Literature DB >> 1833548

Linkage disequilibrium and recombination make a telomeric site for the Huntington's disease gene unlikely.

L Barron1, A Curtis, A E Shrimpton, S Holloway, H May, R G Snell, D J Brock.   

Abstract

In a Scottish family in which Huntington's disease (HD) was segregating, recombination was observed between the D4S115/S111 and D4S43/S95 loci, with the HD gene associated with the more proximal D4S43/S95 locus. Analysis of linkage disequilibrium in Scottish families showed significant non-random association between the HD gene and alleles at the D4S95 and D4S98 loci. This adds to previous evidence that the HD locus is not sited at the telomere of chromosome 4.

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Year:  1991        PMID： 1833548      PMCID： PMC1016979          DOI： 10.1136/jmg.28.8.520

Source DB:  PubMed          Journal:  J Med Genet        ISSN： 0022-2593            Impact factor:   6.318


  12 in total

1.  A new DNA marker (D4S90) is located terminally on the short arm of chromosome 4, close to the Huntington disease gene.

Authors:  S Youngman; M Sarfarazi; M Bucan; M MacDonald; B Smith; M Zimmer; C Gilliam; A M Frischauf; J J Wasmuth; J F Gusella
Journal:  Genomics       Date:  1989-11       Impact factor: 5.736

2.  Mapping of D4S98/S114/S113 confines the Huntington's defect to a reduced physical region at the telomere of chromosome 4.

Authors:  W L Whaley; F Michiels; M E MacDonald; D Romano; M Zimmer; B Smith; J Leavitt; M Bucan; J L Haines; T C Gilliam
Journal:  Nucleic Acids Res       Date:  1988-12-23       Impact factor: 16.971

3.  A polymorphic DNA marker genetically linked to Huntington's disease.

Authors:  J F Gusella; N S Wexler; P M Conneally; S L Naylor; M A Anderson; R E Tanzi; P C Watkins; K Ottina; M R Wallace; A Y Sakaguchi
Journal:  Nature       Date:  1983 Nov 17-23       Impact factor: 49.962

4.  Non-random association between alleles detected at D4S95 and D4S98 and the Huntington's disease gene.

Authors:  J Theilmann; S Kanani; R Shiang; C Robbins; O Quarrell; M Huggins; A Hedrick; B Weber; C Collins; J J Wasmuth
Journal:  J Med Genet       Date:  1989-11       Impact factor: 6.318

5.  Linkage disequilibrium in Huntington's disease: an improved localisation for the gene.

Authors:  R G Snell; L P Lazarou; S Youngman; O W Quarrell; J J Wasmuth; D J Shaw; P S Harper
Journal:  J Med Genet       Date:  1989-11       Impact factor: 6.318

6.  A yeast artificial chromosome telomere clone spanning a possible location of the Huntington disease gene.

Authors:  G P Bates; M E MacDonald; S Baxendale; Z Sedlacek; S Youngman; D Romano; W L Whaley; B A Allitto; A Poustka; J F Gusella
Journal:  Am J Hum Genet       Date:  1990-04       Impact factor: 11.025

7.  Clustering of multiallele DNA markers near the Huntington's disease gene.

Authors:  M E MacDonald; S V Cheng; M Zimmer; J L Haines; A Poustka; B Allitto; B Smith; W L Whaley; D M Romano; J Jagadeesh
Journal:  J Clin Invest       Date:  1989-09       Impact factor: 14.808

8.  A cloned DNA segment from the telomeric region of human chromosome 4p is not detectably rearranged in Huntington disease patients.

Authors:  C Pritchard; D Casher; L Bull; D R Cox; R M Myers
Journal:  Proc Natl Acad Sci U S A       Date:  1990-09       Impact factor: 11.205

9.  The Huntington disease locus is most likely within 325 kilobases of the chromosome 4p telomere.

Authors:  N A Doggett; J F Cheng; C L Smith; C R Cantor
Journal:  Proc Natl Acad Sci U S A       Date:  1989-12       Impact factor: 11.205

10.  A highly polymorphic locus very tightly linked to the Huntington's disease gene.

Authors:  J J Wasmuth; J Hewitt; B Smith; D Allard; J L Haines; D Skarecky; E Partlow; M R Hayden
Journal:  Nature       Date:  1988-04-21       Impact factor: 49.962
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  5 in total

1.  Recombination of 4p16 DNA markers in an unusual family with Huntington disease.

Authors:  C Pritchard; N Zhu; J Zuo; L Bull; M A Pericak-Vance; J M Vance; A D Roses; A Milatovich; U Francke; D R Cox
Journal:  Am J Hum Genet       Date:  1992-06       Impact factor: 11.025

2.  A recombination event that redefines the Huntington disease region.

Authors:  R G Snell; L M Thompson; D A Tagle; T L Holloway; G Barnes; H G Harley; L A Sandkuijl; M E MacDonald; F S Collins; J F Gusella
Journal:  Am J Hum Genet       Date:  1992-08       Impact factor: 11.025

3.  Significant linkage disequilibrium between the Huntington's disease locus and markers at loci D4S10, D4S95, and D4S111 in Northern Ireland.

Authors:  P J Morrison; C A Graham; N C Nevin
Journal:  J Med Genet       Date:  1993-12       Impact factor: 6.318

4.  Significant linkage disequilibrium between the Huntington disease gene and the loci D4S10 and D4S95 in the Dutch population.

Authors:  M I Skraastad; E Van de Vosse; R Belfroid; K Höld; M Vegter-van der Vlis; L A Sandkuijl; E Bakker; G J van Ommen
Journal:  Am J Hum Genet       Date:  1992-10       Impact factor: 11.025

5.  Allele frequencies and linkage disequilibrium of polymorphic DNA markers of the Huntington disease region in the German population.

Authors:  U Thies; B Bockel; B Gerdes; K Schröder
Journal:  Hum Genet       Date:  1993-12       Impact factor: 4.132
  5 in total

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