Literature DB >> 197275

Genetics of resistance to phosphonoacetic acid in strain KOS of herpes simplex virus type 1.

J T Jofre, P A Schaffer, D S Parris.   

Abstract

A DNA- temperature-sensitive mutant of herpes simplex virus type 1 exhibiting thermolabile DNA polymerase activity, tsD9, was shown to be resistant to phosphonoacetic acid (PAA) when plated at the permissive temperature. ts+ revertants of tsD9 were PAA sensitive and exhibited DNA polymerase activity intermediate between that of the wild-type virus and tsD9, indicating that both temperature sensitivity and sensitivity to PAA are controlled by the same gene. Since the position of tsD9 on the existing herpes simplex virus type 1 linkage map is known, the locus for PAA resistance--and therefore for the structural gene for viral DNA polymerase--has been identified.

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Year:  1977        PMID： 197275      PMCID： PMC515897     

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  10 in total

1.  Inhibition of herpes simplex virus replication by phosphonoacetic acid.

Authors:  L R Overby; E E Robishaw; J B Schleicher; A Rueter; N L Shipkowitz; J C Mao
Journal:  Antimicrob Agents Chemother       Date:  1974-09       Impact factor: 5.191

2.  DNA synthesis and DNA polymerase activity of herpes simplex virus type 1 temperature-sensitive mutants.

Authors:  G M Aron; D J Purifoy; P A Schaffer
Journal:  J Virol       Date:  1975-09       Impact factor: 5.103

3.  DNA polymerase induction by DNA-negative temperature-sensitive mutants of herpes simplex virus type 2.

Authors:  D J Purifoy; M Benyesh-Melnick
Journal:  Virology       Date:  1975-12       Impact factor: 3.616

4.  Isolation of herpes simplex virus clones and drug resistant mutants in microcultures.

Authors:  R J Klein
Journal:  Arch Virol       Date:  1975       Impact factor: 2.574

5.  Recombination between temperature-sensitive mutants of herpes simplex virus type 1.

Authors:  P A Schaffer; M J Tevethia; M Benyesh-Melnick
Journal:  Virology       Date:  1974-03       Impact factor: 3.616

6.  Temperature-sensitive mutants of herpes simplex virus type 1: isolation, complementation and partial characterization.

Authors:  P A Schaffer; G M Aron; N Biswal; M Benyesh-Melnick
Journal:  Virology       Date:  1973-03       Impact factor: 3.616

7.  Inhibition of DNA polymerase from herpes simplex virus-infected wi-38 cells by phosphonoacetic Acid.

Authors:  J C Mao; E E Robishaw; L R Overby
Journal:  J Virol       Date:  1975-05       Impact factor: 5.103

8.  Herpesvirus proteins: DNA polymerase and pyrimidine deoxynucleoside kinase activities in temperature-sensitive mutants of herpes simplex virus type 2.

Authors:  J Hay; H Moss; A T Jamieson; M C Timbury
Journal:  J Gen Virol       Date:  1976-04       Impact factor: 3.891

9.  Mutants of herpes simplex virus types 1 and 2 that are resistant to phosphonoacetic acid induce altered DNA polymerase activities in infected cells.

Authors:  J Hay; J H Subak-Sharpe
Journal:  J Gen Virol       Date:  1976-04       Impact factor: 3.891

10.  Suppression of herpes simplex virus infection by phosphonoacetic acid.

Authors:  N L Shipkowitz; R R Bower; R N Appell; C W Nordeen; L R Overby; W R Roderick; J B Schleicher; A M Von Esch
Journal:  Appl Microbiol       Date:  1973-09
  10 in total
  46 in total

1.  Use of a single monoclonal antibody to determine the susceptibilities of herpes simplex virus type 1 and type 2 clinical isolates to acyclovir.

Authors:  Christine Chutkowski; Betty Olson; Ann McDonough; James Mahoney; James J McSharry
Journal:  Clin Diagn Lab Immunol       Date:  2002-11

2.  Evidence against a simple tethering model for enhancement of herpes simplex virus DNA polymerase processivity by accessory protein UL42.

Authors:  Murari Chaudhuri; Deborah S Parris
Journal:  J Virol       Date:  2002-10       Impact factor: 5.103

3.  Priscilla Schaffer (1941-2009): a stalwart herpesvirologist.

Authors:  Donald Coen
Journal:  J Virol       Date:  2010-04-28       Impact factor: 5.103

4.  Recombination and linkage between structural and regulatory genes of herpes simplex virus type 1: study of the functional organization of the genome.

Authors:  R W Honess; A Buchan; I W Halliburton; D H Watson
Journal:  J Virol       Date:  1980-06       Impact factor: 5.103

5.  Localization of the herpes simplex virus type 1 65-kilodalton DNA-binding protein and DNA polymerase in the presence and absence of viral DNA synthesis.

Authors:  L D Goodrich; P A Schaffer; D I Dorsky; C S Crumpacker; D S Parris
Journal:  J Virol       Date:  1990-12       Impact factor: 5.103

6.  Aanlysis of dCMP deaminase and CDP reductase levels in hamster cells infected by herpes simplex virus.

Authors:  Y Langelier; M Déchamps; G Buttin
Journal:  J Virol       Date:  1978-06       Impact factor: 5.103

7.  High-frequency transfer of cloned herpes simplex virus type 1 sequences to mammalian cells by protoplast fusion.

Authors:  R M Sandri-Goldin; A L Goldin; M Levine; J C Glorioso
Journal:  Mol Cell Biol       Date:  1981-08       Impact factor: 4.272

8.  Isolation of a herpes simplex virus type 1 mutant deleted for the essential UL42 gene and characterization of its null phenotype.

Authors:  P A Johnson; M G Best; T Friedmann; D S Parris
Journal:  J Virol       Date:  1991-02       Impact factor: 5.103

9.  Requirement for cellular cyclin-dependent kinases in herpes simplex virus replication and transcription.

Authors:  L M Schang; J Phillips; P A Schaffer
Journal:  J Virol       Date:  1998-07       Impact factor: 5.103

10.  Resistance of herpes simplex virus to 9-[[2-hydroxy-1-(hydroxymethyl)ethoxy]methyl]guanine: physical mapping of drug synergism within the viral DNA polymerase locus.

Authors:  C S Crumpacker; P N Kowalsky; S A Oliver; L E Schnipper; A K Field
Journal:  Proc Natl Acad Sci U S A       Date:  1984-03       Impact factor: 11.205
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