Literature DB >> 1386495

A recombination event that redefines the Huntington disease region.

R G Snell1, L M Thompson, D A Tagle, T L Holloway, G Barnes, H G Harley, L A Sandkuijl, M E MacDonald, F S Collins, J F Gusella.   

Abstract

We report both a recombination event that places the Huntington disease gene proximal to the marker D4S98 and an extended linkage-disequilibrium study that uses this marker and confirms the existence of disequilibrium between it and the HD locus. We also report the cloning of other sequences in the region around D4S98, including a new polymorphic marker R10 and conserved sequences that identify a gene in the region of interest.

Entities:  

Mesh：

Substances：

Year:  1992        PMID： 1386495      PMCID： PMC1682687     

Source DB:  PubMed          Journal:  Am J Hum Genet        ISSN： 0002-9297            Impact factor:   11.025


  21 in total

1.  A simple vacuum blotter design.

Authors:  R G Snell; D J Shaw
Journal:  Nucleic Acids Res       Date:  1991-11-11       Impact factor: 16.971

2.  Recombination events suggest potential sites for the Huntington's disease gene.

Authors:  M E MacDonald; J L Haines; M Zimmer; S V Cheng; S Youngman; W L Whaley; N Wexler; M Bucan; B A Allitto; B Smith
Journal:  Neuron       Date:  1989-08       Impact factor: 17.173

3.  Derivation of clones close to met by preparative field inversion gel electrophoresis.

Authors:  F Michiels; M Burmeister; H Lehrach
Journal:  Science       Date:  1987-06-05       Impact factor: 47.728

4.  A polymorphic DNA marker genetically linked to Huntington's disease.

Authors:  J F Gusella; N S Wexler; P M Conneally; S L Naylor; M A Anderson; R E Tanzi; P C Watkins; K Ottina; M R Wallace; A Y Sakaguchi
Journal:  Nature       Date:  1983 Nov 17-23       Impact factor: 49.962

5.  Non-random association between alleles detected at D4S95 and D4S98 and the Huntington's disease gene.

Authors:  J Theilmann; S Kanani; R Shiang; C Robbins; O Quarrell; M Huggins; A Hedrick; B Weber; C Collins; J J Wasmuth
Journal:  J Med Genet       Date:  1989-11       Impact factor: 6.318

6.  Linkage disequilibrium and modification of risk for Huntington disease.

Authors:  S Adam; J Theilmann; K Buetow; A Hedrick; C Collins; B Weber; M Huggins; M Hayden
Journal:  Am J Hum Genet       Date:  1991-03       Impact factor: 11.025

7.  A somatic cell hybrid panel for localizing DNA segments near the Huntington's disease gene.

Authors:  M E MacDonald; M A Anderson; T C Gilliam; L Tranejaerg; N J Carpenter; E Magenis; M R Hayden; S T Healey; T I Bonner; J F Gusella
Journal:  Genomics       Date:  1987-09       Impact factor: 5.736

8.  Defined physical limits of the Huntington disease gene candidate region.

Authors:  G P Bates; M E MacDonald; S Baxendale; S Youngman; C Lin; W L Whaley; J J Wasmuth; J F Gusella; H Lehrach
Journal:  Am J Hum Genet       Date:  1991-07       Impact factor: 11.025

9.  Fine mapping of the Huntington disease linked D4S10 locus by non-radioactive in situ hybridization.

Authors:  J E Landegent; N Jansen in de Wal; Y M Fisser-Groen; E Bakker; M van der Ploeg; P L Pearson
Journal:  Hum Genet       Date:  1986-08       Impact factor: 4.132

10.  A cell hybrid and recombinant DNA library that facilitate identification of polymorphic loci in the vicinity of the Huntington disease gene.

Authors:  J J Wasmuth; L R Carlock; B Smith; L L Immken
Journal:  Am J Hum Genet       Date:  1986-09       Impact factor: 11.025
View more
  3 in total

1.  Defining the location of the Huntington disease gene.

Authors:  D M Danks
Journal:  Am J Hum Genet       Date:  1993-01       Impact factor: 11.025

2.  Significant linkage disequilibrium between the Huntington's disease locus and markers at loci D4S10, D4S95, and D4S111 in Northern Ireland.

Authors:  P J Morrison; C A Graham; N C Nevin
Journal:  J Med Genet       Date:  1993-12       Impact factor: 6.318

3.  Allele frequencies and linkage disequilibrium of polymorphic DNA markers of the Huntington disease region in the German population.

Authors:  U Thies; B Bockel; B Gerdes; K Schröder
Journal:  Hum Genet       Date:  1993-12       Impact factor: 4.132
  3 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.