Stem modularity alone is not effective in reducing dislocation rate in hip revision surgery.

BACKGROUND: Dislocation is a serious complication following total hip arthroplasty (THA). Femoral revision using monoblock components has been associated with high incidence of subsidence and dislocation. Advantages of modular stems in THA have long been debated. The aim of this retrospective study is to assess the capability of an uncemented modular stem in decreasing the incidence of early dislocation subsequent to revision THA.
MATERIALS AND METHODS: We evaluated the dislocation rate during the first 2 years following revision surgery in two groups of patients who were treated by implantation of a cementless tapered femoral prosthesis; a standard-modularity stem (Wagner SL) and an increased-modularity stem (Profemur R) were used, respectively, in 66 hips (group I, 64 patients) and 102 hips (group II, 97 patients). Group I consisted of 47 females and 17 males with average age of 66 years (range 29-84 years). Group II included 60 females and 37 males with average age of 70 years (range 48-89 years).
RESULTS: Dislocation occurred in six hips (9.1%) of group I and in seven hips (6.8%) of group II (P = 0.401). Dislocations were observed early in both groups, except one hip in group II that dislocated 434 days postoperatively and required surgical reduction. All other dislocations were treated by closed reduction. No recurrence was observed.
CONCLUSIONS: The use of an increased-modularity revision stem alone did not prove to be effective in reducing the risk of postoperative dislocation.

Introduction

Dislocation is an important local complication after total hip arthroplasty (THA), with a considerably higher incidence in revision surgery [1, 2].

Among risk factors associated with hip dislocation, femoral and/or acetabular component malposition and poor restoration of appropriate muscular tension play a primary role [1-3].

In femoral revision, the use of a fluted, tapered stem developed by Wagner [4, 5] allowed successful treatment even in cases complicated by extensive proximal bone loss, thanks to adequate distal fixation. The Wagner revision stem joined regularly the occurrence of periprosthetic new bone formation [5-15] but exhibited two major drawbacks: the risk of stem subsidence [6, 7, 9–11, 13] and high incidence of dislocation, as much as 20% in some case series [6, 7, 9, 11–14].

In revision surgery, femoral bone loss is highly variable, and restoration of the femoral head center at the correct length, offset, and anteversion with soft tissue balance may be difficult to achieve [9]. Consequently, increased-modularity cementless stems have been developed to solve these issues; they consist of several parts that can be assembled to change the orientation of every component and correct the version, length, and offset to promote proper soft tissue tension [16-19]. The aim of this study is to evaluate retrospectively if the early dislocation rate after revision THA could be reduced using an uncemented increased-modularity revision stem.

Materials and methods

Between September 1992 and April 2007, 171 THA revisions in 164 patients were performed using in all cases an uncemented tapered stem. The main reason for operation was aseptic loosening. Other indications included periprosthetic fracture, second-stage surgery following infection, and femoral stem breakage. No case of prosthetic instability was treated. During the first period, from September 1992 to March 1998, a standard-modularity femoral component (Wagner SL, Sulzer Orthopedics Ltd., Winterthur, Switzerland) was used in 68 hips in 66 patients (two bilateral implants). Later, from May 1995 to April 2007, an increased-modularity stem (Profemur R, Wright Medical Technology, Arlington, TN) was used in 103 hips in 98 patients (five bilateral implants).

The Wagner SL stem is available in four sizes and is conically shaped in the distal part, with eight longitudinal antirotational ribs. Three different head lengths are available; a 32-mm-diameter femoral head was used in all cases. Profemur R is a modular prosthesis that consists of a tapered diaphyseal stem with cutting flutes and a rough surface, and a metaphyseal double-cone body, connected via a Morse taper and a securing screw. The modularity is completed by the availability of three different length heads and interchangeable necks with different length and version, which allow different offset and version to be obtained; in all cases a 28-mm-diameter femoral head was implanted.

Revision surgery was performed with the patient in supine position under general anesthesia; an anterolateral approach without osteotomy of the greater trochanter was carried out. After removing the prosthesis and accurately cleaning the bone surfaces, the acetabular cup was revised first, followed by the femoral stem.

All patients underwent a rehabilitation programme with isometric muscle training and exercises of supported active and passive motion of the limb from the second day after surgery. Ambulation with two crutches started after 1 week, allowing partial weight bearing after 1 month and unrestrained walking 4–6 months after surgery.

Clinical data collected on all patients included presence or absence of dislocation and time to dislocation. Checks for dislocation continued up to 2 years following surgery; after this period, dislocation can be considered infrequent [20]. All patients gave informed consent to be included in the study, and the study was authorized by the local ethical committee and was performed in accordance with the ethical standards of the 1964 Declaration of Helsinki as revised in 2000.

In the Wagner and Profemur groups, respectively, two and one cases were excluded, because dislocation occurred with stem subsidence >10 mm [13]. Finally, 168 hips in 161 patients were available. This study consisted of a first group (group I) treated with a Wagner standard-modularity prosthesis, including 66 hips in 64 patients (18 males and 48 females) with average age of 66 years (range 29–84 years), and a second group (group II) of 102 revisions in 97 patients (65 males and 37 females) with average age of 70 years (range 48–89 years) who received a Profemur R increased-modularity stem (Table 1). Revision surgery included acetabular replacement in all but three and two cases in group I and II, respectively.

Table 1

Patient data

	Males (hips)	Females (hips)	Age* (years)
Group I	18	48	66.14 ± 13.01
Group II	37	65	70.70 ± 9.01
Tests of intergroup difference	P = 0.295†

*Values are mean ± standard deviation

†Chi-square test

Intergroup chi-square testing was used to distinguish statistically between study data as regards patient gender distribution. Fisher’s exact probability test was used to compare intergroup hip dislocation rate and to distinguish any statistically significant difference that may have existed as regards early THA dislocation rate. A P value ≤0.05 was considered significant.

Results

Postoperative hip dislocation occurred for 6 (9.1%) of 66 hips in which a standard-modularity stem was used (group I). The postoperative course of the patients who received an increased-modularity prosthesis (group II) was complicated by dislocation in 7 (6.8%) of 102 hips (P = 0,401; Table 2). In both groups dislocation was treated with closed reduction (except one case that required open reduction) and immobilization by means of orthopedic brace for 1 month. Dislocation was observed early in the postoperative, from 12 to 24 days after the operation, in group I. Even in group II this complication occurred early, from 14 to 29 days postoperatively, except one hip that dislocated 434 days after operation and required open reduction. No recurrent dislocation was observed.

Table 2

Dislocation rate

	Dislocations (%)	Nondislocations (%)
Group I	6 (9.1%)	60 (90.9%)
Group II	7 (6.8%)	95 (93.2%)
Tests of intergroup difference	P = 0.401†

†Fisher’s exact probability test

Discussion

Dislocation is a troublesome and disabling complication, occurring in 1–3% after primary THA and in 7–10% after revision hip surgery [1, 2]. Alberton and coworkers [3] evaluated risk factors leading to hip instability and stated that dislocation after revision arthroplasty has different causes than those after primary THA.

The higher dislocation rate of revision THA may be related to soft tissue deficiencies. Boucher et al. [21] evaluated acetabular polyethylene liner exchange in patients without previous dislocation. A postoperative dislocation rate of 25% was found, demonstrating that re-establishing adequate soft tissue tension and range of motion without impingement was essential in avoiding an unstable THA. Re-establishment of femoral offset in total hip replacement restores biomechanics of the hip and soft tissue balance, and may reduce dislocation risk. Procenca and Cabral [22] used two monoblock taper stems with different offset, the Wagner stem (145° CCD angle) and the Conelock stem (135° CCD angle), reporting a decrease of dislocation rate from 12% to 3%, respectively.

Moreover, morphologic changes of the proximal femur make revision THA a demanding procedure. Monoblock fluted and tapered stems provide stable axial fixation in the distal femur and excellent rotational stability, promoting spontaneous formation of new bone at the site of the defect [6, 7, 9, 11–15]. However, the main problem is related to lack of versatility in terms of version and offset. Weber et al. [9] reported five dislocations in 40 revision hip arthroplasties using the Wagner stem and suggested two main reasons for these dislocations: lack of active soft tissue tension related to abductor muscle atrophy, and low offset of the prosthesis, which results in impingement of the trochanteric region into the pelvis. Several studies involving the use of an increased-modularity stem demonstrated the possibility to adjust leg length, offset, neck length, and version during revision surgery [17-19]. Kopec et al. [23] examined 21 THA revisions using a modular stem and, through a computer-aided design (CAD) system reconstruction, the range of femoral component positioning was evaluated. Only in one case (5%) was the stem orientation similar to that of a nonmodular prosthesis, indicating that neck and metaphysis version often needed to be established independently from stem placement.

In our comparative series, the rate of dislocation decreased from 9.1% in the group of patients who received a standard-modularity stem to 6.8% after the introduction of a modular implant, even if the result was not statistically significant (P = 0.401). Our data are similar to those of several clinical studies, with a dislocation rate in revision surgery ranging from 2.1% to 20.9% with standard monoblock stems and from 1.3% to 11.3% with increased-modularity stems (Tables 3, 4). Furthermore, to our knowledge no case series is available reporting the dislocation rate through a direct comparison between monoblock and modular stems.

Table 3

Dislocation rate with standard-modularity tapered stem

Reference	Stem	No. of hips	Dislocations (%)
Bartolozzi et al. [6]	Wagner SL	50	12
Wagner and Wagner [5]	Wagner SL	69	2.9
Isacson et al. [7]	Wagner SL	43	20.9
Bircher et al. [8]	Wagner SL	99	4.1
Boisgard et al. [14]	Wagner SL	52	7.8
Weber et al. [9]	Wagner SL	40	12.5
Ferruzzi et al. [10]	Wagner SL	350	4
Böhm and Bischel [11]	Wagner SL	129	5.4
Gutiérrez del Alamo et al. [12]	Wagner SL	79	13.9
Mantelos et al. [15]	Wagner SL	82	2.1

Table 4

Dislocation rate with increased-modularity tapered stem

Reference	Stem	No. of hips	Dislocations (%)
Wirtz et al. [27]	MRP-Titan	142	11.3
Kwong et al. [34]	MP	143	2.1
Park et al. [36]	Lima-Lto	62	5
Kang et al. [17]	ZMR taper	47	2.1
Rodriguez et al. [19]	MP	97	10.3
Köster et al. [37]	Profemur-R	73	1.3
Ovesen et al. [38]	ZMR taper	125	6.4

A preliminary evaluation of the dislocation rate that we observed with the same models of tapered stems (monoblock and increased modularity) was already reported [24]. Though the difference between the two groups of patients was not significant, the given trend led us to assume that modularity could decrease the rate of dislocation in revision hip surgery. However, based on the data that we finally obtained when performing a longer-term assessment, we actually consider that stem modularity alone is not helpful.

The modular prosthesis we used, Profemur R, in addition to the availability of proximal and distal parts and heads, offers the peculiarity of an interchangeable neck, which means it is possible to modify the final length and orientation of the prosthesis. The use of a proximal modular prosthesis at the time of further operations greatly simplifies strategies for revision surgery since the modular components can be removed, facilitating exposure and allowing for changes in offset, leg length, and anteversion without the need for revising the distal femoral component [25-27]. Wirtz et al. [28] presented early results of 142 uncemented femoral stem revisions using the modular MRP-Titan system, reporting five cases of recurrent dislocation (3.5%) which were successfully managed by modifying the angle of anteversion without changing out the distal portion of the stem.

Among the possible drawbacks of modularity is the larger number of parts, which could result in risk of fracture, dissociation, and mismatching of components and greater production of metallic debris due to friction of the components [29, 30]. Laboratory tests proved that modular prosthesis can be considered a reliable solution when several parts of the implant are correctly coupled [31]. This is supported as more and more clinical medium-term outcomes document the validity of modularity in femoral revision, with high survival rates [32-39].

Certainly, the present study has a series of weaknesses. It was a retrospective analysis, and patients were not randomized. The number of cases in each group was small and not homogeneous in terms of age and especially gender (with a higher rate of females in group I). Furthermore, we did not evaluate other well-known risk factors for dislocation, such as the number of surgeries, the type of approach, and the orientation of the acetabular component.

In conclusion, modularity provides the possibility to facilitate the intraoperative choice of the femoral version, length, and offset, independently of distal fixation. However, the use of an increased-modularity revision stem alone does not seem to be effective in reducing the risk of postoperative dislocation.