| Literature DB >> 25224663 |
Yan-Jiun Lee1, Yadagiri Kurra, Yanyan Yang, Jessica Torres-Kolbus, Alexander Deiters, Wenshe R Liu.
Abstract
A number of non-canonical amino acids (NCAAs) with unstrained olefins are genetically encoded using mutant pyrrolysyl-tRNA synthetase-tRNA(Pyl)(CUA) pairs. These NCAAs readily undergo inverse electron-demand Diels-Alder cycloadditions with tetrazine dyes, leading to selective labeling of proteins bearing these NCAAs in live cells.Entities:
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Year: 2014 PMID: 25224663 PMCID: PMC4184966 DOI: 10.1039/c4cc06435f
Source DB: PubMed Journal: Chem Commun (Camb) ISSN: 1359-7345 Impact factor: 6.222