Literature DB >> 21119228

Tapered LSO arrays for small animal PET.

Yongfeng Yang1, Sara St James, Yibao Wu, Huini Du, Jinyi Qi, Richard Farrell, Purushottam A Dokhale, Kanai S Shah, Keith Vaigneur, Simon R Cherry.   

Abstract

By using detectors with good depth encoding accuracy (∼2 mm), an animal PET scanner can be built with a small ring diameter and thick crystals to simultaneously obtain high spatial resolution and high sensitivity. However, there will be large wedge-shaped gaps between detector modules in such a scanner if traditional cuboid crystal arrays are used in a polygonal arrangement. The gaps can be minimized by using tapered scintillator arrays enabling the sensitivity of the scanner to be further improved. In this work, tapered lutetium oxyorthosilicate (LSO) arrays with different crystal dimensions and different combinations of inter-crystal reflector and crystal surface treatments were manufactured and their performance was evaluated. Arrays were read out from both ends by position-sensitive avalanche photodiodes (PSAPDs). In the optimal configuration, arrays consisting of 0.5 mm LSO elements could be clearly resolved and a depth of interaction resolution of 2.6 mm was obtained for a 20 mm thick array. For this tapered array, the intrinsic spatial is degraded from 0.67 to 0.75 mm compared to a standard cuboidal array with similar dimensions, while the increase in efficiency is 41%. Tapered scintillator arrays offer the prospect of improvements in sensitivity and sampling for small-bore scanners, without large increases in manufacturing complexity.

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Year:  2010        PMID: 21119228      PMCID: PMC3117425          DOI: 10.1088/0031-9155/56/1/009

Source DB:  PubMed          Journal:  Phys Med Biol        ISSN: 0031-9155            Impact factor:   3.609


  23 in total

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Journal:  Phys Med Biol       Date:  2004-02-07       Impact factor: 3.609

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Authors:  Yuan-Chuan Tai; Ananya Ruangma; Douglas Rowland; Stefan Siegel; Danny F Newport; Patrick L Chow; Richard Laforest
Journal:  J Nucl Med       Date:  2005-03       Impact factor: 10.057

3.  Evaluation of high performance data acquisition boards for simultaneous sampling of fast signals from PET detectors.

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Journal:  Phys Med Biol       Date:  2005-01-07       Impact factor: 3.609

4.  Performance measurements of a depth-encoding PET detector module based on position-sensitive avalanche photodiode read-out.

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Journal:  Phys Med Biol       Date:  2004-09-21       Impact factor: 3.609

Review 5.  Positron emission tomography.

Authors:  Gerd Muehllehner; Joel S Karp
Journal:  Phys Med Biol       Date:  2006-06-20       Impact factor: 3.609

6.  Depth of interaction resolution measurements for a high resolution PET detector using position sensitive avalanche photodiodes.

Authors:  Yongfeng Yang; Purushottam A Dokhale; Robert W Silverman; Kanai S Shah; Mickel A McClish; Richard Farrell; Gerald Entine; Simon R Cherry
Journal:  Phys Med Biol       Date:  2006-04-10       Impact factor: 3.609

Review 7.  The 2006 Henry N. Wagner Lecture: Of mice and men (and positrons)--advances in PET imaging technology.

Authors:  Simon R Cherry
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9.  Performance evaluation of the GE healthcare eXplore VISTA dual-ring small-animal PET scanner.

Authors:  Yuchuan Wang; Jurgen Seidel; Benjamin M W Tsui; Juan J Vaquero; Martin G Pomper
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Authors:  Yongfeng Yang; Yuan-Chuan Tai; Stefan Siegel; Danny F Newport; Bing Bai; Quanzheng Li; Richard M Leahy; Simon R Cherry
Journal:  Phys Med Biol       Date:  2004-06-21       Impact factor: 3.609

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  14 in total

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2.  Effects of reflector and crystal surface on the performance of a depth-encoding PET detector with dual-ended readout.

Authors:  Silin Ren; Yongfeng Yang; Simon R Cherry
Journal:  Med Phys       Date:  2014-07       Impact factor: 4.071

3.  Model-Based Normalization of a Fractional-Crystal Collimator for Small-Animal PET Imaging.

Authors:  Yusheng Li; Samuel Matej; Joel S Karp; Scott D Metzler
Journal:  IEEE Trans Radiat Plasma Med Sci       Date:  2017-03-15

4.  A Prototype High-Resolution Small-Animal PET Scanner Dedicated to Mouse Brain Imaging.

Authors:  Yongfeng Yang; Julien Bec; Jian Zhou; Mengxi Zhang; Martin S Judenhofer; Xiaowei Bai; Kun Di; Yibao Wu; Mercedes Rodriguez; Purushottam Dokhale; Kanai S Shah; Richard Farrell; Jinyi Qi; Simon R Cherry
Journal:  J Nucl Med       Date:  2016-03-24       Impact factor: 10.057

5.  Performance of a high-resolution depth-encoding PET detector module using linearly-graded SiPM arrays.

Authors:  Junwei Du; Xiaowei Bai; Alberto Gola; Fabio Acerbi; Alessandro Ferri; Claudio Piemonte; Yongfeng Yang; Simon R Cherry
Journal:  Phys Med Biol       Date:  2018-02-05       Impact factor: 3.609

6.  Optimization of a depth of interaction encoding PET block detector for a PET/MRI insert.

Authors:  Aaron R Selfridge; Simon R Cherry; Martin S Judenhofer
Journal:  Phys Med Biol       Date:  2018-12-06       Impact factor: 3.609

7.  LOR-interleaving image reconstruction for PET imaging with fractional-crystal collimation.

Authors:  Yusheng Li; Samuel Matej; Joel S Karp; Scott D Metzler
Journal:  Phys Med Biol       Date:  2015-01-02       Impact factor: 3.609

Review 8.  Positron Emission Tomography: Current Challenges and Opportunities for Technological Advances in Clinical and Preclinical Imaging Systems.

Authors:  Juan José Vaquero; Paul Kinahan
Journal:  Annu Rev Biomed Eng       Date:  2015       Impact factor: 9.590

9.  A Monte Carlo investigation of the spatial resolution performance of a small-animal PET scanner designed for mouse brain imaging studies.

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10.  Characterization of a high-resolution hybrid DOI detector for a dedicated breast PET/CT scanner.

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Journal:  Phys Med Biol       Date:  2012-05-11       Impact factor: 3.609

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