Literature DB >> 7325157

Heritable fragile sites on human chromosomes. VII. Children homozygous for the BrdU-requiring fra(10)(q25) are phenotypically normal.

G R Sutherland.   

Abstract

A brother and sister have been detected who are homozygous for the bromodeoxyuridine (BrdU)-requiring fragile site at 10q25. The children are phenotypically normal, indicating that homozygosity for this fragile site is harmless, at least during childhood.

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Year:  1981        PMID： 7325157      PMCID： PMC1685152     

Source DB:  PubMed          Journal:  Am J Hum Genet        ISSN： 0002-9297            Impact factor:   11.025


  6 in total

1.  Heritable fragile sites on human chromosomes II. Distribution, phenotypic effects, and cytogenetics.

Authors:  G R Sutherland
Journal:  Am J Hum Genet       Date:  1979-03       Impact factor: 11.025

2.  A homozygous chromosomal variant.

Authors:  J M Berg; J A Faunch; M J Pendrey; L S Penrose; M A Ridler; A Shapiro
Journal:  Lancet       Date:  1969-03-08       Impact factor: 79.321

3.  Demonstration of a heritable fragile site in human chromosome 16 with distamycin A.

Authors:  M Schmid; C Klett; A Niederhofer
Journal:  Cytogenet Cell Genet       Date:  1980

4.  Heritable fragile sites and lymphocyte culture medium containing BrdU.

Authors:  J M Scheres; T W Hustinx
Journal:  Am J Hum Genet       Date:  1980-07       Impact factor: 11.025

5.  Heritable fragile sites on human chromosomes. V. A new class of fragile site requiring BrdU for expression.

Authors:  G R Sutherland; E Baker; R S Seshadri
Journal:  Am J Hum Genet       Date:  1980-07       Impact factor: 11.025

6.  Heterozygous expression of X-linked mental retardation and X-chromosome marker fra(X)(q27).

Authors:  G Turner; R Brookwell; A Daniel; M Selikowitz; M Zilibowitz
Journal:  N Engl J Med       Date:  1980-09-18       Impact factor: 91.245
  6 in total
  12 in total

1.  Homozygotes for FRA16B are normal.

Authors:  T Hocking; W Feichtinger; M Schmid; E A Haan; E Baker; G R Sutherland
Journal:  Chromosome Res       Date:  1999       Impact factor: 5.239

2.  Homozygous condition for a BrdU-requiring fragile site on chromosome 12.

Authors:  I Voiculescu; E Back; W Schempp
Journal:  Hum Genet       Date:  1991-02       Impact factor: 4.132

3.  A BrdU-requiring fragile site on chromosome 12.

Authors:  I Voiculescu; C Hausmann; G Wolff; E Back
Journal:  Hum Genet       Date:  1988-02       Impact factor: 4.132

4.  The fragile site (16) (q22). I. Induction by AT-specific DNA-ligands and population frequency.

Authors:  M Schmid; W Feichtinger; A Jessberger; J Köhler; R Lange
Journal:  Hum Genet       Date:  1986-09       Impact factor: 4.132

5.  Expression of fragile site at 10q25 in normal culture conditions.

Authors:  P Petit; J P Fryns
Journal:  Am J Hum Genet       Date:  1983-01       Impact factor: 11.025

6.  Heritable fragile sites on human chromosomes. X. New folate-sensitive fragile sites: 6p23, 9p21, 9q32, and 11q23.

Authors:  G R Sutherland; P B Jacky; E Baker; A Manuel
Journal:  Am J Hum Genet       Date:  1983-05       Impact factor: 11.025

7.  BrdU-sensitive fragile site on long arm of chromosome 16.

Authors:  G Croci
Journal:  Am J Hum Genet       Date:  1983-05       Impact factor: 11.025

Review 8.  Fragility Extraordinaire: Unsolved Mysteries of Chromosome Fragile Sites.

Authors:  Wenyi Feng; Arijita Chakraborty
Journal:  Adv Exp Med Biol       Date:  2017       Impact factor: 2.622

9.  Spontaneous expression of the chromosome fragile site fra(10)(q25).

Authors:  A M Taylor; S Bundey
Journal:  Am J Hum Genet       Date:  1983-01       Impact factor: 11.025

10.  Homozygosity for fragile site at 17p12 in a 28-year-old healthy man.

Authors:  V Izakovic
Journal:  Hum Genet       Date:  1984       Impact factor: 4.132
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