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Literature DB >> 6311091

Susceptibility of phosphonoformic acid-resistant herpes simplex virus variants to arabinosylnucleosides and aphidicolin.

Abstract

A plaque-reduction assay was used to examine the susceptibility of five phosphonoformic acid-resistant variants of herpes simplex virus type 1 to arabinosylnucleosides and aphidicolin. These viruses were cross-resistant to arabinosylhypoxanthine and to arabinosyladenine when tested in the absence of deoxycoformycin, a deaminase inhibitor. In the presence of deoxycoformycin, no cross-resistance between arabinosyladenine and phosphonoformic acid was observed. The two variants tested were cross-resistant to arabinosylthymine, and all five variants were collaterally susceptible to aphidicolin inhibition.

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Year: 1983 PMID： 6311091 PMCID： PMC185003 DOI： 10.1128/AAC.23.6.914

Source DB: PubMed Journal: Antimicrob Agents Chemother ISSN： 0066-4804 Impact factor: 5.191

20 in total

1. Isolation of herpes simplex virus clones and drug resistant mutants in microcultures.

Authors: R J Klein
Journal: Arch Virol Date: 1975 Impact factor: 2.574

2. Deoxyribonucleotide metabolism in Herpes simplex virus infected HeLa cells.

Authors: Y C Cheng; B Goz; W H Prusoff
Journal: Biochim Biophys Acta Date: 1975-05-16

3. Antiviral activity of arabinosyladenine and arabinosylhypoxanthine in herpes simplex virus-infected KB cells: selective inhibition of viral deoxyribonucleic acid synthesis in synchronized suspension cultures.

Authors: C Shipman; S H Smith; R H Carlson; J C Drach
Journal: Antimicrob Agents Chemother Date: 1976-01 Impact factor: 5.191

4. Antiviral activity of arabinosylthymine in herpesviral replication: mechanism of action in vivo and in vitro.

Authors: J F Aswell; G P Allen; A T Jamieson; D E Campbell; G A Gentry
Journal: Antimicrob Agents Chemother Date: 1977-08 Impact factor: 5.191

5. Antiviral effects of aphidicolin, a new antibiotic produced by Cephalosporium aphidicola.

Authors: R A Bucknall; H Moores; R Simms; B Hesp
Journal: Antimicrob Agents Chemother Date: 1973-09 Impact factor: 5.191

6. Two distinct loci confer resistance to acycloguanosine in herpes simplex virus type 1.

Authors: D M Coen; P A Schaffer
Journal: Proc Natl Acad Sci U S A Date: 1980-04 Impact factor: 11.205

Review 7. Aranucleosides and aranucleotides in viral chemotherapy.

Authors: T W North; S S Cohen
Journal: Pharmacol Ther Date: 1979 Impact factor: 12.310

8. Antiviral activity of arabinosyladenine and arabinosylhypoxanthine in herpes simplex virus-infected KB cells: selective inhibition of viral deoxyribonucleic acid synthesis in the presence of an adenosine deaminase inhibitor.

Authors: P M Schwartz; C Shipman; J C Drach
Journal: Antimicrob Agents Chemother Date: 1976-07 Impact factor: 5.191

9. Herpes simplex virus resistance and sensitivity to phosphonoacetic acid.

Authors: R W Honess; D H Watson
Journal: J Virol Date: 1977-02 Impact factor: 5.103

10. Characteristics of herpesvirus mutants resistant to phosphonoformate and phosphonoacetate.

Authors: B Eriksson; B Oberg
Journal: Antimicrob Agents Chemother Date: 1979-06 Impact factor: 5.191

14 in total

1. Identification of amino acids in herpes simplex virus DNA polymerase involved in substrate and drug recognition.

Authors: J S Gibbs; H C Chiou; K F Bastow; Y C Cheng; D M Coen
Journal: Proc Natl Acad Sci U S A Date: 1988-09 Impact factor: 11.205

2. Sensitivity of arabinosyladenine-resistant mutants of herpes simplex virus to other antiviral drugs and mapping of drug hypersensitivity mutations to the DNA polymerase locus.

Authors: D M Coen; H E Fleming; L K Leslie; M J Retondo
Journal: J Virol Date: 1985-02 Impact factor: 5.103

3. Susceptibility to other antiherpes drugs of pathogenic variants of herpes simplex virus selected for resistance to acyclovir.

Authors: B A Larder; G Darby
Journal: Antimicrob Agents Chemother Date: 1986-05 Impact factor: 5.191

4. Susceptibility of vaccine strains of varicella-zoster virus to antiviral compounds.

Authors: S R Preblud; A M Arbeter; E A Proctor; S E Starr; S A Plotkin
Journal: Antimicrob Agents Chemother Date: 1984-04 Impact factor: 5.191

5. Mutually exclusive inhibition of herpesvirus DNA polymerase by aphidicolin, phosphonoformate, and acyclic nucleoside triphosphates.

Authors: K B Frank; Y C Cheng
Journal: Antimicrob Agents Chemother Date: 1985-04 Impact factor: 5.191

Review 6. Antiviral therapy in human immunodeficiency virus infections. Current status (Part II).

Authors: E Sandström; B Oberg
Journal: Drugs Date: 1993-05 Impact factor: 9.546

7. Genetic characterization of the vaccinia virus DNA polymerase: cytosine arabinoside resistance requires a variable lesion conferring phosphonoacetate resistance in conjunction with an invariant mutation localized to the 3'-5' exonuclease domain.

Authors: J A Taddie; P Traktman
Journal: J Virol Date: 1993-07 Impact factor: 5.103

8. Genetic characterization of the vaccinia virus DNA polymerase: identification of point mutations conferring altered drug sensitivities and reduced fidelity.

Authors: J A Taddie; P Traktman
Journal: J Virol Date: 1991-02 Impact factor: 5.103

9. Antiherpesvirus activity and mechanism of action of indolo-(2,3-b)quinoxaline and analogs.

Authors: J Harmenberg; B Wahren; J Bergman; S Akerfeldt; L Lundblad
Journal: Antimicrob Agents Chemother Date: 1988-11 Impact factor: 5.191

10. Sequence and mapping analyses of the herpes simplex virus DNA polymerase gene predict a C-terminal substrate binding domain.

Authors: J S Gibbs; H C Chiou; J D Hall; D W Mount; M J Retondo; S K Weller; D M Coen
Journal: Proc Natl Acad Sci U S A Date: 1985-12 Impact factor: 11.205