Literature DB >> 19953123

Non-invasive prenatal testing: ethical issues explored.

Antina de Jong1, Wybo J Dondorp, Christine E M de Die-Smulders, Suzanne G M Frints, Guido M W R de Wert.   

Abstract

This paper explores the ethical implications of introducing non-invasive prenatal diagnostic tests (NIPD tests) in prenatal screening for foetal abnormalities. NIPD tests are easy and safe and can be performed early in pregnancy. Precisely because of these features, it is feared that informed consent may become more difficult, that both testing and selective abortion will become 'normalized', and that there will be a trend towards accepting testing for minor abnormalities and non-medical traits as well. In our view, however, the real moral challenge of NIPD testing consists in the possibility of linking up a technique with these features (easy, safe and early) with new genomic technologies that allow prenatal diagnostic testing for a much broader range of abnormalities than is the case in current procedures. An increase in uptake and more selective abortions need not in itself be taken to signal a thoughtless acceptance of these procedures. However, combining this with considerably enlarging the scope of NIPD testing will indeed make informed consent more difficult and challenge the notion of prenatal screening as serving reproductive autonomy. If broad NIPD testing includes later-onset diseases, the 'right not to know' of the future child will become a new issue in the debate about prenatal screening. With regard to the controversial issue of selective abortion, it may make a morally relevant difference that after NIPD testing, abortion can be done early. A lower moral status may be attributed to the foetus at that moment, given the dominant opinion that the moral status of the foetus progressively increases with its development.

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Year:  2009        PMID: 19953123      PMCID: PMC2987207          DOI: 10.1038/ejhg.2009.203

Source DB:  PubMed          Journal:  Eur J Hum Genet        ISSN: 1018-4813            Impact factor:   4.246


  44 in total

Review 1.  [Rapid prenatal diagnosis of chromosomal abnormalities; limitations and possibilities].

Authors:  L P ten Kate
Journal:  Ned Tijdschr Geneeskd       Date:  2006-07-22

Review 2.  The obstetrician's view: ethical and societal implications of non-invasive prenatal diagnosis.

Authors:  Richard P Smith; Hennie Lombaard; Peter W Soothill
Journal:  Prenat Diagn       Date:  2006-07       Impact factor: 3.050

3.  At-home fetal DNA gender testing: caveat emptor.

Authors:  Diana W Bianchi
Journal:  Obstet Gynecol       Date:  2006-02       Impact factor: 7.661

4.  Generic consent for genetic screening.

Authors:  S Elias; G J Annas
Journal:  N Engl J Med       Date:  1994-06-02       Impact factor: 91.245

Review 5.  Attitudes towards sex selection for non-medical reasons: a review.

Authors:  Sue Hall; Erin Reid; Theresa M Marteau
Journal:  Prenat Diagn       Date:  2006-07       Impact factor: 3.050

6.  Fetal anomaly screening: what do women want to know?

Authors:  Joan Lalor; Cecily Begley
Journal:  J Adv Nurs       Date:  2006-07       Impact factor: 3.187

Review 7.  Comparative genomic hybridization and prenatal diagnosis.

Authors:  Ignatia B Van den Veyver; Arthur L Beaudet
Journal:  Curr Opin Obstet Gynecol       Date:  2006-04       Impact factor: 1.927

8.  Feminist discourse on sex screening and selective abortion of female foetuses.

Authors:  Farhat Moazam
Journal:  Bioethics       Date:  2004-06       Impact factor: 1.898

9.  How can the evaluation of genetic tests be enhanced? Lessons learned from the ACCE framework and evaluating genetic tests in the United Kingdom.

Authors:  Simon Sanderson; Ron Zimmern; Mark Kroese; Julian Higgins; Christine Patch; Jon Emery
Journal:  Genet Med       Date:  2005-09       Impact factor: 8.822

10.  What is the clinical utility of genetic testing?

Authors:  Scott D Grosse; Muin J Khoury
Journal:  Genet Med       Date:  2006-07       Impact factor: 8.822

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  47 in total

1.  A new era in prenatal testing: are we prepared?

Authors:  Dagmar Schmitz
Journal:  Med Health Care Philos       Date:  2013-08

2.  Points to consider in assessing and appraising predictive genetic tests.

Authors:  Wolf H Rogowski; Scott D Grosse; Jürgen John; Helena Kääriäinen; Alastair Kent; Ulf Kristofferson; Jörg Schmidtke
Journal:  J Community Genet       Date:  2010-10-16

3.  Whole-genome sequencing in health care. Recommendations of the European Society of Human Genetics.

Authors:  Carla G van El; Martina C Cornel; Pascal Borry; Ros J Hastings; Florence Fellmann; Shirley V Hodgson; Heidi C Howard; Anne Cambon-Thomsen; Bartha M Knoppers; Hanne Meijers-Heijboer; Hans Scheffer; Lisbeth Tranebjaerg; Wybo Dondorp; Guido M W R de Wert
Journal:  Eur J Hum Genet       Date:  2013-06       Impact factor: 4.246

4.  "Don't Want No Risk and Don't Want No Problems": Public Understandings of the Risks and Benefits of Non-Invasive Prenatal Testing in the United States.

Authors:  Megan Allyse; Lauren Carter Sayres; Taylor Goodspeed; Marsha Michie; Mildred K Cho
Journal:  AJOB Empir Bioeth       Date:  2015

5.  Rapid aneuploidy detection or karyotyping? Ethical reflection.

Authors:  Antina de Jong; Wybo J Dondorp; Daniëlle R M Timmermans; Jan M M van Lith; Guido M W R de Wert
Journal:  Eur J Hum Genet       Date:  2011-06-01       Impact factor: 4.246

Review 6.  Advances in prenatal screening: the ethical dimension.

Authors:  Antina de Jong; Wybo J Dondorp; Suzanna G M Frints; Christine E M de Die-Smulders; Guido M W R de Wert
Journal:  Nat Rev Genet       Date:  2011-08-18       Impact factor: 53.242

7.  Patients' Knowledge of Prenatal Screening for Trisomy 21.

Authors:  Michal Sheinis; Kira Bensimon; Amanda Selk
Journal:  J Genet Couns       Date:  2017-07-14       Impact factor: 2.537

8.  Cell-free fetal DNA testing for fetal aneuploidy and beyond: clinical integration challenges in the US context.

Authors:  Megan Allyse; Lauren C Sayres; Jaime S King; Mary E Norton; Mildred K Cho
Journal:  Hum Reprod       Date:  2012-08-03       Impact factor: 6.918

Review 9.  Cell-Free DNA Screening: Complexities and Challenges of Clinical Implementation.

Authors:  Matthew R Grace; Emily Hardisty; Sarah K Dotters-Katz; Neeta L Vora; Jeffrey A Kuller
Journal:  Obstet Gynecol Surv       Date:  2016-08       Impact factor: 2.347

10.  Best ethical practices for clinicians and laboratories in the provision of noninvasive prenatal testing.

Authors:  M A Allyse; L C Sayres; M Havard; J S King; H T Greely; L Hudgins; J Taylor; M E Norton; M K Cho; D Magnus; K E Ormond
Journal:  Prenat Diagn       Date:  2013-05-21       Impact factor: 3.050

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