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Literature DB >> 18926697

RNA bandages for photoregulating in vitro protein synthesis.

Julia L Richards¹, XinJing Tang, Anna Turetsky, Ivan J Dmochowski.

Abstract

'RNA bandages' are composed of two 6-12-mer 2'-OMe RNA strands complementary to a mRNA target that are joined by a photocleavable linker. These tandem oligonucleotides typically exhibit much higher affinity for the mRNA than the individual strands. An RNA bandage with binding arms of different lengths and a 4-base gap blocked translation in vitro of GFP mRNA; subsequent near-UV irradiation restored translation. This provides a general method of photomodulating hybridization for a variety of oligonucleotide-based technologies.

Entities: Chemical Disease Gene Species

Mesh：

Substances：

Year: 2008 PMID： 18926697 PMCID： PMC2593108 DOI： 10.1016/j.bmcl.2008.09.093

Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823

33 in total

1. A universal, photocleavable DNA base: nitropiperonyl 2'-deoxyriboside.

Authors: M C Pirrung; X Zhao; S V Harris
Journal: J Org Chem Date: 2001-03-23 Impact factor: 4.354

2. Triggering DNAzymes with light: a photoactive C8 thioether-linked adenosine.

Authors: Richard Ting; Leonard Lermer; David M Perrin
Journal: J Am Chem Soc Date: 2004-10-13 Impact factor: 15.419

Review 3. Regulation of translation via mRNA structure in prokaryotes and eukaryotes.

Authors: Marilyn Kozak
Journal: Gene Date: 2005-10-05 Impact factor: 3.688

4. Controlling RNA digestion by RNase H with a light-activated DNA hairpin.

Authors: Xinjing Tang; Ivan J Dmochowski
Journal: Angew Chem Int Ed Engl Date: 2006-05-19 Impact factor: 15.336

5. Light-controlled gene silencing in zebrafish embryos.

Authors: Ilya A Shestopalov; Surajit Sinha; James K Chen
Journal: Nat Chem Biol Date: 2007-08-23 Impact factor: 15.040

6. Caged RNA: photo-control of a ribozyme reaction.

Authors: S G Chaulk; A M MacMillan
Journal: Nucleic Acids Res Date: 1998-07-01 Impact factor: 16.971

7. Photo-mediated gene activation using caged RNA/DNA in zebrafish embryos.

Authors: H Ando; T Furuta; R Y Tsien; H Okamoto
Journal: Nat Genet Date: 2001-08 Impact factor: 38.330

8. Targeting expression with light using caged DNA.

Authors: W T Monroe; M M McQuain; M S Chang; J S Alexander; F R Haselton
Journal: J Biol Chem Date: 1999-07-23 Impact factor: 5.157

9. Photomodulation of PS-modified oligonucleotides containing azobenzene substituent at pre-selected positions in phosphate backbone.

Authors: Satyakam Patnaik; P Kumar; B S Garg; R P Gandhi; K C Gupta
Journal: Bioorg Med Chem Date: 2007-08-28 Impact factor: 3.641

10. 3-nitro-3-deaza-2'-deoxyadenosine as a versatile photocleavable 2'-deoxyadenosine mimic.

Authors: Caroline Crey-Desbiolles; Jean Lhomme; Pascal Dumy; Mitsuharu Kotera
Journal: J Am Chem Soc Date: 2004-08-11 Impact factor: 15.419

17 in total

Review 1. Optochemical Control of Biological Processes in Cells and Animals.

Authors: Nicholas Ankenbruck; Taylor Courtney; Yuta Naro; Alexander Deiters
Journal: Angew Chem Int Ed Engl Date: 2018-02-01 Impact factor: 15.336

2. Activation and deactivation of DNAzyme and antisense function with light for the photochemical regulation of gene expression in mammalian cells.

Authors: Douglas D Young; Mark O Lively; Alexander Deiters
Journal: J Am Chem Soc Date: 2010-05-05 Impact factor: 15.419

RNA bandages for photoregulating in vitro protein synthesis.

1. A universal, photocleavable DNA base: nitropiperonyl 2'-deoxyriboside.

2. Triggering DNAzymes with light: a photoactive C8 thioether-linked adenosine.

Review 3. Regulation of translation via mRNA structure in prokaryotes and eukaryotes.

4. Controlling RNA digestion by RNase H with a light-activated DNA hairpin.

5. Light-controlled gene silencing in zebrafish embryos.

6. Caged RNA: photo-control of a ribozyme reaction.

7. Photo-mediated gene activation using caged RNA/DNA in zebrafish embryos.

8. Targeting expression with light using caged DNA.

9. Photomodulation of PS-modified oligonucleotides containing azobenzene substituent at pre-selected positions in phosphate backbone.

10. 3-nitro-3-deaza-2'-deoxyadenosine as a versatile photocleavable 2'-deoxyadenosine mimic.

Review 1. Optochemical Control of Biological Processes in Cells and Animals.

2. Activation and deactivation of DNAzyme and antisense function with light for the photochemical regulation of gene expression in mammalian cells.

Review 3. Caged oligonucleotides for studying biological systems.

Review 4. Translational control of gene function through optically regulated nucleic acids.

5. Photomodulating RNA cleavage using photolabile circular antisense oligodeoxynucleotides.

Review 6. Light activation as a method of regulating and studying gene expression.

7. Optochemical control of deoxyoligonucleotide function via a nucleobase-caging approach.

8. Caged oligonucleotides for bidirectional photomodulation of let-7 miRNA in zebrafish embryos.

9. Principles and applications of the photochemical control of cellular processes.

10. Versatile synthesis and rational design of caged morpholinos.