| Literature DB >> 915918 |
J D Warren, D L Woodward, R T Hargreaves.
Abstract
Twelve 4-substituted semicarbazone derivatives of o- and p-chloro- as well as 2,6-dichlorobenzaldehyde were synthesized and investigated for antihypertensive activity in spontaneously hypertensive rats. Several of the compounds synthesized (viz. 1, 6, 7, and 15) exhibited potent antihypertensive effects when orally administered. The same compounds were not hypotensive in the normotensive dog.Entities:
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Year: 1977 PMID： 915918 DOI： 10.1021/jm00221a034
Source DB: PubMed Journal: J Med Chem ISSN： 0022-2623 Impact factor: 7.446