Literature DB >> 199232

Effect of phosphonoacetic acid in the treatment of experimental herpes simplex keratitis.

Y J Gordon, M Lahav, S Photiou, Y Becker.   

Abstract

In the rabbit 5% phosphonoacetic acid ointment suppressed herpetic keratitis as well as 0-5% idoxuridine ointment. After 5 days of treatment quantitative virus titres showed that phosphonoacetic acid was superior to idoxuridine in the inhibition of herpes virus replication. Phosphonoacetic acid was found to be nontoxic to the eye in both clinical and histopathological studies. Recent reports suggest that the mechanism of action of phosphonoacetic acid appears to be the blocking of the virus DNA polymerase, which is essential for the synthesis of herpes virus DNA.

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Year:  1977        PMID： 199232      PMCID： PMC1043027          DOI： 10.1136/bjo.61.8.506

Source DB:  PubMed          Journal:  Br J Ophthalmol        ISSN： 0007-1161            Impact factor:   4.638


  16 in total

1.  IDU therapy of herpes simplex.

Authors:  H E KAUFMAN; A B NESBURN; E D MALONEY
Journal:  Arch Ophthalmol       Date:  1962-05

2.  Synthesis and biological activity of some novel analogs of thymidine.

Authors:  Y C Cheng; J P Neenan; B Goz; D C Ward; W H Prusoff
Journal:  Ann N Y Acad Sci       Date:  1975-08-08       Impact factor: 5.691

3.  Inhibition of herpes simplex virus replication by phosphonoacetic acid.

Authors:  L R Overby; E E Robishaw; J B Schleicher; A Rueter; N L Shipkowitz; J C Mao
Journal:  Antimicrob Agents Chemother       Date:  1974-09       Impact factor: 5.191

4.  The effect of cytosine arabinoside on the replication of herpes simplex virus.

Authors:  J Levitt; Y Becker
Journal:  Virology       Date:  1967-01       Impact factor: 3.616

5.  Mutants of herpes simplex virus types 1 and 2 that are resistant to phosphonoacetic acid induce altered DNA polymerase activities in infected cells.

Authors:  J Hay; J H Subak-Sharpe
Journal:  J Gen Virol       Date:  1976-04       Impact factor: 3.891

6.  Adenine arabinoside in idoxuridine unresponsive and intolerant herpetic keratitis.

Authors:  R A Hyndiuk; D S Hull; R O Schultz; G N Chin
Journal:  Am J Ophthalmol       Date:  1975-04       Impact factor: 5.258

7.  Mode of inhibition of herpes simplex virus DNA polymerase by phosphonoacetate.

Authors:  J C Mao; E E Robishaw
Journal:  Biochemistry       Date:  1975-12-16       Impact factor: 3.162

8.  Mechanism of phosphonoacetate inhibition of herpesvirus-induced DNA polymerase.

Authors:  S S Leinbach; J M Reno; L F Lee; A F Isbell; J A Boezi
Journal:  Biochemistry       Date:  1976-01-27       Impact factor: 3.162

9.  Use of 5-iodo-2'-deoxyuridine (IDU) in treatment of herpes simplex keratitis.

Authors:  H KAUFMAN; E L MARTOLA; C DOHLMAN
Journal:  Arch Ophthalmol       Date:  1962-08

10.  Suppression of herpes simplex virus infection by phosphonoacetic acid.

Authors:  N L Shipkowitz; R R Bower; R N Appell; C W Nordeen; L R Overby; W R Roderick; J B Schleicher; A M Von Esch
Journal:  Appl Microbiol       Date:  1973-09
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