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Literature DB >> 7903271

Allele frequencies and linkage disequilibrium of polymorphic DNA markers of the Huntington disease region in the German population.

U Thies¹, B Bockel, B Gerdes, K Schröder.

Abstract

Allele frequencies of 14 different restriction fragment length polymorphisms from 12 DNA markers within the Huntington disease (HD) region were evaluated in the German population. No significant differences from published data of allele frequencies from chromosomes of Caucasian ancestry were found. The analysis of eight DNA polymorphisms in 87 HD families of German origin revealed significant non-random association with the HD locus and the D4S95 locus (p674/AccI/MboI), a result that is consistent with all other published studies. These results are confirmed by the fact that the HD gene maps to this region.

Entities: Disease

Mesh：

Substances：
Genetic Markers
DNA

Year: 1993 PMID： 7903271 DOI： 10.1007/bf00420945

Source DB: PubMed Journal: Hum Genet ISSN： 0340-6717 Impact factor: 4.132

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References

27 in total

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Journal: Nucleic Acids Res Date: 1991-11-25 Impact factor: 16.971

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Journal: Genomics Date: 1989-11 Impact factor: 5.736

10. Huntington disease in Finland: linkage disequilibrium of chromosome 4 RFLP haplotypes and exclusion of a tight linkage between the disease and D4S43 locus.

Authors: E Ikonen; J Palo; J Ott; J Gusella; H Somer; L Karila; A Palotie; L Peltonen
Journal: Am J Hum Genet Date: 1990-01 Impact factor: 11.025

Allele frequencies and linkage disequilibrium of polymorphic DNA markers of the Huntington disease region in the German population.

1. PCR of a VNTR linked to mucopolysaccharidosis type I and Huntington disease.

2. A new DNA marker (D4S90) is located terminally on the short arm of chromosome 4, close to the Huntington disease gene.

3. A simple salting out procedure for extracting DNA from human nucleated cells.

4. Isolation of DNA markers in the direction of the Huntington disease gene from the G8 locus.

5. Increased recombination adjacent to the Huntington disease-linked D4S10 marker.

6. A polymorphic DNA marker genetically linked to Huntington's disease.

7. Recombination of 4p16 DNA markers in an unusual family with Huntington disease.

8. The Huntington's gene quest goes on.

9. Two additional RFLPs at the D4S10 locus, useful for Huntington's disease (HD)-family studies.

10. Huntington disease in Finland: linkage disequilibrium of chromosome 4 RFLP haplotypes and exclusion of a tight linkage between the disease and D4S43 locus.