Literature DB >> 7334384

Anticancer indole alkaloids of Rhazya stricta.

S Mukhopadhyay, G A Handy, S Funayama, G A Cordell.   

Abstract

The leaves and roots of Rhazya stricta (Apocynaceae) yielded four indole alkaloids. Three of these isolated, vallesiachotamine (1), sewarine (3) and tetrahydrosecamine (4), displayed cytotoxic activity; polyneuridine (2) was not reported previously from this species. Tetrahydrosecaminediol (5), its acetate 6, and didemethoxycarbonyl-tetrahydrosecamine (7) were prepared from tetrahydrosecamine (4) by chemical reactions. The diol 5 was highly cytotoxic.

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Year:  1981        PMID： 7334384     DOI： 10.1021/np50018a014

Source DB:  PubMed          Journal:  J Nat Prod        ISSN： 0163-3864            Impact factor:   4.050


  20 in total

1.  Crystal structure of 3'-(1H-indole-3-carbon-yl)-1'-methyl-2-oxo-4'-(4-oxo-4H-chromen-3-yl)spiro-[indoline-3,2'-pyrrolidine]-3'-carbo-nitrile.

Authors:  M P Savithri; R Raja; D Kathirvelan; B S R Reddy; A SubbiahPandi
Journal:  Acta Crystallogr E Crystallogr Commun       Date:  2015-10-31

2.  Cheminformatics studies to analyze the therapeutic potential of phytochemicals from Rhazya stricta.

Authors:  Abdullah Y Obaid; Sreedhara Voleti; Roop Singh Bora; Nahid H Hajrah; Abdulkader M Shaikh Omer; Jamal S M Sabir; Kulvinder Singh Saini
Journal:  Chem Cent J       Date:  2017-01-30       Impact factor: 4.215

3.  Ethyl 2-acetoxy-methyl-1-phenyl-sulfonyl-1H-indole-3-carboxyl-ate.

Authors:  B Gunasekaran; Radhakrishnan Sureshbabu; A K Mohanakrishnan; G Chakkaravarthi; V Manivannan
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2009-08-08

4.  Methyl 2-(5-chloro-1-methyl-2-oxo-2,3-di-hydro-1H-indol-3-ylidene)acetate.

Authors:  Piskala Subburaman Kannan; Panneerselvam Yuvaraj; Karthikeyan Manivannan; Boreddy S R Reddy; A Subbiahpandi
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2013-05-11

5.  N-[(3-Phenylsulfanyl-1-phenylsulfonyl-1H-indol-2-yl)methyl]acetamide.

Authors:  S Thenmozhi; A Subbiahpandi; V Dhayalan; A K Mohanakrishnan
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2009-04-10

6.  (3-Phenyl-sulfanyl-1-phenyl-sulfonyl-1H-indol-2-yl)methyl acetate.

Authors:  Alagappa Rammohan; E Govindan; A Subbiahpandi; R Sureshbabu; A K Mohana Krishnan
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2011-04-29

7.  Crystal structure of ethyl 1',5-dimethyl-2'',3-dioxo-3H-di-spiro-[benzo[b]thiophene-2,3'-pyrrolidine-2',3''-indoline]-4'-carboxyl-ate.

Authors:  R Raja; J Govindaraj; M Suresh; R Raghunathan; A SubbiahPandi
Journal:  Acta Crystallogr E Crystallogr Commun       Date:  2015-02-07

8.  1-[6-(1H-Indol-1-yl)pyridin-2-yl]-1H-indole-3-carbaldehyde.

Authors:  C Ramathilagam; P R Umarani; N Venkatesan; P Rajakumar; B Gunasekaran; V Manivannan
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2014-01-04

9.  (E)-1-[2-(2-Nitro-styr-yl)-1-phenyl-sulfonyl-1H-indol-3-yl]propan-1-one.

Authors:  J Kanchanadevi; G Anbalagan; V Saravanan; A K Mohanakrishnan; B Gunasekaran; V Manivannan
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2014-01-15

10.  Crude alkaloid extract of Rhazya stricta inhibits cell growth and sensitizes human lung cancer cells to cisplatin through induction of apoptosis.

Authors:  Ayman I Elkady
Journal:  Genet Mol Biol       Date:  2013-03-04       Impact factor: 1.771
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