Literature DB >> 195514

Phosphonoacetic acid-resistant mutants of herpes simplex virus: effect of phosphonoacetic acid on virus replication and in vitro deoxyribonucleic acid synthesis in isolated nuclei.

Y Becker, Y Asher, Y Cohen, E Weinberg-Zahlering, J Shlomai.   

Abstract

Phosphonoacetic acid (PAA) inhibits the replication of herpes simplex virus in BSC-1 cells and the in vitro synthesis of deoxyribonucleic acid (DNA) in isolated nuclei. Phosphonopropionic acid at a concentration of 100 mug/ml had no effect on herpes simplex virus replication. PAA-resistant mutants were obtained at a rate of 1 in 10(4) plaque-forming units after 5-bromodeoxyuridine mutagenization of the virus. These mutants replicate in BSC-1 cells in the presence of 100 mug of PAA per ml and induce a PAA-resistant DNA polymerase that synthesizes DNA in vitro in the presence of PAA.

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Year:  1977        PMID： 195514      PMCID： PMC352099          DOI： 10.1128/AAC.11.5.919

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  15 in total

1.  Inhibition of herpes simplex virus replication by phosphonoacetic acid.

Authors:  L R Overby; E E Robishaw; J B Schleicher; A Rueter; N L Shipkowitz; J C Mao
Journal:  Antimicrob Agents Chemother       Date:  1974-09       Impact factor: 5.191

2.  In vitro synthesis of DNA in nuclei isolated from herpes simplex virus-infected cells, untreated and treated with metabolic inhibitors.

Authors:  Y Becker; Y Asher
Journal:  Virology       Date:  1975-01       Impact factor: 3.616

3.  Inhibition of Epstein-Barr virus DNA synthesis and late gene expression by phosphonoacetic acid.

Authors:  W C Summers; G Klein
Journal:  J Virol       Date:  1976-04       Impact factor: 5.103

4.  Phosphonoacetic acid in the treatment of experimental ocular herpes simplex infections.

Authors:  R F Meyer; E D Varnell; H E Kaufman
Journal:  Antimicrob Agents Chemother       Date:  1976-02       Impact factor: 5.191

5.  The effect of cytosine arabinoside on the replication of herpes simplex virus.

Authors:  J Levitt; Y Becker
Journal:  Virology       Date:  1967-01       Impact factor: 3.616

6.  Inhibition of DNA polymerase from herpes simplex virus-infected wi-38 cells by phosphonoacetic Acid.

Authors:  J C Mao; E E Robishaw; L R Overby
Journal:  J Virol       Date:  1975-05       Impact factor: 5.103

7.  Mutants of herpes simplex virus types 1 and 2 that are resistant to phosphonoacetic acid induce altered DNA polymerase activities in infected cells.

Authors:  J Hay; J H Subak-Sharpe
Journal:  J Gen Virol       Date:  1976-04       Impact factor: 3.891

8.  Mode of inhibition of herpes simplex virus DNA polymerase by phosphonoacetate.

Authors:  J C Mao; E E Robishaw
Journal:  Biochemistry       Date:  1975-12-16       Impact factor: 3.162

9.  Mechanism of phosphonoacetate inhibition of herpesvirus-induced DNA polymerase.

Authors:  S S Leinbach; J M Reno; L F Lee; A F Isbell; J A Boezi
Journal:  Biochemistry       Date:  1976-01-27       Impact factor: 3.162

10.  Suppression of herpes simplex virus infection by phosphonoacetic acid.

Authors:  N L Shipkowitz; R R Bower; R N Appell; C W Nordeen; L R Overby; W R Roderick; J B Schleicher; A M Von Esch
Journal:  Appl Microbiol       Date:  1973-09
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  11 in total

1.  Herpes simplex virus DNA polymerase, thymidine kinase and deoxyribonuclease activities in cells infected with wild type, ultraviolet-irradiated and defective virus.

Authors:  Y Becker; B Gutter; Y Cohen; N Chejanovsky; S Rabkin; B Fridlender
Journal:  Arch Virol       Date:  1979       Impact factor: 2.574

2.  Deoxyribonucleic acid polymerase of wild-type and phosphonoacetic acid-resistant mutant of herpes simplex virus.

Authors:  B Fridlender; N Chejanovsky; Y Becker
Journal:  Antimicrob Agents Chemother       Date:  1978-01       Impact factor: 5.191

3.  Infection of cultured bovine cells with bovine herpesvirus 1 (BHV-1) or Sendai virus induces different beta interferon subtypes.

Authors:  Leticia Frizzo da Silva; Clinton Jones
Journal:  Virus Res       Date:  2011-02-23       Impact factor: 3.303

4.  Roscovitine, a specific inhibitor of cellular cyclin-dependent kinases, inhibits herpes simplex virus DNA synthesis in the presence of viral early proteins.

Authors:  L M Schang; A Rosenberg; P A Schaffer
Journal:  J Virol       Date:  2000-03       Impact factor: 5.103

5.  Requirement for cellular cyclin-dependent kinases in herpes simplex virus replication and transcription.

Authors:  L M Schang; J Phillips; P A Schaffer
Journal:  J Virol       Date:  1998-07       Impact factor: 5.103

6.  Cellular localization of the herpes simplex virus ICP0 protein dictates its ability to block IRF3-mediated innate immune responses.

Authors:  Patrick Paladino; Susan E Collins; Karen L Mossman
Journal:  PLoS One       Date:  2010-04-29       Impact factor: 3.240

7.  Isolation and preliminary characterization of a phosphonoacetic acid-resistant and temperature-sensitive mutant of herpes simplex virus type 1.

Authors:  J I Daksis; M M Priemer; V L Chan
Journal:  J Virol       Date:  1982-04       Impact factor: 5.103

8.  The HIV Integrase Inhibitor Raltegravir Inhibits Felid Alphaherpesvirus 1 Replication by Targeting both DNA Replication and Late Gene Expression.

Authors:  Matthew R Pennington; Ian E H Voorhees; Heather M Callaway; Shannon D Dehghanpir; Joel D Baines; Colin R Parrish; Gerlinde R Van de Walle
Journal:  J Virol       Date:  2018-09-26       Impact factor: 5.103

9.  BHV-1 induced oxidative stress contributes to mitochondrial dysfunction in MDBK cells.

Authors:  Liqian Zhu; Chen Yuan; Dong Zhang; Yan Ma; Xiuyan Ding; Guoqiang Zhu
Journal:  Vet Res       Date:  2016-03-22       Impact factor: 3.683

10.  The role of phospholipase C signaling in bovine herpesvirus 1 infection.

Authors:  Liqian Zhu; Chen Yuan; Xiuyan Ding; Clinton Jones; Guoqiang Zhu
Journal:  Vet Res       Date:  2017-09-07       Impact factor: 3.683
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