BACKGROUND: This study is aimed at comparing the performance of three continuous glucose monitoring (CGM) systems following the Clinical and Laboratory Standards Institute's POCT05-A guideline, which provides recommendations for performance evaluation of CGM systems. METHODS: A total of 12 subjects with type 1 diabetes were enrolled in this study. Each subject wore six CGM systems in parallel, two sensors of each CGM system [FreeStyle Navigator™ (Navigator), MiniMed Guardian® REAL-Time with Enlite sensor (Guardian), DexCom™ Seven® Plus 3rd generation (Seven Plus)]. Each sensor was used for the lifetime specified by the manufacturer. To follow POCT05-A recommendations, glucose excursions were induced on two separate occasions, and venous and capillary blood glucose (BG) concentrations were obtained every 15 min for five consecutive hours. Capillary BG concentrations were measured at least once per hour during the day and once at night. Parameters investigated were CGM-to-BG differences [mean absolute relative difference (MARD)] and sensor-to-sensor differences [precision absolute relative difference (PARD)]. RESULTS: Compared with capillary BG reference readings, the Navigator showed the lowest MARD, with 12.1% overall and 24.6% in the hypoglycemic range; for the Guardian and the Seven Plus, MARD was 16.2%/34.9% and 16.3%/32.7%, respectively. PARD also was lowest for the Navigator (9.6%/9.8%), followed by the Seven Plus (16.7%/25.5%) and the Guardian (18.1%/20.2%). During induced glucose excursions, MARD between CGM and BG was, again, lowest for the Navigator (14.3%), followed by the Seven Plus (15.8%) and the Guardian (19.2%). CONCLUSIONS: In this study, two sensors of each of the three CGM systems were compared in a setting following POCT05-A recommendations. The Navigator CGM system achieved more accurate results than the Guardian or the Seven Plus with respect to MARD and PARD. Performance in the hypoglycemic range was markedly worse for all CGM systems when compared with BG results.
BACKGROUND: This study is aimed at comparing the performance of three continuous glucose monitoring (CGM) systems following the Clinical and Laboratory Standards Institute's POCT05-A guideline, which provides recommendations for performance evaluation of CGM systems. METHODS: A total of 12 subjects with type 1 diabetes were enrolled in this study. Each subject wore six CGM systems in parallel, two sensors of each CGM system [FreeStyle Navigator™ (Navigator), MiniMed Guardian® REAL-Time with Enlite sensor (Guardian), DexCom™ Seven® Plus 3rd generation (Seven Plus)]. Each sensor was used for the lifetime specified by the manufacturer. To follow POCT05-A recommendations, glucose excursions were induced on two separate occasions, and venous and capillary blood glucose (BG) concentrations were obtained every 15 min for five consecutive hours. Capillary BG concentrations were measured at least once per hour during the day and once at night. Parameters investigated were CGM-to-BG differences [mean absolute relative difference (MARD)] and sensor-to-sensor differences [precision absolute relative difference (PARD)]. RESULTS: Compared with capillary BG reference readings, the Navigator showed the lowest MARD, with 12.1% overall and 24.6% in the hypoglycemic range; for the Guardian and the Seven Plus, MARD was 16.2%/34.9% and 16.3%/32.7%, respectively. PARD also was lowest for the Navigator (9.6%/9.8%), followed by the Seven Plus (16.7%/25.5%) and the Guardian (18.1%/20.2%). During induced glucose excursions, MARD between CGM and BG was, again, lowest for the Navigator (14.3%), followed by the Seven Plus (15.8%) and the Guardian (19.2%). CONCLUSIONS: In this study, two sensors of each of the three CGM systems were compared in a setting following POCT05-A recommendations. The Navigator CGM system achieved more accurate results than the Guardian or the Seven Plus with respect to MARD and PARD. Performance in the hypoglycemic range was markedly worse for all CGM systems when compared with BG results.
Authors: Richard L Weinstein; Sherwyn L Schwartz; Ronald L Brazg; Jolyon R Bugler; Thomas A Peyser; Geoffrey V McGarraugh Journal: Diabetes Care Date: 2007-03-02 Impact factor: 19.112
Authors: William L Clarke; Stacey Anderson; Leon Farhy; Marc Breton; Linda Gonder-Frederick; Daniel Cox; Boris Kovatchev Journal: Diabetes Care Date: 2005-10 Impact factor: 19.112
Authors: Darrell M Wilson; Roy W Beck; William V Tamborlane; Mariya J Dontchev; Craig Kollman; Peter Chase; Larry A Fox; Katrina J Ruedy; Eva Tsalikian; Stuart A Weinzimer Journal: Diabetes Care Date: 2007-01 Impact factor: 19.112
Authors: J K Nielsen; G Freckmann; C Kapitza; G Ocvirk; K H Koelker; U Kamecke; R Gillen; I Amann-Zalan; N Jendrike; J S Christiansen; T Koschinsky; L Heinemann Journal: Diabet Med Date: 2009-07 Impact factor: 4.359
Authors: Satish K Garg; James Smith; Christie Beatson; Benita Lopez-Baca; Mary Voelmle; Peter A Gottlieb Journal: Diabetes Technol Ther Date: 2009-02 Impact factor: 6.118
Authors: Harald Kirchsteiger; Lutz Heinemann; Guido Freckmann; Volker Lodwig; Günther Schmelzeisen-Redeker; Michael Schoemaker; Luigi Del Re Journal: J Diabetes Sci Technol Date: 2015-09-01
Authors: Amin Sharifi; Andrea Varsavsky; Johanna Ulloa; Jodie C Horsburgh; Sybil A McAuley; Balasubramanian Krishnamurthy; Alicia J Jenkins; Peter G Colman; Glenn M Ward; Richard J MacIsaac; Rajiv Shah; David N O'Neal Journal: J Diabetes Sci Technol Date: 2016-05-03