Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Clustering of multiallele DNA markers near the Huntington's disease gene.

Literature DB >> 2569477

Clustering of multiallele DNA markers near the Huntington's disease gene.

M E MacDonald¹, S V Cheng, M Zimmer, J L Haines, A Poustka, B Allitto, B Smith, W L Whaley, D M Romano, J Jagadeesh.

Abstract

Five highly informative multiallele restriction fragment length polymorphisms (RFLPs) of value for preclinical diagnosis of Huntington's disease (HD) have been genetically characterized. One RFLP was uncovered by expansion of the D4S43 locus while three others are at D4S111 and D4S115, loci defined by NotI-linking clones. The final marker, D4S125, represents a recently discovered VNTR locus. All four loci map closer to the HD gene and to the telomere than D4S10, the original linked marker for HD. In combination with two multiallele RFLPs previously identified for D4S43 and another linked locus, D4S95, these five new multiallele markers will dramatically improve the speed and accuracy of predictive testing in HD, and increase its applicability by maximizing the chances of an informative test for anyone with appropriate family structure.

Entities: Disease

Mesh：

Substances：

Year: 1989 PMID： 2569477 PMCID： PMC329749 DOI： 10.1172/JCI114222

Source DB: PubMed Journal: J Clin Invest ISSN： 0021-9738 Impact factor: 14.808

21 in total

1. A DNA polymorphism for Huntington's disease marks the future.

Authors: N S Wexler; P M Conneally; D Housman; J F Gusella
Journal: Arch Neurol Date: 1985-01

2. Precise localization of human beta-globin gene complex on chromosome 11.

Authors: J Gusella; A Varsanyi-Breiner; F T Kao; C Jones; T T Puck; C Keys; S Orkin; D Housman
Journal: Proc Natl Acad Sci U S A Date: 1979-10 Impact factor: 11.205

3. Report of the Committee on Methods of Linkage Analysis and Reporting.

Authors: P M Conneally; J H Edwards; K K Kidd; J M Lalouel; N E Morton; J Ott; R White
Journal: Cytogenet Cell Genet Date: 1985

4. DNA markers for nervous system diseases.

Authors: J F Gusella; R E Tanzi; M A Anderson; W Hobbs; K Gibbons; R Raschtchian; T C Gilliam; M R Wallace; N S Wexler; P M Conneally
Journal: Science Date: 1984-09-21 Impact factor: 47.728

5. Genetic linkage map of human chromosome 21.

Authors: R E Tanzi; J L Haines; P C Watkins; G D Stewart; M R Wallace; R Hallewell; C Wong; N S Wexler; P M Conneally; J F Gusella
Journal: Genomics Date: 1988-08 Impact factor: 5.736

6. Isolation of polymorphic DNA fragments from human chromosome 4.

Authors: T C Gilliam; S T Healey; M E MacDonald; G D Stewart; J J Wasmuth; R E Tanzi; J C Roy; J F Gusella
Journal: Nucleic Acids Res Date: 1987-02-25 Impact factor: 16.971

Review 7. Huntington's disease. Pathogenesis and management.

Authors: J B Martin; J F Gusella
Journal: N Engl J Med Date: 1986-11-13 Impact factor: 91.245

8. "A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity". Addendum.

Authors: A P Feinberg; B Vogelstein
Journal: Anal Biochem Date: 1984-02 Impact factor: 3.365

9. A polymorphic DNA marker genetically linked to Huntington's disease.

Authors: J F Gusella; N S Wexler; P M Conneally; S L Naylor; M A Anderson; R E Tanzi; P C Watkins; K Ottina; M R Wallace; A Y Sakaguchi
Journal: Nature Date: 1983 Nov 17-23 Impact factor: 49.962

10. Strategies for multilocus linkage analysis in humans.

Authors: G M Lathrop; J M Lalouel; C Julier; J Ott
Journal: Proc Natl Acad Sci U S A Date: 1984-06 Impact factor: 11.205

16 in total

1. PCR detection of a biallelic polymorphism at D4S43.

Authors: M Majer; B Gerdes; C Zühlke; U Thies
Journal: Nucleic Acids Res Date: 1992-02-25 Impact factor: 16.971

2. MboI RFLP at the D4S43 (C4H) locus.

Authors: L P Lazarou; R G Snell; M E MacDonald; J F Gusella; J J Wasmuth; D J Shaw
Journal: Nucleic Acids Res Date: 1991-10-11 Impact factor: 16.971

3. Detection by PCR of a VNTR polymorphism at D4S43.

Authors: G T Horn; A I McClatchey; B Richards; M E MacDonald; J F Gusella
Journal: Nucleic Acids Res Date: 1991-09-11 Impact factor: 16.971

4. Studies on DNA markers (D4S10 and D4S43/S127) genetically linked to Huntington's disease in Japanese families.

Authors: I Kanazawa; I Kondo; J E Ikeda; T Ikeda; Y Shizu; M Yoshida; H Narabayashi; S Kuroda; H Tsunoda; E Mizuta
Journal: Hum Genet Date: 1990-08 Impact factor: 4.132

5. Epidemiological and linkage studies on Huntington's disease in Italy.

Authors: M Frontali; P Malaspina; C Rossi; A G Jacopini; G Vivona; M S Pergola; A Palena; A Novelletto
Journal: Hum Genet Date: 1990-07 Impact factor: 4.132

6. Complex patterns of linkage disequilibrium in the Huntington disease region.

Authors: M E MacDonald; C Lin; L Srinidhi; G Bates; M Altherr; W L Whaley; H Lehrach; J Wasmuth; J F Gusella
Journal: Am J Hum Genet Date: 1991-10 Impact factor: 11.025

7. Defining the location of the Huntington disease gene.

Authors: D M Danks
Journal: Am J Hum Genet Date: 1993-01 Impact factor: 11.025

8. A recombination event that redefines the Huntington disease region.

Authors: R G Snell; L M Thompson; D A Tagle; T L Holloway; G Barnes; H G Harley; L A Sandkuijl; M E MacDonald; F S Collins; J F Gusella
Journal: Am J Hum Genet Date: 1992-08 Impact factor: 11.025

9. Linkage, but not gene order, of homologous loci, including alpha-L-iduronidase (Idua), is conserved in the Huntington disease region of the mouse and human genomes.

Authors: T Koizumi; M MacDonald; M Búcan; J J Hopwood; C P Morris; H S Scott; J F Gusella; J H Nadeau
Journal: Mamm Genome Date: 1992 Impact factor: 2.957

10. Isolation and characterization of new highly polymorphic DNA markers from the Huntington disease region.

Authors: B Weber; A Hedrick; S Andrew; O Riess; C Collins; D Kowbel; M R Hayden
Journal: Am J Hum Genet Date: 1992-02 Impact factor: 11.025