Literature DB >> 1415218

Significant linkage disequilibrium between the Huntington disease gene and the loci D4S10 and D4S95 in the Dutch population.

M I Skraastad1, E Van de Vosse, R Belfroid, K Höld, M Vegter-van der Vlis, L A Sandkuijl, E Bakker, G J van Ommen.   

Abstract

Significant linkage disequilibrium has been found between the Huntington disease (HD) gene and DNA markers located around D4S95 and D4S98. The linkage-disequilibrium studies favor the proximal location of the HD gene, in contrast to the conflicting results of recombination analyses. We have analyzed 45 Dutch HD families with 19 DNA markers and have calculated the strength of linkage disequilibrium. Highly significant linkage disequilibrium has been detected with D4S95, consistent with the studies in other populations. In contrast with most other studies, however, the area of linkage disequilibrium extends from D4S10 proximally to D4S95, covering 1,100 kb. These results confirm that the HD gene most likely maps near D4S95.

Entities:  

Mesh：

Substances：

Year:  1992        PMID： 1415218      PMCID： PMC1682784     

Source DB:  PubMed          Journal:  Am J Hum Genet        ISSN： 0002-9297            Impact factor:   11.025


  25 in total

1.  Chromosome jumping from D4S10 (G8) toward the Huntington disease gene.

Authors:  J E Richards; T C Gilliam; J L Cole; M L Drumm; J J Wasmuth; J F Gusella; F S Collins
Journal:  Proc Natl Acad Sci U S A       Date:  1988-09       Impact factor: 11.205

2.  Recombination events suggest potential sites for the Huntington's disease gene.

Authors:  M E MacDonald; J L Haines; M Zimmer; S V Cheng; S Youngman; W L Whaley; N Wexler; M Bucan; B A Allitto; B Smith
Journal:  Neuron       Date:  1989-08       Impact factor: 17.173

3.  Isolation of DNA markers in the direction of the Huntington disease gene from the G8 locus.

Authors:  B Smith; D Skarecky; U Bengtsson; R E Magenis; N Carpenter; J J Wasmuth
Journal:  Am J Hum Genet       Date:  1988-02       Impact factor: 11.025

4.  An anonymous genomic clone that detects a frequent RFLP adjacent to the D4S10 (G8) marker and Huntington's disease.

Authors:  L R Carlock; T D Vo; C R DeHaven; J C Murray
Journal:  Nucleic Acids Res       Date:  1987-01-12       Impact factor: 16.971

5.  Non-random association between DNA markers and Huntington disease locus in the Italian population.

Authors:  A Novelletto; P Mandich; E Bellone; P Malaspina; G Vivona; F Ajmar; M Frontali
Journal:  Am J Med Genet       Date:  1991-09-01

6.  Non-random association between alleles detected at D4S95 and D4S98 and the Huntington's disease gene.

Authors:  J Theilmann; S Kanani; R Shiang; C Robbins; O Quarrell; M Huggins; A Hedrick; B Weber; C Collins; J J Wasmuth
Journal:  J Med Genet       Date:  1989-11       Impact factor: 6.318

7.  Clustering of multiallele DNA markers near the Huntington's disease gene.

Authors:  M E MacDonald; S V Cheng; M Zimmer; J L Haines; A Poustka; B Allitto; B Smith; W L Whaley; D M Romano; J Jagadeesh
Journal:  J Clin Invest       Date:  1989-09       Impact factor: 14.808

8.  Two additional RFLPs at the D4S10 locus, useful for Huntington's disease (HD)-family studies.

Authors:  E Bakker; M I Skraastad; Y M Fisser-Groen; G J van Ommen; P L Pearson
Journal:  Nucleic Acids Res       Date:  1987-11-11       Impact factor: 16.971

9.  Presymptomatic, prenatal, and exclusion testing for Huntington disease using seven closely linked DNA markers.

Authors:  M I Skraastad; A Verwest; E Bakker; M Vegter-van der Vlis; I van Leeuwen-Cornelisse; R A Roos; P L Pearson; G J van Ommen
Journal:  Am J Med Genet       Date:  1991-05-01

10.  Evidence from family studies that the gene causing Huntington disease is telomeric to D4S95 and D4S90.

Authors:  C Robbins; J Theilmann; S Youngman; J Haines; M J Altherr; P S Harper; C Payne; A Junker; J Wasmuth; M R Hayden
Journal:  Am J Hum Genet       Date:  1989-03       Impact factor: 11.025
View more
  8 in total

1.  Allelic association under map error and recombinational heterogeneity: a tale of two sites.

Authors:  C Lonjou; A Collins; R S Ajioka; L B Jorde; J P Kushner; N E Morton
Journal:  Proc Natl Acad Sci U S A       Date:  1998-09-15       Impact factor: 11.205

2.  Association mapping of disease loci, by use of a pooled DNA genomic screen.

Authors:  L F Barcellos; W Klitz; L L Field; R Tobias; A M Bowcock; R Wilson; M P Nelson; J Nagatomi; G Thomson
Journal:  Am J Hum Genet       Date:  1997-09       Impact factor: 11.025

3.  Likelihood methods for locating disease genes in nonequilibrium populations.

Authors:  N L Kaplan; W G Hill; B S Weir
Journal:  Am J Hum Genet       Date:  1995-01       Impact factor: 11.025

4.  Linkage disequilibrium patterns vary with chromosomal location: a case study from the von Willebrand factor region.

Authors:  W S Watkins; R Zenger; E O'Brien; D Nyman; A W Eriksson; M Renlund; L B Jorde
Journal:  Am J Hum Genet       Date:  1994-08       Impact factor: 11.025

5.  Linkage disequilibrium in the neurofibromatosis 1 (NF1) region: implications for gene mapping.

Authors:  L B Jorde; W S Watkins; D Viskochil; P O'Connell; K Ward
Journal:  Am J Hum Genet       Date:  1993-11       Impact factor: 11.025

6.  Linkage disequilibrium predicts physical distance in the adenomatous polyposis coli region.

Authors:  L B Jorde; W S Watkins; M Carlson; J Groden; H Albertsen; A Thliveris; M Leppert
Journal:  Am J Hum Genet       Date:  1994-05       Impact factor: 11.025

7.  Significant linkage disequilibrium between the Huntington's disease locus and markers at loci D4S10, D4S95, and D4S111 in Northern Ireland.

Authors:  P J Morrison; C A Graham; N C Nevin
Journal:  J Med Genet       Date:  1993-12       Impact factor: 6.318

8.  Allele frequencies and linkage disequilibrium of polymorphic DNA markers of the Huntington disease region in the German population.

Authors:  U Thies; B Bockel; B Gerdes; K Schröder
Journal:  Hum Genet       Date:  1993-12       Impact factor: 4.132
  8 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.