Literature DB >> 28516169

Hybrid Pixel-Waveform (HPWF) Enabled CdTe Detectors for Small Animal Gamma-Ray Imaging Applications.

A Groll1, K Kim2, H Bhatia3, J C Zhang3, J H Wang3, Z M Shen3, L Cai3, J Dutta2, Q Li4, L J Meng3.   

Abstract

This paper presents the design and preliminary evaluation of small-pixel CdTe gamma ray detectors equipped with a hybrid pixel-waveform (HPWF) readout system for gamma ray imaging applications with additional discussion on CZT due to its similarity. The HPWF readout system utilizes a pixelated anode readout circuitry which is designed to only provide the pixel address. This readout circuitry works in coincidence with a high-speed digitizer to sample the cathode waveform which provides the energy, timing, and depth-of-interaction (DOI) information. This work focuses on the developed and experimentally evaluated prototype HPWF-CdTe detectors with a custom CMOS pixel-ASIC to readout small anode pixels of 350 μm in size, and a discrete waveform sampling circuitry to digitize the signal waveform induced on the large cathode. The intrinsic timing, energy, and spatial resolution were experimentally evaluated in this paper in conjunction with methods for depth of interaction (DOI) partitioning of the CdTe crystal. While the experimental studies discussed in this paper are primarily for evaluating HPWF detectors for small animal PET imaging, these detectors could find their applications for ultrahigh-resolution SPECT and other imaging modalities.

Entities:  

Year:  2016        PMID: 28516169      PMCID: PMC5431752          DOI: 10.1109/TNS.2016.2623807

Source DB:  PubMed          Journal:  IEEE Trans Radiat Plasma Med Sci        ISSN: 2469-7303


  22 in total

1.  MRC-SPECT: A sub-500 μm resolution MR-compatible SPECT system for simultaneous dual-modality study of small animals.

Authors:  Liang Cai; Xiaochun Lai; Zengming Shen; Chin-Tu Chen; Ling-Jian Meng
Journal:  Nucl Instrum Methods Phys Res A       Date:  2014-01-11       Impact factor: 1.455

2.  Evaluating performance of a pixel array semiconductor SPECT system for small animal imaging.

Authors:  Naoki Kubo; Songji Zhao; Yutaka Fujiki; Akiyoshi Kinda; Nobutoku Motomura; Chietsugu Katoh; Tohru Shiga; Hidekazu Kawashima; Yuji Kuge; Nagara Tamaki
Journal:  Ann Nucl Med       Date:  2005-10       Impact factor: 2.668

3.  Spectroscopic Performance of Thick HgI2 Detectors.

Authors:  L J Meng; Z He; B Alexander; J Sandoval
Journal:  IEEE Trans Nucl Sci       Date:  2006-06-26       Impact factor: 1.679

4.  Estimate interaction timing in a large volume HgI2 detector using cathode pulse waveforms.

Authors:  L J Meng; Z He
Journal:  Nucl Instrum Methods Phys Res A       Date:  2005-03-23       Impact factor: 1.455

5.  Study of a high-resolution, 3D positioning cadmium zinc telluride detector for PET.

Authors:  Y Gu; J L Matteson; R T Skelton; A C Deal; E A Stephan; F Duttweiler; T M Gasaway; C S Levin
Journal:  Phys Med Biol       Date:  2011-02-18       Impact factor: 3.609

6.  Energy and coincidence time resolution measurements of CdTe detectors for PET.

Authors:  G Ariño; M Chmeissani; G De Lorenzo; C Puigdengoles; E Cabruja; Y Calderón; M Kolstein; J G Macias-Montero; R Martinez; E Mikhaylova; D Uzun
Journal:  J Instrum       Date:  2013-02       Impact factor: 1.415

7.  Advances in coincidence time resolution for PET.

Authors:  Joshua W Cates; Craig S Levin
Journal:  Phys Med Biol       Date:  2016-02-25       Impact factor: 3.609

8.  In vivo PET imaging of beta-amyloid deposition in mouse models of Alzheimer's disease with a high specific activity PET imaging agent [(18)F]flutemetamol.

Authors:  Anniina Snellman; Johanna Rokka; Francisco R López-Picón; Olli Eskola; Mario Salmona; Gianluigi Forloni; Mika Scheinin; Olof Solin; Juha O Rinne; Merja Haaparanta-Solin
Journal:  EJNMMI Res       Date:  2014-08-01       Impact factor: 3.138

9.  Simulation of the expected performance of a seamless scanner for brain PET based on highly pixelated CdTe detectors.

Authors:  Ekaterina Mikhaylova; Gianluca De Lorenzo; Mokhtar Chmeissani; Machiel Kolstein; Mario Cañadas; Pedro Arce; Yonatan Calderón; Dilber Uzun; Gerard Ariño; José Gabriel Macias-Montero; Ricardo Martinez; Carles Puigdengoles; Enric Cabruja
Journal:  IEEE Trans Med Imaging       Date:  2013-10-04       Impact factor: 10.048

10.  Toward VIP-PIX: A Low Noise Readout ASIC for Pixelated CdTe Gamma-Ray Detectors for Use in the Next Generation of PET Scanners.

Authors:  Jose-Gabriel Macias-Montero; Maher Sarraj; Mokhtar Chmeissani; Carles Puigdengoles; Gianluca De Lorenzo; Ricardo Martínez
Journal:  IEEE Trans Nucl Sci       Date:  2013-08       Impact factor: 1.679

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  7 in total

Review 1.  Innovations in Instrumentation for Positron Emission Tomography.

Authors:  Eric Berg; Simon R Cherry
Journal:  Semin Nucl Med       Date:  2018-03-12       Impact factor: 4.446

2.  Towards time-of-flight PET with a semiconductor detector.

Authors:  Gerard Ariño-Estrada; Gregory S Mitchell; Sun Il Kwon; Junwei Du; Hadong Kim; Leonard J Cirignano; Kanai S Shah; Simon R Cherry
Journal:  Phys Med Biol       Date:  2018-02-16       Impact factor: 3.609

3.  Simulation study of the second-generation MR-compatible SPECT system based on the inverted compound-eye gamma camera design.

Authors:  Xiaochun Lai; Ling-Jian Meng
Journal:  Phys Med Biol       Date:  2018-02-12       Impact factor: 3.609

4.  First Cerenkov charge-induction (CCI) TlBr detector for TOF-PET and proton range verification.

Authors:  Gerard Ariño-Estrada; Gregory S Mitchell; Hadong Kim; Junwei Du; Sun Il Kwon; Leonard J Cirignano; Kanai S Shah; Simon R Cherry
Journal:  Phys Med Biol       Date:  2019-08-28       Impact factor: 3.609

5.  Development of TlBr detectors for PET imaging.

Authors:  Gerard Ariño-Estrada; Junwei Du; Hadong Kim; Leonard J Cirignano; Kanai S Shah; Simon R Cherry; Gregory S Mitchell
Journal:  Phys Med Biol       Date:  2018-07-03       Impact factor: 3.609

6.  A novel depth-of-interaction rebinning strategy for ultrahigh resolution PET.

Authors:  Kyungsang Kim; Joyita Dutta; Andrew Groll; Georges El Fakhri; Ling-Jian Meng; Quanzheng Li
Journal:  Phys Med Biol       Date:  2018-08-14       Impact factor: 3.609

7.  An edge-readout, multilayer detector for positron emission tomography.

Authors:  Xin Li; Maria Ruiz-Gonzalez; Lars R Furenlid
Journal:  Med Phys       Date:  2018-05-06       Impact factor: 4.071

  7 in total

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