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Literature DB >> 16789161

Inhibition of DNA polymerase from herpes simplex virus-infected wi-38 cells by phosphonoacetic Acid.

Abstract

Infection of Wi-38 cells with herpes simplex virus induced an elevated DNA polymerase activity which had many biochemical properties different from normal cell DNA polymerase. Phosphonoacetic acid specifically inhibited the virus-induced DNA polymerase as compared to the normal WI-38 cell DNA polymerase. The compound did not appear to inhibit enzyme activity by interacting with the DNA primer.

Entities: Chemical

Year: 1975 PMID： 16789161 PMCID： PMC354586

Source DB: PubMed Journal: J Virol ISSN： 0022-538X Impact factor: 5.103

10 in total

1. The structure of the DNA-acridine complex.

Authors: L S LERMAN
Journal: Proc Natl Acad Sci U S A Date: 1963-01-15 Impact factor: 11.205

2. Enzymatic synthesis of deoxyribonucleic acid. IX. The polymerase formed after T2 bacteriophage infection of Escherichia coli: a new enzyme.

Authors: H V APOSHIAN; A KORNBERG
Journal: J Biol Chem Date: 1962-02 Impact factor: 5.157

3. [On the mode of action of actinomycins].

Authors: H M RAUEN; H KERSTEN; W KERSTEN
Journal: Hoppe Seylers Z Physiol Chem Date: 1960-12-02

4. Inhibition of herpes simplex virus replication by phosphonoacetic acid.

Authors: L R Overby; E E Robishaw; J B Schleicher; A Rueter; N L Shipkowitz; J C Mao
Journal: Antimicrob Agents Chemother Date: 1974-09 Impact factor: 5.191

5. Characterization of herpes simplex virus-induced deoxyribonucleic acid polymerase.

Authors: A Weissbach; S C Hong; J Aucker; R Muller
Journal: J Biol Chem Date: 1973-09-25 Impact factor: 5.157

6. DNA-dependent DNA polymerases I and II from normal human-blood lymphocytes.

Authors: R G Smith; R C Gallo
Journal: Proc Natl Acad Sci U S A Date: 1972-10 Impact factor: 11.205

7. DNA polymerases in human lymphoblastoid cells infected with simian sarcoma virus.

Authors: B J Lewis; J W Abrell; R G Smith; R C Gallo
Journal: Biochim Biophys Acta Date: 1974-05-17

8. Altered properties of deoxyribonucleic acid nucleotidyltransferase after infection of mammalian cells with herpes simplex virus.

Authors: H M Keir; J Hay; J M Morrison; H Subak-Sharpe
Journal: Nature Date: 1966-04-23 Impact factor: 49.962

9. Base specificity in the interaction of polynucleotides with antibiotic drugs.

Authors: D C Ward; E Reich; I H Goldberg
Journal: Science Date: 1965-09-10 Impact factor: 47.728

10. Suppression of herpes simplex virus infection by phosphonoacetic acid.

Authors: N L Shipkowitz; R R Bower; R N Appell; C W Nordeen; L R Overby; W R Roderick; J B Schleicher; A M Von Esch
Journal: Appl Microbiol Date: 1973-09

10 in total

66 in total

1. Conformational changes in the herpes simplex virus ICP8 DNA-binding protein coincident with assembly in viral replication structures.

Authors: Susan L Uprichard; David M Knipe
Journal: J Virol Date: 2003-07 Impact factor: 5.103

2. Structure and origin of defective genomes contained in serially passaged herpes simplex virus type 1 (Justin).

Authors: H Locker; N Frenkel
Journal: J Virol Date: 1979-03 Impact factor: 5.103

3. Regulation of herpesvirus macromolecular synthesis. VIII. The transcription program consists of three phases during which both extent of transcription and accumulation of RNA in the cytoplasm are regulated.

Authors: P C Jones; B Roizman
Journal: J Virol Date: 1979-08 Impact factor: 5.103

Inhibition of DNA polymerase from herpes simplex virus-infected wi-38 cells by phosphonoacetic Acid.

1. The structure of the DNA-acridine complex.

2. Enzymatic synthesis of deoxyribonucleic acid. IX. The polymerase formed after T2 bacteriophage infection of Escherichia coli: a new enzyme.

3. [On the mode of action of actinomycins].

4. Inhibition of herpes simplex virus replication by phosphonoacetic acid.

5. Characterization of herpes simplex virus-induced deoxyribonucleic acid polymerase.

6. DNA-dependent DNA polymerases I and II from normal human-blood lymphocytes.

7. DNA polymerases in human lymphoblastoid cells infected with simian sarcoma virus.

8. Altered properties of deoxyribonucleic acid nucleotidyltransferase after infection of mammalian cells with herpes simplex virus.

9. Base specificity in the interaction of polynucleotides with antibiotic drugs.

10. Suppression of herpes simplex virus infection by phosphonoacetic acid.

1. Conformational changes in the herpes simplex virus ICP8 DNA-binding protein coincident with assembly in viral replication structures.

2. Structure and origin of defective genomes contained in serially passaged herpes simplex virus type 1 (Justin).

3. Regulation of herpesvirus macromolecular synthesis. VIII. The transcription program consists of three phases during which both extent of transcription and accumulation of RNA in the cytoplasm are regulated.

4. Inhibition of Epstein-Barr virus DNA synthesis and late gene expression by phosphonoacetic acid.

5. Efficacy of phosphonoacetic acid on herpes simplex virus infection of sensory ganglia.

6. Differential effect of phosphonoacetic acid on the expression of Epstein-Barr viral antigens and virus production.

7. Phosphonoacetic acid in the treatment of experimental ocular herpes simplex infections.

8. Synthesis of proteins and glycoproteins in cells infected with human cytomegalovirus.

9. Deoxyribonucleic acid polymerase of wild-type and phosphonoacetic acid-resistant mutant of herpes simplex virus.

10. Cytofluorometry of lymphocytes infected with Epstein-Barr virus: effect of phosphonoacetic acid on nucleic acid.