Literature DB >> 475360

Characteristics of herpesvirus mutants resistant to phosphonoformate and phosphonoacetate.

B Eriksson, B Oberg.   

Abstract

Mutants of herpes simplex virus type 1, resistant to phosphonoformate (PFA) and phosphonoacetate (PAA), have been selected in cell culture. The PFA-resistant mutant (HSV-PFA(r)) and the PAA-resistant mutant (HSV-PAA(r)) were also resistant to PAA and PFA, respectively. This cross-resistance indicates that PFA and PAA interact at the same site. The HSV-PFA(r) had a decreased susceptibility to vidarabine, but no difference in sensitivity to idoxuridine (5-iodo-2'-deoxyuridine) was observed when compared to the wild type. The induced deoxyribonucleic acid polymerases isolated from cells infected with HSV-PFA(r) and HSV-PAA(r) were both cross-resistant to inhibition by PFA and PAA. No increased resistance to vidarabine triphosphate could be observed, but the susceptibility to inhibition by pyrophosphate was about two times lower. None of the mutants showed any increased temperature sensitivity

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Year:  1979        PMID： 475360      PMCID： PMC352754          DOI： 10.1128/AAC.15.6.758

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  15 in total

1.  CELL CULTURE STUDIES ON ANTIVIRAL AGENTS. I. ACTION OF CYTOSINE ARABINOSIDE AND SOME COMPARISONS WITH 5-IODO-2-DEOXYURIDINE.

Authors:  D A BUTHALA
Journal:  Proc Soc Exp Biol Med       Date:  1964-01

2.  Trisodium phosphonoformate, a new antiviral compound.

Authors:  E Helgstrand; B Eriksson; N G Johansson; B Lannerö; A Larsson; A Misiorny; J O Norén; B Sjöberg; K Stenberg; G Stening; S Stridh; B Oberg
Journal:  Science       Date:  1978-09-01       Impact factor: 47.728

3.  Characteristics of herpes simplex virus resistance to disodium phosphonoacetate.

Authors:  R G Duff; E E Robishaw; J C Mao; L R Overby
Journal:  Intervirology       Date:  1978       Impact factor: 1.763

4.  Inhibition of herpesvirus replication and herpesvirus-induced deoxyribonucleic acid polymerase by phosphonoformate.

Authors:  J M Reno; L F Lee; J A Boezi
Journal:  Antimicrob Agents Chemother       Date:  1978-02       Impact factor: 5.191

5.  Nonstructural proteins of herpes simplex virus. I. Purification of the induced DNA polymerase.

Authors:  K L Powell; D J Purifoy
Journal:  J Virol       Date:  1977-11       Impact factor: 5.103

6.  Therapeutic effect of trisodium phosphonoformate on cutaneous herpesvirus infection in guinea pigs.

Authors:  S Alenius; Z Dinter; B Oberg
Journal:  Antimicrob Agents Chemother       Date:  1978-09       Impact factor: 5.191

7.  A working hypothesis--virus resistance development as an indicator of specific antiviral activity.

Authors:  E C Herrmann; J A Herrmann
Journal:  Ann N Y Acad Sci       Date:  1977-03-04       Impact factor: 5.691

8.  Genetics of resistance to phosphonoacetic acid in strain KOS of herpes simplex virus type 1.

Authors:  J T Jofre; P A Schaffer; D S Parris
Journal:  J Virol       Date:  1977-09       Impact factor: 5.103

9.  Herpes simplex virus resistance and sensitivity to phosphonoacetic acid.

Authors:  R W Honess; D H Watson
Journal:  J Virol       Date:  1977-02       Impact factor: 5.103

10.  Rational design of arabinosyl nucleosides as antitumor and antiviral agents.

Authors:  W E Müller
Journal:  Jpn J Antibiot       Date:  1977-12
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  16 in total

Review 1.  Recent advances in cloning herpesviral genomes as infectious bacterial artificial chromosomes.

Authors:  Fuchun Zhou; Shou-Jiang Gao
Journal:  Cell Cycle       Date:  2011-02-01       Impact factor: 4.534

2.  Sensitivity of arabinosyladenine-resistant mutants of herpes simplex virus to other antiviral drugs and mapping of drug hypersensitivity mutations to the DNA polymerase locus.

Authors:  D M Coen; H E Fleming; L K Leslie; M J Retondo
Journal:  J Virol       Date:  1985-02       Impact factor: 5.103

3.  Selective inhibition of herpesvirus deoxyribonucleic acid synthesis by acycloguanosine, 2'-fluoro-5-iodo-aracytosine, and (E)-5-(2-bromovinyl)-2'-deoxyuridine.

Authors:  A Larsson; B Oberg
Journal:  Antimicrob Agents Chemother       Date:  1981-05       Impact factor: 5.191

4.  Susceptibility of phosphonoformic acid-resistant herpes simplex virus variants to arabinosylnucleosides and aphidicolin.

Authors:  K F Bastow; D D Derse; Y C Cheng
Journal:  Antimicrob Agents Chemother       Date:  1983-06       Impact factor: 5.191

5.  Cooperative effects between two acyclovir resistance loci in herpes simplex virus.

Authors:  G Darby; M J Churcher; B A Larder
Journal:  J Virol       Date:  1984-06       Impact factor: 5.103

6.  Synergism among BIOLF-62, phosphonoformate, and other antiherpetic compounds.

Authors:  K O Smith; K S Galloway; K K Ogilvie; U O Cheriyan
Journal:  Antimicrob Agents Chemother       Date:  1982-12       Impact factor: 5.191

7.  Inhibition of herpesvirus multiplication in guinea pig skin by antiviral compounds.

Authors:  S Alenius
Journal:  Arch Virol       Date:  1980       Impact factor: 2.574

8.  A new nucleoside analog, 9-[[2-hydroxy-1-(hydroxymethyl)ethoxyl]methyl]guanine, highly active in vitro against herpes simplex virus types 1 and 2.

Authors:  K O Smith; K S Galloway; W L Kennell; K K Ogilvie; B K Radatus
Journal:  Antimicrob Agents Chemother       Date:  1982-07       Impact factor: 5.191

9.  Mutations in the herpes simplex virus DNA polymerase gene can confer resistance to 9-beta-D-arabinofuranosyladenine.

Authors:  D M Coen; P A Furman; P T Gelep; P A Schaffer
Journal:  J Virol       Date:  1982-03       Impact factor: 5.103

10.  Herpes simplex virus mutants resistant to arabinosyladenine in the presence of deoxycoformycin.

Authors:  H E Fleming; D M Coen
Journal:  Antimicrob Agents Chemother       Date:  1984-09       Impact factor: 5.191
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