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Literature DB >> 206200

Inhibition of herpesvirus replication and herpesvirus-induced deoxyribonucleic acid polymerase by phosphonoformate.

Abstract

Phosphonoformate was found to be an inhibitor of the deoxyribonucleic acid polymerase induced by the herpesvirus of turkeys. The apparent inhibition constants were 1 to 3 muM. Phosphonoformate was also able to block the replication in cell culture of Marek's disease herpesvirus, the herpesvirus of turkeys, and herpes simplex virus. It was as effective as phosphonoacetate. Phosphonoformate was not an effective inhibitor of a phosphonoacetate-resistant mutant of the herpesvirus of turkeys nor of its induced deoxyribonucleic acid polymerase.

Entities: Chemical Species

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Year: 1978 PMID： 206200 PMCID： PMC352212 DOI： 10.1128/AAC.13.2.188

Source DB: PubMed Journal: Antimicrob Agents Chemother ISSN： 0066-4804 Impact factor: 5.191

21 in total

1. Inhibition of Epstein-Barr virus DNA synthesis and late gene expression by phosphonoacetic acid.

Authors: W C Summers; G Klein
Journal: J Virol Date: 1976-04 Impact factor: 5.103

2. Effect of phosphonoacetate on Marek's disease virus replication.

Authors: L F Lee; K Nazerian; S S Leinbach; J M Reno; J A Boezi
Journal: J Natl Cancer Inst Date: 1976-04 Impact factor: 13.506

3. Genital Herpesvirus homonis infection in mice. II. Treatment with phosphonoacetic acid, adenine arabinoside, and adenine arabinoside 5'-monophosphate.

Authors: E R Kern; J T Richards; J C Overall; L A Glasgow
Journal: J Infect Dis Date: 1977-04 Impact factor: 5.226

4. Phosphonoacetic acid in the treatment of experimental herpes simplex keratitis.

Authors: D D Gerstein; C R Dawson; J O O
Journal: Antimicrob Agents Chemother Date: 1975-03 Impact factor: 5.191

5. Experimental encephalitis caused by herpes simplex virus: comparison of treatment with tilorone hydrochloride and phosphonoacetic acid.

Authors: J F Fitzwilliam; J F Griffith
Journal: J Infect Dis Date: 1976-06 Impact factor: 5.226

6. Mutants of herpes simplex virus types 1 and 2 that are resistant to phosphonoacetic acid induce altered DNA polymerase activities in infected cells.

Authors: J Hay; J H Subak-Sharpe
Journal: J Gen Virol Date: 1976-04 Impact factor: 3.891

7. Human cytomegalovirus. IV. Specific inhibition of virus-induced DNA polymerase activity and viral DNA replication by phosphonoacetic acid.

Authors: E S Huang
Journal: J Virol Date: 1975-12 Impact factor: 5.103

8. Mode of inhibition of herpes simplex virus DNA polymerase by phosphonoacetate.

Authors: J C Mao; E E Robishaw
Journal: Biochemistry Date: 1975-12-16 Impact factor: 3.162

9. Immunofluorescence in the study of Marek's disease. I. Detection of antigen in cell culture and an antigenic comparison of eight isolates.

Authors: H G Purchase
Journal: J Virol Date: 1969-06 Impact factor: 5.103

10. Synthesis and anti-herpes simplex activity of analogues of phosphonoacetic acid.

Authors: T R Herrin; J S Fairgrieve; R R Bower; N L Shipkowitz
Journal: J Med Chem Date: 1977-05 Impact factor: 7.446

27 in total

1. Engineered herpes simplex virus DNA polymerase point mutants: the most highly conserved region shared among alpha-like DNA polymerases is involved in substrate recognition.

Authors: A I Marcy; C B Hwang; K L Ruffner; D M Coen
Journal: J Virol Date: 1990-12 Impact factor: 5.103

Inhibition of herpesvirus replication and herpesvirus-induced deoxyribonucleic acid polymerase by phosphonoformate.

1. Inhibition of Epstein-Barr virus DNA synthesis and late gene expression by phosphonoacetic acid.

2. Effect of phosphonoacetate on Marek's disease virus replication.

3. Genital Herpesvirus homonis infection in mice. II. Treatment with phosphonoacetic acid, adenine arabinoside, and adenine arabinoside 5'-monophosphate.

4. Phosphonoacetic acid in the treatment of experimental herpes simplex keratitis.

5. Experimental encephalitis caused by herpes simplex virus: comparison of treatment with tilorone hydrochloride and phosphonoacetic acid.

6. Mutants of herpes simplex virus types 1 and 2 that are resistant to phosphonoacetic acid induce altered DNA polymerase activities in infected cells.

7. Human cytomegalovirus. IV. Specific inhibition of virus-induced DNA polymerase activity and viral DNA replication by phosphonoacetic acid.

8. Mode of inhibition of herpes simplex virus DNA polymerase by phosphonoacetate.

9. Immunofluorescence in the study of Marek's disease. I. Detection of antigen in cell culture and an antigenic comparison of eight isolates.

10. Synthesis and anti-herpes simplex activity of analogues of phosphonoacetic acid.

1. Engineered herpes simplex virus DNA polymerase point mutants: the most highly conserved region shared among alpha-like DNA polymerases is involved in substrate recognition.

2. Identification of amino acids in herpes simplex virus DNA polymerase involved in substrate and drug recognition.

3. Therapeutic effect of trisodium phosphonoformate on cutaneous herpesvirus infection in guinea pigs.

4. Treatment of experimental herpesvirus infections with phosphonoformate and some comparisons with phosphonoacetate.

5. Concentration-dependent effects of foscarnet on the cell cycle.

6. Phosphonoacyl compounds as inhibitors of viral nucleic acid polymerases.

7. Reversible effects on cellular metabolism and proliferation by trisodium phosphonoformate.

8. Synergism among BIOLF-62, phosphonoformate, and other antiherpetic compounds.

9. Comparison of properties of woodchuck hepatitis virus and human hepatitis B virus endogenous DNA polymerases.

10. Comparative studies of interferon and three antiviral agents on neurotropic and oncogenic herpesviruses.