Literature DB >> 22477039

A new era in prenatal testing: are we prepared?

Dagmar Schmitz1.   

Abstract

Prenatal care and the practice of prenatal genetic testing are about to be changed fundamentally. Due to several ground-breaking technological developments prenatal screening and diagnosis (PND) will soon be offered earlier in gestation, with less procedure-related risks and for a profoundly enlarged variety of targets. In this paper it is argued that the existing normative framework for prenatal screening and diagnosis cannot answer adequately to these new developments. In concentrating on issues of informed consent and the reproductive autonomy of the pregnant women the ethical debate misses problems related to the clinical pathway as a whole and to implicit normative attributions to clinical actions or the function of health care professionals. If, however, ethical debate would focus on the clinical context and on the ends of PND to a larger extent, it would be able to provide a more comprehensive analysis of the ethical challenges especially of the new technologies in order to be more adequately prepared for their implementation.

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Year:  2013        PMID: 22477039     DOI: 10.1007/s11019-012-9411-y

Source DB:  PubMed          Journal:  Med Health Care Philos        ISSN: 1386-7423


  20 in total

1.  Medicine as techne--a perspective from antiquity.

Authors:  Bjørn Hofmann
Journal:  J Med Philos       Date:  2003-08

2.  Maternal plasma DNA sequencing reveals the genome-wide genetic and mutational profile of the fetus.

Authors:  Y M Dennis Lo; K C Allen Chan; Hao Sun; Eric Z Chen; Peiyong Jiang; Fiona M F Lun; Yama W Zheng; Tak Y Leung; Tze K Lau; Charles R Cantor; Rossa W K Chiu
Journal:  Sci Transl Med       Date:  2010-12-08       Impact factor: 17.956

3.  Plasma placental RNA allelic ratio permits noninvasive prenatal chromosomal aneuploidy detection.

Authors:  Y M Dennis Lo; Nancy B Y Tsui; Rossa W K Chiu; Tze K Lau; Tse N Leung; Macy M S Heung; Ageliki Gerovassili; Yongjie Jin; Kypros H Nicolaides; Charles R Cantor; Chunming Ding
Journal:  Nat Med       Date:  2007-01-07       Impact factor: 53.440

Review 4.  SAFE--the Special Non-invasive Advances in Fetal and Neonatal Evaluation Network: aims and achievements.

Authors:  Lyn S Chitty; C Ellen van der Schoot; Sinuhe Hahn; Neil D Avent
Journal:  Prenat Diagn       Date:  2008-02       Impact factor: 3.050

5.  Non-invasive prenatal testing: ethical issues explored.

Authors:  Antina de Jong; Wybo J Dondorp; Christine E M de Die-Smulders; Suzanne G M Frints; Guido M W R de Wert
Journal:  Eur J Hum Genet       Date:  2009-12-02       Impact factor: 4.246

6.  Non-invasive prenatal diagnosis for aneuploidy: toward an integral ethical assessment.

Authors:  Antina de Jong; Wybo J Dondorp; Suzanna G M Frints; Christine E M de Die-Smulders; Guido M W R de Wert
Journal:  Hum Reprod       Date:  2011-08-12       Impact factor: 6.918

Review 7.  Prenatal diagnosis of genetic disorders: trials and tribulations.

Authors:  R G Davidson; M C Rattazzi
Journal:  Clin Chem       Date:  1972-03       Impact factor: 8.327

8.  Non-invasive prenatal assessment of trisomy 21 by multiplexed maternal plasma DNA sequencing: large scale validity study.

Authors:  Rossa W K Chiu; Ranjit Akolekar; Yama W L Zheng; Tak Y Leung; Hao Sun; K C Allen Chan; Fiona M F Lun; Attie T J I Go; Elizabeth T Lau; William W K To; Wing C Leung; Rebecca Y K Tang; Sidney K C Au-Yeung; Helena Lam; Yu Y Kung; Xiuqing Zhang; John M G van Vugt; Ryoko Minekawa; Mary H Y Tang; Jun Wang; Cees B M Oudejans; Tze K Lau; Kypros H Nicolaides; Y M Dennis Lo
Journal:  BMJ       Date:  2011-01-11

9.  Some limits of informed consent.

Authors:  O O'Neill
Journal:  J Med Ethics       Date:  2003-02       Impact factor: 2.903

10.  What is the clinical utility of genetic testing?

Authors:  Scott D Grosse; Muin J Khoury
Journal:  Genet Med       Date:  2006-07       Impact factor: 8.822

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  2 in total

1.  On prenatal diagnosis and the decision to continue or terminate a pregnancy in France: a clinical ethics study of unknown moral territories.

Authors:  Marie Gaille
Journal:  Med Health Care Philos       Date:  2016-09

2.  The fetus in the age of the genome.

Authors:  Dagmar Schmitz; Wolfram Henn
Journal:  Hum Genet       Date:  2021-08-23       Impact factor: 5.881

  2 in total

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