Literature DB >> 2138410

A yeast artificial chromosome telomere clone spanning a possible location of the Huntington disease gene.

G P Bates1, M E MacDonald, S Baxendale, Z Sedlacek, S Youngman, D Romano, W L Whaley, B A Allitto, A Poustka, J F Gusella.   

Abstract

The Huntington disease (HD) gene has been mapped to the most distal subband of chromosome 4p. Analysis of recombination events has not provided an unequivocal location of the HD gene, but it indicates a position very close to the telomere as one possibility. We have constructed a yeast artificial chromosome (YAC) vector (containing a rare-cutter polylinker) for the cloning of mammalian telomeres, used it to prepare a BssHII-telomere library with DNA from an individual homozygous for HD, and have identified a 115-kb clone containing the telomere of 4p. One probable recombinant would confine the telomeric candidate location for the gene to the region covered by the YAC, which makes it possible that the clone described here contains the HD locus in its mutant form.

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Year:  1990        PMID： 2138410      PMCID： PMC1683659     

Source DB:  PubMed          Journal:  Am J Hum Genet        ISSN： 0002-9297            Impact factor:   11.025


  47 in total

1.  Conservation of the human telomere sequence (TTAGGG)n among vertebrates.

Authors:  J Meyne; R L Ratliff; R K Moyzis
Journal:  Proc Natl Acad Sci U S A       Date:  1989-09       Impact factor: 11.205

2.  Isolation of DNA markers in the direction of the Huntington disease gene from the G8 locus.

Authors:  B Smith; D Skarecky; U Bengtsson; R E Magenis; N Carpenter; J J Wasmuth
Journal:  Am J Hum Genet       Date:  1988-02       Impact factor: 11.025

3.  Isolation of genomic DNA.

Authors:  B G Herrmann; A M Frischauf
Journal:  Methods Enzymol       Date:  1987       Impact factor: 1.600

4.  A DNA probe, D5 [D4S90] mapping to human chromosome 4p16.3.

Authors:  S Youngman; D J Shaw; J F Gusella; M MacDonald; E J Stanbridge; J Wasmuth; P S Harper
Journal:  Nucleic Acids Res       Date:  1988-02-25       Impact factor: 16.971

5.  Linkage disequilibrium in Huntington's disease: an improved localisation for the gene.

Authors:  R G Snell; L P Lazarou; S Youngman; O W Quarrell; J J Wasmuth; D J Shaw; P S Harper
Journal:  J Med Genet       Date:  1989-11       Impact factor: 6.318

6.  Isolation and characterization of a human telomere.

Authors:  J F Cheng; C L Smith; C R Cantor
Journal:  Nucleic Acids Res       Date:  1989-08-11       Impact factor: 16.971

7.  Localization of the Huntington's disease gene to a small segment of chromosome 4 flanked by D4S10 and the telomere.

Authors:  T C Gilliam; R E Tanzi; J L Haines; T I Bonner; A G Faryniarz; W J Hobbs; M E MacDonald; S V Cheng; S E Folstein; P M Conneally
Journal:  Cell       Date:  1987-08-14       Impact factor: 41.582

8.  A somatic cell hybrid panel for localizing DNA segments near the Huntington's disease gene.

Authors:  M E MacDonald; M A Anderson; T C Gilliam; L Tranejaerg; N J Carpenter; E Magenis; M R Hayden; S T Healey; T I Bonner; J F Gusella
Journal:  Genomics       Date:  1987-09       Impact factor: 5.736

9.  Predictive testing for Huntington's disease with use of a linked DNA marker.

Authors:  G J Meissen; R H Myers; C A Mastromauro; W J Koroshetz; K W Klinger; L A Farrer; P A Watkins; J F Gusella; E D Bird; J B Martin
Journal:  N Engl J Med       Date:  1988-03-03       Impact factor: 91.245

10.  A highly polymorphic locus very tightly linked to the Huntington's disease gene.

Authors:  J J Wasmuth; J Hewitt; B Smith; D Allard; J L Haines; D Skarecky; E Partlow; M R Hayden
Journal:  Nature       Date:  1988-04-21       Impact factor: 49.962
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  18 in total

1.  A molecular deletion of distal chromosome 4p in two families with a satellited chromosome 4 lacking the Wolf-Hirschhorn syndrome phenotype.

Authors:  L L Estabrooks; A N Lamb; H N Kirkman; N P Callanan; K W Rao
Journal:  Am J Hum Genet       Date:  1992-11       Impact factor: 11.025

Review 2.  Minireview: cryptic translocations and telomere integrity.

Authors:  D H Ledbetter
Journal:  Am J Hum Genet       Date:  1992-09       Impact factor: 11.025

3.  The end in sight for Huntington disease?

Authors:  C Pritchard; D R Cox; R M Myers
Journal:  Am J Hum Genet       Date:  1991-07       Impact factor: 11.025

4.  Genomic organization and complete sequence of the human gene encoding the beta-subunit of the cGMP phosphodiesterase and its localisation to 4p 16.3.

Authors:  B Weber; O Riess; G Hutchinson; C Collins; B Y Lin; D Kowbel; S Andrew; K Schappert; M R Hayden
Journal:  Nucleic Acids Res       Date:  1991-11-25       Impact factor: 16.971

Review 5.  Telomere shortening and Alzheimer's disease.

Authors:  Zhiyou Cai; Liang-Jun Yan; Anna Ratka
Journal:  Neuromolecular Med       Date:  2012-11-16       Impact factor: 3.843

6.  Complex patterns of linkage disequilibrium in the Huntington disease region.

Authors:  M E MacDonald; C Lin; L Srinidhi; G Bates; M Altherr; W L Whaley; H Lehrach; J Wasmuth; J F Gusella
Journal:  Am J Hum Genet       Date:  1991-10       Impact factor: 11.025

7.  Evidence for the organization of chromatin in megabase pair-sized loops arranged along a random walk path in the human G0/G1 interphase nucleus.

Authors:  H Yokota; G van den Engh; J E Hearst; R K Sachs; B J Trask
Journal:  J Cell Biol       Date:  1995-09       Impact factor: 10.539

8.  Identification, characterisation and clinical applications of cosmids from the telomeric and centromeric regions of the long arm of chromosome 22.

Authors:  Y G Xie; F Y Han; S Bajalica; E Blennow; U Kristoffersson; J P Dumanski; M Nordenskjöld
Journal:  Hum Genet       Date:  1994-10       Impact factor: 4.132

9.  The DNA rearrangement associated with facioscapulohumeral muscular dystrophy involves a heterochromatin-associated repetitive element: implications for a role of chromatin structure in the pathogenesis of the disease.

Authors:  S T Winokur; U Bengtsson; J Feddersen; K D Mathews; B Weiffenbach; H Bailey; R P Markovich; J C Murray; J J Wasmuth; M R Altherr
Journal:  Chromosome Res       Date:  1994-05       Impact factor: 5.239

10.  Recombination of 4p16 DNA markers in an unusual family with Huntington disease.

Authors:  C Pritchard; N Zhu; J Zuo; L Bull; M A Pericak-Vance; J M Vance; A D Roses; A Milatovich; U Francke; D R Cox
Journal:  Am J Hum Genet       Date:  1992-06       Impact factor: 11.025
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