Literature DB >> 204249

Deoxyribonucleic acid polymerase of wild-type and phosphonoacetic acid-resistant mutant of herpes simplex virus.

B Fridlender, N Chejanovsky, Y Becker.   

Abstract

The phosphonacetic acid (PAA)-susceptible deoxyribonucleic acid (DNA) polymerase of herpes simplex virus type 1 was partially purified and isolated in sucrose gradients and on double-strand DNA cellulose columns. The DNA polymerase isolated from cells infected with the PAA-resistant mutant had the same molecular weight as the wild-type enzyme (140,000 to 149,000) but was consistently more resistant to PAA.

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Year:  1978        PMID： 204249      PMCID： PMC352195          DOI： 10.1128/AAC.13.1.124

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  13 in total

1.  Inhibition of Epstein-Barr virus DNA synthesis and late gene expression by phosphonoacetic acid.

Authors:  W C Summers; G Klein
Journal:  J Virol       Date:  1976-04       Impact factor: 5.103

2.  Phosphonoacetic acid in the treatment of experimental ocular herpes simplex infections.

Authors:  R F Meyer; E D Varnell; H E Kaufman
Journal:  Antimicrob Agents Chemother       Date:  1976-02       Impact factor: 5.191

3.  Phosphonoacetic acid in the treatment of experimental herpes simplex keratitis.

Authors:  D D Gerstein; C R Dawson; J O O
Journal:  Antimicrob Agents Chemother       Date:  1975-03       Impact factor: 5.191

4.  Characterization of herpes simplex virus-induced deoxyribonucleic acid polymerase.

Authors:  A Weissbach; S C Hong; J Aucker; R Muller
Journal:  J Biol Chem       Date:  1973-09-25       Impact factor: 5.157

5.  Mutants of herpes simplex virus types 1 and 2 that are resistant to phosphonoacetic acid induce altered DNA polymerase activities in infected cells.

Authors:  J Hay; J H Subak-Sharpe
Journal:  J Gen Virol       Date:  1976-04       Impact factor: 3.891

6.  Human cytomegalovirus. IV. Specific inhibition of virus-induced DNA polymerase activity and viral DNA replication by phosphonoacetic acid.

Authors:  E S Huang
Journal:  J Virol       Date:  1975-12       Impact factor: 5.103

7.  Mode of inhibition of herpes simplex virus DNA polymerase by phosphonoacetate.

Authors:  J C Mao; E E Robishaw
Journal:  Biochemistry       Date:  1975-12-16       Impact factor: 3.162

8.  Mechanism of phosphonoacetate inhibition of herpesvirus-induced DNA polymerase.

Authors:  S S Leinbach; J M Reno; L F Lee; A F Isbell; J A Boezi
Journal:  Biochemistry       Date:  1976-01-27       Impact factor: 3.162

9.  Phosphonoacetic acid-resistant mutants of herpes simplex virus: effect of phosphonoacetic acid on virus replication and in vitro deoxyribonucleic acid synthesis in isolated nuclei.

Authors:  Y Becker; Y Asher; Y Cohen; E Weinberg-Zahlering; J Shlomai
Journal:  Antimicrob Agents Chemother       Date:  1977-05       Impact factor: 5.191

10.  Induction of alpha type DNA polymerases in human cytomegalovirus-infected WI-38 cells.

Authors:  K Hirai; Y Watanabe
Journal:  Biochim Biophys Acta       Date:  1976-10-18
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  1 in total

1.  Herpes simplex virus DNA polymerase, thymidine kinase and deoxyribonuclease activities in cells infected with wild type, ultraviolet-irradiated and defective virus.

Authors:  Y Becker; B Gutter; Y Cohen; N Chejanovsky; S Rabkin; B Fridlender
Journal:  Arch Virol       Date:  1979       Impact factor: 2.574
  1 in total

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