Literature DB >> 6095755

Herpes simplex virus mutants resistant to arabinosyladenine in the presence of deoxycoformycin.

H E Fleming, D M Coen.   

Abstract

Herpes simplex virus mutants PAAr5, AraAr6, AraAr7, AraAr9, and AraAr13, which previously had been shown to be resistant to arabinosyladenine (araA) alone, were found to be resistant to araA in the presence of high concentrations of the adenosine deaminase inhibitor, deoxycoformycin. The marker conferring resistance to araA and deoxycoformycin in mutant PAAr5 was mapped finely to an 0.8-kilobase-pair region in the herpes simplex virus DNA polymerase locus. These results indicate that the mutants are resistant to araA itself rather than to its deamination product and confirm the importance of the viral polymerase in the antiviral action of araA.

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Year:  1984        PMID： 6095755      PMCID： PMC176175          DOI： 10.1128/AAC.26.3.382

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  32 in total

1.  Mammalian adenylosuccinate synthetase. Nucleotide monophosphate substrates and inhibitors.

Authors:  T Spector; R L Miller
Journal:  Biochim Biophys Acta       Date:  1976-09-14

2.  Spectrum of human cytomegalovirus complement-fixing antigens.

Authors:  G R Dreesman; M Benyesh-Melnick
Journal:  J Immunol       Date:  1967-12       Impact factor: 5.422

3.  Mammalian adenylosuccinate lyase. Participation in the conversion of 2'-dIMP and beta-D-arabinosyl-IMP to adenine nucleotides.

Authors:  T Spector
Journal:  Biochim Biophys Acta       Date:  1977-04-12

4.  Tight-binding inhibitors--IV. Inhibition of adenosine deaminases by various inhibitors.

Authors:  R P Agarwal; T Spector; R E Parks
Journal:  Biochem Pharmacol       Date:  1977-03-01       Impact factor: 5.858

5.  Mutants of herpes simplex virus types 1 and 2 that are resistant to phosphonoacetic acid induce altered DNA polymerase activities in infected cells.

Authors:  J Hay; J H Subak-Sharpe
Journal:  J Gen Virol       Date:  1976-04       Impact factor: 3.891

6.  Antiviral activity of arabinosyladenine and arabinosylhypoxanthine in herpes simplex virus-infected KB cells: selective inhibition of viral deoxyribonucleic acid synthesis in synchronized suspension cultures.

Authors:  C Shipman; S H Smith; R H Carlson; J C Drach
Journal:  Antimicrob Agents Chemother       Date:  1976-01       Impact factor: 5.191

7.  Genetics of resistance to phosphonoacetic acid in strain KOS of herpes simplex virus type 1.

Authors:  J T Jofre; P A Schaffer; D S Parris
Journal:  J Virol       Date:  1977-09       Impact factor: 5.103

8.  Inhibition of mammalian DNA polymerase by the 5'-triphosphate of 1-beta-d-arabinofuranosylcytosine and the 5'-triphosphate of 9-beta-d-arabinofuranoxyladenine.

Authors:  J J Furth; S S Cohen
Journal:  Cancer Res       Date:  1968-10       Impact factor: 12.701

9.  Antiviral activity of arabinosyladenine and arabinosylhypoxanthine in herpes simplex virus-infected KB cells: selective inhibition of viral deoxyribonucleic acid synthesis in the presence of an adenosine deaminase inhibitor.

Authors:  P M Schwartz; C Shipman; J C Drach
Journal:  Antimicrob Agents Chemother       Date:  1976-07       Impact factor: 5.191

10.  Herpes simplex virus resistance and sensitivity to phosphonoacetic acid.

Authors:  R W Honess; D H Watson
Journal:  J Virol       Date:  1977-02       Impact factor: 5.103
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  4 in total

1.  Sensitivity of arabinosyladenine-resistant mutants of herpes simplex virus to other antiviral drugs and mapping of drug hypersensitivity mutations to the DNA polymerase locus.

Authors:  D M Coen; H E Fleming; L K Leslie; M J Retondo
Journal:  J Virol       Date:  1985-02       Impact factor: 5.103

2.  Pathogenicity of herpes simplex virus mutants containing drug resistance mutations in the viral DNA polymerase gene.

Authors:  H J Field; D M Coen
Journal:  J Virol       Date:  1986-10       Impact factor: 5.103

3.  Mutation within the herpes simplex virus DNA polymerase gene conferring resistance to (R)-9-(3,4-dihydroxybutyl)guanine.

Authors:  H C Chiou; K M Kerns; D M Coen
Journal:  Antimicrob Agents Chemother       Date:  1986-09       Impact factor: 5.191

4.  Development and evaluation of a host-targeted antiviral that abrogates herpes simplex virus replication through modulation of arginine-associated metabolic pathways.

Authors:  Maria Dulfary Sanchez; Augusto C Ochoa; Timothy P Foster
Journal:  Antiviral Res       Date:  2016-05-15       Impact factor: 5.970
  4 in total

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