Literature DB >> 8133499

Significant linkage disequilibrium between the Huntington's disease locus and markers at loci D4S10, D4S95, and D4S111 in Northern Ireland.

P J Morrison1, C A Graham, N C Nevin.   

Abstract

An analysis of the Northern Ireland Huntington's disease (HD) population of 75 families showed significant linkage disequilibrium between the HD gene and DNA markers at D4S95, D4S10, and D4S111. As the linkage disequilibrium at loci D4S10 and D4S111 is different from previous studies in the UK, but similar at locus D4S95, this suggests either that the HD mutation(s) in the Northern Ireland and British populations is not of common origin or that the haplotype of the common HD mutation has changed over time subsequent to divergence from a common origin.

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Year:  1993        PMID： 8133499      PMCID： PMC1016636          DOI： 10.1136/jmg.30.12.1018

Source DB:  PubMed          Journal:  J Med Genet        ISSN： 0022-2593            Impact factor:   6.318


  15 in total

1.  Detection by PCR of a VNTR polymorphism at D4S43.

Authors:  G T Horn; A I McClatchey; B Richards; M E MacDonald; J F Gusella
Journal:  Nucleic Acids Res       Date:  1991-09-11       Impact factor: 16.971

2.  Characterization and rapid analysis of the highly polymorphic VNTR locus D4S125 (YNZ32), closely linked to the Huntington disease gene.

Authors:  B Richards; G T Horn; J J Merrill; K W Klinger
Journal:  Genomics       Date:  1991-02       Impact factor: 5.736

3.  A rapid method for the purification of DNA from blood.

Authors:  M Jeanpierre
Journal:  Nucleic Acids Res       Date:  1987-11-25       Impact factor: 16.971

4.  PCR of a KpnI RFLP in the alpha-L-iduronidase (IDUA) gene.

Authors:  H S Scott; P V Nelson; J J Hopwood; C P Morris
Journal:  Nucleic Acids Res       Date:  1991-10-25       Impact factor: 16.971

Review 5.  [Radiotherapy of Hodgkin's disease].

Authors:  M B Patrício
Journal:  Acta Med Port       Date:  1990 Jan-Feb

6.  Non-random association between alleles detected at D4S95 and D4S98 and the Huntington's disease gene.

Authors:  J Theilmann; S Kanani; R Shiang; C Robbins; O Quarrell; M Huggins; A Hedrick; B Weber; C Collins; J J Wasmuth
Journal:  J Med Genet       Date:  1989-11       Impact factor: 6.318

7.  Linkage disequilibrium in Huntington's disease: an improved localisation for the gene.

Authors:  R G Snell; L P Lazarou; S Youngman; O W Quarrell; J J Wasmuth; D J Shaw; P S Harper
Journal:  J Med Genet       Date:  1989-11       Impact factor: 6.318

8.  Prenatal exclusion testing for Huntington disease using the polymerase chain reaction.

Authors:  I McIntosh; A Curtis; F A Millan; D J Brock
Journal:  Am J Med Genet       Date:  1989-02

Review 9.  The Huntington's disease candidate region exhibits many different haplotypes.

Authors:  M E MacDonald; A Novelletto; C Lin; D Tagle; G Barnes; G Bates; S Taylor; B Allitto; M Altherr; R Myers
Journal:  Nat Genet       Date:  1992-05       Impact factor: 38.330

10.  Linkage disequilibrium and recombination make a telomeric site for the Huntington's disease gene unlikely.

Authors:  L Barron; A Curtis; A E Shrimpton; S Holloway; H May; R G Snell; D J Brock
Journal:  J Med Genet       Date:  1991-08       Impact factor: 6.318
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  3 in total

1.  Allelic association under map error and recombinational heterogeneity: a tale of two sites.

Authors:  C Lonjou; A Collins; R S Ajioka; L B Jorde; J P Kushner; N E Morton
Journal:  Proc Natl Acad Sci U S A       Date:  1998-09-15       Impact factor: 11.205

2.  Linkage disequilibrium at the Machado-Joseph disease/spinal cerebellar ataxia 3 locus: evidence for a common founder effect in French and Portuguese-Brazilian families as well as a second ancestral Portuguese-Azorean mutation.

Authors:  G Stevanin; G Cancel; O Didierjean; A Dürr; N Abbas; E Cassa; J Feingold; Y Agid; A Brice
Journal:  Am J Hum Genet       Date:  1995-11       Impact factor: 11.025

3.  The epidemiology of Huntington's disease in Northern Ireland.

Authors:  P J Morrison; W P Johnston; N C Nevin
Journal:  J Med Genet       Date:  1995-07       Impact factor: 6.318
  3 in total

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