BACKGROUND: Positron emission tomography (PET) attenuation correction (AC) using computed tomography (CT) can be affected by respiratory motion: hi-speed CT captures 1 point of the respiratory cycle while PET emission data averages many cycles. We quantified the changes in apparent myocardial uptake due to this respiratory-induced CT attenuation mismatch. METHODS: Twenty-two patients undergoing fluorine-18 fluorodeoxyglucose (FDG) PET/CT received 3 sequential CT scans at normal resting end-inspiration (CT(INSPIR)), ending expiration (CT(EXPIR)), and at midvolume between end-expiration and end-inspiration (CT(MIDVOL)). A pneumotachometer measured absolute changes in lung volume. Seven subjects also underwent a 3-minute transmission scan with a 68Ge rotating rod source (RRS). The PET emission data set was reconstructed up to 4 times using CT(EXPIR), CT(INSPIR), CT(MIDVOL), and RRS AC maps. Relative heart position and cardiac uptake was measured for each CT attenuation correction. RESULTS: Respiratory motion produced marked changes in global and regional myocardial uptake. Changes were large in the lateral and anterior regions at the lung-soft tissue interface (up to 30% using CT(INSPIR) compared to CT(EXPIR) for AC) and smaller in the septal region (10% or less). Data corrected with CT(EXPIR) agreed best with the RRS. CONCLUSION: Respiratory effects can introduce large inhomogeneities in apparent myocardial uptake when CT is used for attenuation correction.
BACKGROUND: Positron emission tomography (PET) attenuation correction (AC) using computed tomography (CT) can be affected by respiratory motion: hi-speed CT captures 1 point of the respiratory cycle while PET emission data averages many cycles. We quantified the changes in apparent myocardial uptake due to this respiratory-induced CT attenuation mismatch. METHODS: Twenty-two patients undergoing fluorine-18 fluorodeoxyglucose (FDG) PET/CT received 3 sequential CT scans at normal resting end-inspiration (CT(INSPIR)), ending expiration (CT(EXPIR)), and at midvolume between end-expiration and end-inspiration (CT(MIDVOL)). A pneumotachometer measured absolute changes in lung volume. Seven subjects also underwent a 3-minute transmission scan with a 68Ge rotating rod source (RRS). The PET emission data set was reconstructed up to 4 times using CT(EXPIR), CT(INSPIR), CT(MIDVOL), and RRS AC maps. Relative heart position and cardiac uptake was measured for each CT attenuation correction. RESULTS: Respiratory motion produced marked changes in global and regional myocardial uptake. Changes were large in the lateral and anterior regions at the lung-soft tissue interface (up to 30% using CT(INSPIR) compared to CT(EXPIR) for AC) and smaller in the septal region (10% or less). Data corrected with CT(EXPIR) agreed best with the RRS. CONCLUSION: Respiratory effects can introduce large inhomogeneities in apparent myocardial uptake when CT is used for attenuation correction.
Authors: S A Nehmeh; Y E Erdi; T Pan; E Yorke; G S Mageras; K E Rosenzweig; H Schoder; H Mostafavi; O Squire; A Pevsner; S M Larson; J L Humm Journal: Med Phys Date: 2004-06 Impact factor: 4.071
Authors: Yusuf E Erdi; Sadek A Nehmeh; Tinsu Pan; Alexander Pevsner; Kenneth E Rosenzweig; Gikas Mageras; Ellen D Yorke; Heiko Schoder; Wendy Hsiao; Olivia D Squire; Phil Vernon; Jonathan B Ashman; Hassan Mostafavi; Steven M Larson; John L Humm Journal: J Nucl Med Date: 2004-08 Impact factor: 10.057
Authors: Yuji Nakamoto; Bennett B Chin; Christian Cohade; Medhat Osman; Mitsuaki Tatsumi; Richard L Wahl Journal: Nucl Med Commun Date: 2004-03 Impact factor: 1.690
Authors: Pascal Koepfli; Thomas F Hany; Christophe A Wyss; Mehdi Namdar; Cyrill Burger; Alexander V Konstantinidis; Thomas Berthold; Gustav K Von Schulthess; Philipp A Kaufmann Journal: J Nucl Med Date: 2004-04 Impact factor: 10.057
Authors: Tinsu Pan; Osama Mawlawi; Sadek A Nehmeh; Yusuf E Erdi; Dershan Luo; Hui H Liu; Richard Castillo; Radhe Mohan; Zhongxing Liao; H A Macapinlac Journal: J Nucl Med Date: 2005-09 Impact factor: 10.057
Authors: S A Nehmeh; Y E Erdi; T Pan; A Pevsner; K E Rosenzweig; E Yorke; G S Mageras; H Schoder; Phil Vernon; O Squire; H Mostafavi; S M Larson; J L Humm Journal: Med Phys Date: 2004-12 Impact factor: 4.071
Authors: C Riddell; R E Carson; J A Carrasquillo; S K Libutti; D N Danforth; M Whatley; S L Bacharach Journal: J Nucl Med Date: 2001-09 Impact factor: 10.057
Authors: Michael A King; Joyoni Dey; Karen Johnson; Paul Dasari; Joyeeta M Mukherjee; Joseph E McNamara; Arda Konik; Cliff Lindsay; Shaokuan Zheng; Dennis Coughlin Journal: Med Phys Date: 2013-11 Impact factor: 4.071