrypsin deficiency. 1: epidemiology of alpha1-antitrypsin deficiency.

5. The prevalence of alpha-1 antitrypsin deficiency in Ireland.