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Literature DB >> 15830487

Inhibition of herpes simplex virus replication by phosphonoacetic acid.

L R Overby, E E Robishaw, J B Schleicher, A Rueter, N L Shipkowitz, J C Mao.

Abstract

Replication of herpes simplex virus in WI-38 cells was inhibited by phosphonoacetic acid, as measured by decreased virus cytopathogenic effect and incorporation of radiolabeled thymidine in virus-infected cells. The drug appeared to have no effect on adsorption, penetration, or release of the virus nor on the synthesis of ribonucleic acid or protein. It appeared to inhibit virus deoxyribonucleic acid synthesis.

Entities: Chemical

Mesh：

Substances：

Year: 1974 PMID： 15830487 PMCID： PMC444651 DOI： 10.1128/AAC.6.3.360

Source DB: PubMed Journal: Antimicrob Agents Chemother ISSN： 0066-4804 Impact factor: 5.191

11 in total

1. Antibodies to Epstein-Barr virus in nasopharyngeal carcinoma, other head and neck neoplasms, and control groups.

Authors: W Henle; G Henle; H C Ho; P Burtin; Y Cachin; P Clifford; A de Schryver; G de-Thé; V Diehl; G Klein
Journal: J Natl Cancer Inst Date: 1970-01 Impact factor: 13.506

2. THE MULTIPLICATION OF HERPES SIMPLEX VIRUS. I. THE PROGRAMMING OF VIRAL DNA DUPLICATION IN HEP-2 CELLS.

Authors: B ROIZMAN; L AURELIAN; P R ROANE
Journal: Virology Date: 1963-11 Impact factor: 3.616

3. Role of herpesviruses in Marek's disease, a malignant lymphoma of chickens.

Authors: H G Purchase
Journal: Fed Proc Date: 1972 Nov-Dec

4. Herpesviruses saimiri and ateles--their role in malignant lymphomas of monkeys.

Authors: L V Melèndez; R D Hunt; M D Daniel; C E Fraser; H H Barahona; N W King; F G Garcìa
Journal: Fed Proc Date: 1972 Nov-Dec

5. Possible role of Herpesvirus hominis, type 2, in human cervical cancer.

Authors: L Aurelian
Journal: Fed Proc Date: 1972 Nov-Dec

6. Role of herpesviruses in malignant lymphoma in rabbits.

Authors: H C Hinze; P J Chipman
Journal: Fed Proc Date: 1972 Nov-Dec

7. Physicochemical properties of the DNA of herpes viruses.

Authors: B J Graham; H Ludwig; D L Bronson; M Benyesh-Melnick; N Biswal
Journal: Biochim Biophys Acta Date: 1972-01-18

8. Potential mechanisms of action of antiviral agents.

Authors: W H Prusoff; B Goz
Journal: Fed Proc Date: 1973-06

9. Suppression of herpes simplex virus infection by phosphonoacetic acid.

Authors: N L Shipkowitz; R R Bower; R N Appell; C W Nordeen; L R Overby; W R Roderick; J B Schleicher; A M Von Esch
Journal: Appl Microbiol Date: 1973-09

10. Susceptibility of herpesviruses to cytosine arabinoside: standardization of susceptibility test procedure and relative resistance of herpes simplex type 2 strains.

Authors: M Fiala; A Chow; L B Guze
Journal: Antimicrob Agents Chemother Date: 1972-04 Impact factor: 5.191

61 in total

1. Regulation of herpesvirus macromolecular synthesis. VIII. The transcription program consists of three phases during which both extent of transcription and accumulation of RNA in the cytoplasm are regulated.

Authors: P C Jones; B Roizman
Journal: J Virol Date: 1979-08 Impact factor: 5.103

6. Activities of heterodimers composed of DNA-binding- and transactivation-deficient subunits of the herpes simplex virus regulatory protein ICP4.

Authors: A A Shepard; N A DeLuca
Journal: J Virol Date: 1991-01 Impact factor: 5.103

Inhibition of herpes simplex virus replication by phosphonoacetic acid.

1. Antibodies to Epstein-Barr virus in nasopharyngeal carcinoma, other head and neck neoplasms, and control groups.

2. THE MULTIPLICATION OF HERPES SIMPLEX VIRUS. I. THE PROGRAMMING OF VIRAL DNA DUPLICATION IN HEP-2 CELLS.

3. Role of herpesviruses in Marek's disease, a malignant lymphoma of chickens.

4. Herpesviruses saimiri and ateles--their role in malignant lymphomas of monkeys.

5. Possible role of Herpesvirus hominis, type 2, in human cervical cancer.

6. Role of herpesviruses in malignant lymphoma in rabbits.

7. Physicochemical properties of the DNA of herpes viruses.

8. Potential mechanisms of action of antiviral agents.

9. Suppression of herpes simplex virus infection by phosphonoacetic acid.

10. Susceptibility of herpesviruses to cytosine arabinoside: standardization of susceptibility test procedure and relative resistance of herpes simplex type 2 strains.

1. Regulation of herpesvirus macromolecular synthesis. VIII. The transcription program consists of three phases during which both extent of transcription and accumulation of RNA in the cytoplasm are regulated.

2. Inhibition of Epstein-Barr virus DNA synthesis and late gene expression by phosphonoacetic acid.

3. Efficacy of phosphonoacetic acid on herpes simplex virus infection of sensory ganglia.

4. Differential effect of phosphonoacetic acid on the expression of Epstein-Barr viral antigens and virus production.

5. Phosphonoacetic acid in the treatment of experimental ocular herpes simplex infections.

6. Activities of heterodimers composed of DNA-binding- and transactivation-deficient subunits of the herpes simplex virus regulatory protein ICP4.

7. Synthesis of proteins and glycoproteins in cells infected with human cytomegalovirus.

8. Deoxyribonucleic acid polymerase of wild-type and phosphonoacetic acid-resistant mutant of herpes simplex virus.

9. Requirement for cellular cyclin-dependent kinases in herpes simplex virus replication and transcription.

10. Effect of aphidicolin on vaccinia virus: isolation of an aphidicolin-resistant mutant.