Literature DB >> 213015

Therapeutic effect of trisodium phosphonoformate on cutaneous herpesvirus infection in guinea pigs.

S Alenius, Z Dinter, B Oberg.   

Abstract

When applied topically, trisodium phosphonoformate (PFA) displayed activity against established cutaneous herpesvirus infections in guinea pigs similar to that exhibited by the closely related phosphonoacetic acid (PAA); however, unlike PAA, PFA was not locally skin irritating. The therapeutic benefits of topical application of PFA were clearly evident when application was delayed for 48 h after virus inoculation, at which time lesions were well developed. The therapeutic effect was dependent on the concentration of PFA and the duration of treatment. PFA exhibited significant activity against established infections when administered intraperitoneally, although it was less effective via this systemic route than when applied topically.

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Year:  1978        PMID： 213015      PMCID： PMC352473          DOI： 10.1128/AAC.14.3.408

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  9 in total

1.  The activity of iododeoxyuridine, adenine arabinoside, cytosine arabinoside, ribavirin and phosphonoacetic acid against herpes virus in the hairless mouse model.

Authors:  S R Harris; M R Boyd
Journal:  J Antimicrob Chemother       Date:  1977-03       Impact factor: 5.790

2.  Inhibition of herpesvirus replication and herpesvirus-induced deoxyribonucleic acid polymerase by phosphonoformate.

Authors:  J M Reno; L F Lee; J A Boezi
Journal:  Antimicrob Agents Chemother       Date:  1978-02       Impact factor: 5.191

3.  Guinea pig model for cutaneous herpes simplex virus infection.

Authors:  W R Hubler; T D Felber; D Troll; M Jarratt
Journal:  J Invest Dermatol       Date:  1974-02       Impact factor: 8.551

4.  Characterization of herpes simplex virus strains differing in their effects on social behaviour of infected cells.

Authors:  P M Ejercito; E D Kieff; B Roizman
Journal:  J Gen Virol       Date:  1968-05       Impact factor: 3.891

5.  The effect of 5-iodo-2'-deoxyuridine on herpes simplex virus infections in guinea-pig skin.

Authors:  A H Tomlinson; F O Maccallum
Journal:  Br J Exp Pathol       Date:  1968-06

6.  Comparison of activity of herpes virus inhibitors.

Authors:  P Collins; D J Bauer
Journal:  J Antimicrob Chemother       Date:  1977-03       Impact factor: 5.790

7.  Cutaneous herpes simplex virus infection of guinea pigs as a model for antiviral chemotherapy.

Authors:  T W Schafer; M Lieberman; J Everitt; P Came
Journal:  Ann N Y Acad Sci       Date:  1977-03-04       Impact factor: 5.691

8.  The natural history of recurrent herpes simplex labialis: implications for antiviral therapy.

Authors:  S L Spruance; J C Overall; E R Kern; G G Krueger; V Pliam; W Miller
Journal:  N Engl J Med       Date:  1977-07-14       Impact factor: 91.245

9.  Immune response and latent infection after topical treatment of herpes simplex virus infection in hairless mice.

Authors:  R J Klein; A E Friedman-Kien; A A Fondak; E Buimovici-Klein
Journal:  Infect Immun       Date:  1977-06       Impact factor: 3.441
  9 in total
  10 in total

1.  Topical treatment of cutaneous herpes simplex virus infection in hairless mice with (E)-5-(2-bromovinyl)-2'-deoxyuridine and related compounds.

Authors:  E de Clercq
Journal:  Antimicrob Agents Chemother       Date:  1984-08       Impact factor: 5.191

2.  Latent infections of sensory ganglia as influenced by phosphonoformate treatment of herpes simplex virus-induced skin infections in hairless mice.

Authors:  R J Klein; E DeStefano; E Brady; A E Friedman-Kien
Journal:  Antimicrob Agents Chemother       Date:  1979-09       Impact factor: 5.191

3.  Inhibition of African swine fever virus in cultured swine monocytes by phosphonoacetic acid (PAA) and by phosphonoformic acid (PFA).

Authors:  F Villinger; E V Genovesi; D J Gerstner; T C Whyard; R C Knudsen
Journal:  Arch Virol       Date:  1990       Impact factor: 2.574

4.  Reversible effects on cellular metabolism and proliferation by trisodium phosphonoformate.

Authors:  K Stenberg; A Larsson
Journal:  Antimicrob Agents Chemother       Date:  1978-11       Impact factor: 5.191

5.  Inhibition of herpesvirus multiplication in guinea pig skin by antiviral compounds.

Authors:  S Alenius
Journal:  Arch Virol       Date:  1980       Impact factor: 2.574

6.  Relative potencies of different anti-herpes agents in the topical treatment of cutaneous herpes simplex virus infection of athymic nude mice.

Authors:  J Descamps; E De Clercq; P J Barr; A S Jones; R T Walker; P F Torrence; D Shugar
Journal:  Antimicrob Agents Chemother       Date:  1979-11       Impact factor: 5.191

7.  Persistent reactivable latent herpes simplex virus infection in trigeminal ganglia of mice treated with antiviral drugs.

Authors:  B Svennerholm; A Vahlne; E Lycke
Journal:  Arch Virol       Date:  1981       Impact factor: 2.574

8.  Characteristics of herpesvirus mutants resistant to phosphonoformate and phosphonoacetate.

Authors:  B Eriksson; B Oberg
Journal:  Antimicrob Agents Chemother       Date:  1979-06       Impact factor: 5.191

9.  Effect of trisodium phosphonoformate in genital infection of female guinea pigs with herpes simplex virus type 2.

Authors:  S Alenius; H Nordlinder
Journal:  Arch Virol       Date:  1979       Impact factor: 2.574

10.  Advanced tracing tools: functional neuronal expression of virally encoded fluorescent calcium indicator proteins.

Authors:  Markus Rothermel; Daniela Brunert; Barbara G Klupp; Matthias Luebbert; Thomas C Mettenleiter; Hanns Hatt
Journal:  J Neurovirol       Date:  2009-09       Impact factor: 2.643
  10 in total

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