Literature DB >> 23721917

Caged oligonucleotides for bidirectional photomodulation of let-7 miRNA in zebrafish embryos.

Julianne C Griepenburg1, Brittani K Ruble, Ivan J Dmochowski.   

Abstract

Many biological functions of microRNA (miRNA) have been identified in the past decade. However, a single miRNA can regulate multiple gene targets, thus it has been a challenge to elucidate the specific functions of each miRNA in different locations and times. New chemical tools make it possible to modulate miRNA activity with higher spatiotemporal resolution. Here, we describe light-activated (caged) constructs for switching let-7 miRNA 'on' or 'off' with 365 nm light in developing zebrafish embryos.
Copyright © 2013 Elsevier Ltd. All rights reserved.

Entities:  

Keywords:  Antagomir; Let-7; MicroRNA (miRNA); Zebrafish

Mesh：

Substances：

Year:  2013        PMID： 23721917      PMCID： PMC3789856          DOI： 10.1016/j.bmc.2013.04.082

Source DB:  PubMed          Journal:  Bioorg Med Chem        ISSN： 0968-0896            Impact factor:   3.641


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