OBJECTIVE: The purpose of this study was to prospectively evaluate the contrast enhancement, vascular depiction, image quality, and radiation dose of low-tube-voltage whole-body CT angiography (CTA) performed with low-concentration iodinated contrast material. SUBJECTS AND METHODS: Whole-body CTA was performed on 109 patients with a 64-MDCT scanner. Patients were randomized into three groups: CTA with 240-mg/mL contrast material at 80 kVp (240-80 group), 300-mg/mL at 80 kVp (300-80 group), and 370-mg/mL at 120 kVp (370-120 group). Signal-to-noise ratio (SNR), arterial depiction, image quality, and radiation dose were assessed. Figure of merit was computed to normalize signal-to-noise ratio, estimated effective dose, and iodine weight. RESULTS: In the 240-80 group, the mean load of administered iodine was 21.6 g; for the 300-80 group, 26.8 g; and the 370-120 group, 34.0 g (p < 0.05). The ranges of mean vascular enhancement were 508-521 HU, 546-593 HU, and 435-442 HU (p < 0.05). Arterial depiction and image quality were comparable for the 240-80 and 370-120 groups and were greater for the 300-80 group than the other two groups in selected arteries (p < 0.05). Effective dose was higher (p < 0.05) in the 370-120 group (2.8-5.4 mSv) than in the others (2.3-4.3 mSv). The figure of merit in the 240-80 group was greater than (p < 0.05) or comparable to that in the 370-120 group. CONCLUSION: Use of 240-mg/mL contrast material at 80 kVp seems appropriate for routine whole-body CTA and beneficial for reduction of iodine load and radiation dose, whereas use of 300-mg/mL contrast material may marginally improve delineation of selected small arteries.
RCT Entities:
OBJECTIVE: The purpose of this study was to prospectively evaluate the contrast enhancement, vascular depiction, image quality, and radiation dose of low-tube-voltage whole-body CT angiography (CTA) performed with low-concentration iodinated contrast material. SUBJECTS AND METHODS: Whole-body CTA was performed on 109 patients with a 64-MDCT scanner. Patients were randomized into three groups: CTA with 240-mg/mL contrast material at 80 kVp (240-80 group), 300-mg/mL at 80 kVp (300-80 group), and 370-mg/mL at 120 kVp (370-120 group). Signal-to-noise ratio (SNR), arterial depiction, image quality, and radiation dose were assessed. Figure of merit was computed to normalize signal-to-noise ratio, estimated effective dose, and iodine weight. RESULTS: In the 240-80 group, the mean load of administered iodine was 21.6 g; for the 300-80 group, 26.8 g; and the 370-120 group, 34.0 g (p < 0.05). The ranges of mean vascular enhancement were 508-521 HU, 546-593 HU, and 435-442 HU (p < 0.05). Arterial depiction and image quality were comparable for the 240-80 and 370-120 groups and were greater for the 300-80 group than the other two groups in selected arteries (p < 0.05). Effective dose was higher (p < 0.05) in the 370-120 group (2.8-5.4 mSv) than in the others (2.3-4.3 mSv). The figure of merit in the 240-80 group was greater than (p < 0.05) or comparable to that in the 370-120 group. CONCLUSION: Use of 240-mg/mL contrast material at 80 kVp seems appropriate for routine whole-body CTA and beneficial for reduction of iodine load and radiation dose, whereas use of 300-mg/mL contrast material may marginally improve delineation of selected small arteries.
Authors: Jan-Erik Scholtz; Moritz Kaup; Johannes Kraft; Eva-Maria Nöske; Friedrich Scheerer; Boris Schulz; Iris Burck; Jens Wagenblast; J Matthias Kerl; Ralf W Bauer; Thomas Lehnert; Thomas J Vogl; Julian L Wichmann Journal: Neuroradiology Date: 2015-03-26 Impact factor: 2.804
Authors: Douglas H Sheafor; Mark D Kovacs; Philip Burchett; Melissa M Picard; Brenton Davis; Andrew D Hardie Journal: Radiol Med Date: 2018-08-06 Impact factor: 3.469
Authors: Michael M Lell; Ulrike Fleischmann; Hubertus Pietsch; Johannes G Korporaal; Ulrike Haberland; Andreas H Mahnken; Thomas G Flohr; Michael Uder; Gregor Jost Journal: PLoS One Date: 2017-03-20 Impact factor: 3.240