Jun Zhang1, Michelle I Knopp1, Michael V Knopp2. 1. Wright Center of Innovation in Biomedical Imaging, Department of Radiology, The Ohio State University Wexner Medical Center, 395 W. 12th Avenue, Room 430, Columbus, OH, 43210, USA. 2. Wright Center of Innovation in Biomedical Imaging, Department of Radiology, The Ohio State University Wexner Medical Center, 395 W. 12th Avenue, Room 430, Columbus, OH, 43210, USA. knopp.16@osu.edu.
Abstract
PURPOSE: To investigate the minimum number of SiPM detectors required for solid-state digital photon counting (DPC) oncologic whole-body 2-deoxy-2-[18F]fluoro-D-glucose ([18F]FDG) positron emission tomography (PET)/X-ray computed tomography (CT). PROCEDURES: A DPC PET/CT (Vereos, Philips) with 23,040 1-to-1 crystal-to-detector couplings was utilized. [18F]FDG PET/CT of a uniformity phantom and 10 oncology patients selected by block randomization from a large clinical trial were included (457 ± 38 MBq, 64 ± 22 min p.i, body mass index (BMI) of 14-41). Sparse-ring PET configurations with 50 % detector reduction in tangential and axial directions were analyzed and compared to the current full ring configuration. Resulting images were reviewed blindly and quantitatively over detectable lesions and the liver. RESULTS: One hundred twelve lesions (d = 10 to 95 mm) were analyzed in the patient population. All lesions remained visible and were demonstrated without compromised image quality under all BMIs in the 50 % sparse detector configurations despite the DPC PET system sensitivity reduction to 1/4th. An excellent consistency of SUVmax measurements of lesions with an average of 5 % SUVmax difference was found between dPET of full and sparse configurations. CONCLUSIONS: The feasibility of either expanding the axial field of view (FOV) by a factor of two or halving the number of detectors was demonstrated for solid-state digital photon counting PET, thus either potentially enabling cost reduction or extended effective axial FOV without increased cost.
PURPOSE: To investigate the minimum number of SiPM detectors required for solid-state digital photon counting (DPC) oncologic whole-body 2-deoxy-2-[18F]fluoro-D-glucose ([18F]FDG) positron emission tomography (PET)/X-ray computed tomography (CT). PROCEDURES: A DPC PET/CT (Vereos, Philips) with 23,040 1-to-1 crystal-to-detector couplings was utilized. [18F]FDG PET/CT of a uniformity phantom and 10 oncology patients selected by block randomization from a large clinical trial were included (457 ± 38 MBq, 64 ± 22 min p.i, body mass index (BMI) of 14-41). Sparse-ring PET configurations with 50 % detector reduction in tangential and axial directions were analyzed and compared to the current full ring configuration. Resulting images were reviewed blindly and quantitatively over detectable lesions and the liver. RESULTS: One hundred twelve lesions (d = 10 to 95 mm) were analyzed in the patient population. All lesions remained visible and were demonstrated without compromised image quality under all BMIs in the 50 % sparse detector configurations despite the DPC PET system sensitivity reduction to 1/4th. An excellent consistency of SUVmax measurements of lesions with an average of 5 % SUVmax difference was found between dPET of full and sparse configurations. CONCLUSIONS: The feasibility of either expanding the axial field of view (FOV) by a factor of two or halving the number of detectors was demonstrated for solid-state digital photon counting PET, thus either potentially enabling cost reduction or extended effective axial FOV without increased cost.
Entities:
Keywords:
2-deoxy-2-[18F]fluoro-D-glucose; Digital photon counting; Silicon photomultiplier; Solid state; Sparse-ring PET; Whole-body PET
Authors: Dennis R Schaart; Herman T van Dam; Stefan Seifert; Ruud Vinke; Peter Dendooven; Herbert Löhner; Freek J Beekman Journal: Phys Med Biol Date: 2009-05-15 Impact factor: 3.609
Authors: David F C Hsu; Ezgi Ilan; William T Peterson; Jorge Uribe; Mark Lubberink; Craig S Levin Journal: J Nucl Med Date: 2017-04-27 Impact factor: 10.057
Authors: Junguo Bian; Jeffrey H Siewerdsen; Xiao Han; Emil Y Sidky; Jerry L Prince; Charles A Pelizzari; Xiaochuan Pan Journal: Phys Med Biol Date: 2010-10-20 Impact factor: 3.609
Authors: Paul Lecoq; Christian Morel; John O Prior; Dimitris Visvikis; Stefan Gundacker; Etiennette Auffray; Peter Križan; Rosana Martinez Turtos; Dominique Thers; Edoardo Charbon; Joao Varela; Christophe de La Taille; Angelo Rivetti; Dominique Breton; Jean-François Pratte; Johan Nuyts; Suleman Surti; Stefaan Vandenberghe; Paul Marsden; Katia Parodi; Jose Maria Benlloch; Mathieu Benoit Journal: Phys Med Biol Date: 2020-10-22 Impact factor: 3.609
Authors: Varsha Viswanath; Austin R Pantel; Margaret E Daube-Witherspoon; Robert Doot; Mark Muzi; David A Mankoff; Joel S Karp Journal: IEEE Trans Radiat Plasma Med Sci Date: 2020-09-02