Literature DB >> 210500

Trisodium phosphonoformate, a new antiviral compound.

E Helgstrand, B Eriksson, N G Johansson, B Lannerö, A Larsson, A Misiorny, J O Norén, B Sjöberg, K Stenberg, G Stening, S Stridh, B Oberg.   

Abstract

Trisodium phosphonoformate selectively inhibits cell-free DNA polymerase activity induced by herpesvirus. The new inhibitor has an antiviral effect on herpes simplex virus types 1 and 2, pseudorables virus, and infectious bovine rhinotracheitis virus in cell culture. It has a good therapeutic activity against cutaneous herpes simplex virus infection in guinea pigs.

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Year:  1978        PMID： 210500     DOI： 10.1126/science.210500

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  54 in total

Review 1.  Antiviral therapy in AIDS. Clinical pharmacological properties and therapeutic experience to date.

Authors:  E G Sandström; J C Kaplan
Journal:  Drugs       Date:  1987-09       Impact factor: 9.546

2.  Multicomponent origin of cytomegalovirus lytic-phase DNA replication.

Authors:  D G Anders; S M Punturieri
Journal:  J Virol       Date:  1991-02       Impact factor: 5.103

Review 3.  Antiviral therapy: current concepts and practices.

Authors:  B Bean
Journal:  Clin Microbiol Rev       Date:  1992-04       Impact factor: 26.132

4.  Synergistic inhibition of human immunodeficiency virus isolates (including 3'-azido-3'-deoxythymidine-resistant isolates) by foscarnet in combination with 2',3'-dideoxyinosine or 2',3'-dideoxycytidine.

Authors:  S Palmer; J Harmenberg; S Cox
Journal:  Antimicrob Agents Chemother       Date:  1996-05       Impact factor: 5.191

5.  Posttranscriptional regulation of a class of human cytomegalovirus phosphoproteins encoded by an early transcription unit.

Authors:  D A Wright; D H Spector
Journal:  J Virol       Date:  1989-07       Impact factor: 5.103

6.  Sensitivity of arabinosyladenine-resistant mutants of herpes simplex virus to other antiviral drugs and mapping of drug hypersensitivity mutations to the DNA polymerase locus.

Authors:  D M Coen; H E Fleming; L K Leslie; M J Retondo
Journal:  J Virol       Date:  1985-02       Impact factor: 5.103

7.  Reversible effects on cellular metabolism and proliferation by trisodium phosphonoformate.

Authors:  K Stenberg; A Larsson
Journal:  Antimicrob Agents Chemother       Date:  1978-11       Impact factor: 5.191

8.  DNA and RNA virus species are inhibited by xanthates, a class of antiviral compounds with unique properties.

Authors:  G Sauer; E Amtmann; K Melber; A Knapp; K Müller; K Hummel; A Scherm
Journal:  Proc Natl Acad Sci U S A       Date:  1984-06       Impact factor: 11.205

9.  D,L-alpha-difluoromethylornithine inhibits human cytomegalovirus replication.

Authors:  W Gibson; R van Breemen; A Fields; R LaFemina; A Irmiere
Journal:  J Virol       Date:  1984-04       Impact factor: 5.103

Review 10.  Antiherpes drugs: promises and pitfalls.

Authors:  E de Clercq
Journal:  Eur J Clin Microbiol       Date:  1984-04       Impact factor: 3.267
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