Literature DB >> 1267429

Phosphonoacetic acid in the treatment of experimental ocular herpes simplex infections.

R F Meyer, E D Varnell, H E Kaufman.   

Abstract

Phosphonoacetic acid had a significant antiviral effect when applied topically, both in liquid and ointment preparations, on superficial herpetic keratitis in rabbits and was equally as effective as idoxuridine. It was also effective in the treatment of idoxuridine-resistant herpetic keratitis. Phosphonoacetic acid was not effective in the treatment of experimental herpetic iritis when applied topically but was significantly effective when administered intravenously and subconjunctivally. No significant local or systemic toxicity was encountered.

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Year:  1976        PMID： 1267429      PMCID： PMC429519          DOI： 10.1128/AAC.9.2.308

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  8 in total

1.  Inhibition of herpes simplex virus replication by phosphonoacetic acid.

Authors:  L R Overby; E E Robishaw; J B Schleicher; A Rueter; N L Shipkowitz; J C Mao
Journal:  Antimicrob Agents Chemother       Date:  1974-09       Impact factor: 5.191

2.  Phosphonoacetic acid-resistant herpes simplex virus infection in hairless mice.

Authors:  R J Klein; A E Friedman-Kien
Journal:  Antimicrob Agents Chemother       Date:  1975-03       Impact factor: 5.191

3.  Phosphonoacetic acid in the treatment of experimental herpes simplex keratitis.

Authors:  D D Gerstein; C R Dawson; J O O
Journal:  Antimicrob Agents Chemother       Date:  1975-03       Impact factor: 5.191

4.  Development of resistance to antiviral drugs.

Authors:  H E Renis; D A Buthala
Journal:  Ann N Y Acad Sci       Date:  1965-07-30       Impact factor: 5.691

5.  Trifluorothymidine treatment of herpetic iritis in rabbits and ocular penetration.

Authors:  J Sugar; E Varnell; Y Centifanto; H E Kaufman
Journal:  Invest Ophthalmol       Date:  1973-07

6.  Intravenous adenine arabinoside against herpes simplex keratouveitis in humans.

Authors:  R Abel; H E Kaufman; J Sugar
Journal:  Am J Ophthalmol       Date:  1975-04       Impact factor: 5.258

7.  Inhibition of DNA polymerase from herpes simplex virus-infected wi-38 cells by phosphonoacetic Acid.

Authors:  J C Mao; E E Robishaw; L R Overby
Journal:  J Virol       Date:  1975-05       Impact factor: 5.103

8.  Suppression of herpes simplex virus infection by phosphonoacetic acid.

Authors:  N L Shipkowitz; R R Bower; R N Appell; C W Nordeen; L R Overby; W R Roderick; J B Schleicher; A M Von Esch
Journal:  Appl Microbiol       Date:  1973-09
  8 in total
  12 in total

1.  Deoxyribonucleic acid polymerase of wild-type and phosphonoacetic acid-resistant mutant of herpes simplex virus.

Authors:  B Fridlender; N Chejanovsky; Y Becker
Journal:  Antimicrob Agents Chemother       Date:  1978-01       Impact factor: 5.191

2.  Alteration of mortality and pathogenesis of three experimental Herpesvirus hominis infections of mice with adenine arabinoside 5'-monophosphate, adenine arabinoside, and phosphonoacetic acid.

Authors:  E R Kern; J T Richards; J C Overall; L A Glasgow
Journal:  Antimicrob Agents Chemother       Date:  1978-01       Impact factor: 5.191

3.  Treatment of experimental herpesvirus infections with phosphonoformate and some comparisons with phosphonoacetate.

Authors:  E R Kern; L A Glasgow; J C Overall; J M Reno; J A Boezi
Journal:  Antimicrob Agents Chemother       Date:  1978-12       Impact factor: 5.191

4.  A combined chemical-physical treatment for herpes simplex lesions in guinea pigs.

Authors:  T A Brawner; J E Senne; M Fahim
Journal:  Arch Dermatol Res       Date:  1979-05-29       Impact factor: 3.017

5.  Phosphonoacetic Acid inhibition of frog virus 3 replication.

Authors:  R M Elliott; A Bateson; D C Kelly
Journal:  J Virol       Date:  1980-01       Impact factor: 5.103

6.  Structure-activity studies on phosphonoacetate.

Authors:  J C Mao; E R Otis; A M von Esch; T R Herrin; J S Fairgrieve; N L Shipkowitz; R G Duff
Journal:  Antimicrob Agents Chemother       Date:  1985-02       Impact factor: 5.191

7.  Phosphonoacetic acid-resistant mutants of herpes simplex virus: effect of phosphonoacetic acid on virus replication and in vitro deoxyribonucleic acid synthesis in isolated nuclei.

Authors:  Y Becker; Y Asher; Y Cohen; E Weinberg-Zahlering; J Shlomai
Journal:  Antimicrob Agents Chemother       Date:  1977-05       Impact factor: 5.191

8.  Immune response and latent infection after topical treatment of herpes simplex virus infection in hairless mice.

Authors:  R J Klein; A E Friedman-Kien; A A Fondak; E Buimovici-Klein
Journal:  Infect Immun       Date:  1977-06       Impact factor: 3.441

9.  Effect of phosphonoacetic acid in the treatment of experimental herpes simplex keratitis.

Authors:  Y J Gordon; M Lahav; S Photiou; Y Becker
Journal:  Br J Ophthalmol       Date:  1977-08       Impact factor: 4.638

10.  Comparative studies of interferon and three antiviral agents on neurotropic and oncogenic herpesviruses.

Authors:  M D Daniel; L A Falk; N W King; R Tamulevich; J S Holland; J G Bekesi
Journal:  Antimicrob Agents Chemother       Date:  1980-10       Impact factor: 5.191
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