Literature DB >> 7449440

Demonstration of a heritable fragile site in human chromosome 16 with distamycin A.

M Schmid, C Klett, A Niederhofer.   

Abstract

Fragile sites are induced in chromosome 16 (band q22) of lymphocytes from some individuals, when the lymphocyte cultures are treated with the oligopeptide antibiotic distamycin A. These induced fragile sites are inherited in a Mendelian fashion; there are interfamilial differences in their appearance. The interactions between distamycin A and chromosomal DNA and the possible composition of the DNA at the induced fragile sites are discussed.

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Year:  1980        PMID： 7449440     DOI： 10.1159/000131516

Source DB:  PubMed          Journal:  Cytogenet Cell Genet        ISSN： 0301-0171


  20 in total

1.  Fragile site (16) (q22). III. Segregation analysis.

Authors:  B Müller; W Feichtinger; C Bonaïti-Pellié; M Schmid
Journal:  Hum Genet       Date:  1992-08       Impact factor: 4.132

2.  "Spontaneous" FRA16B is a hot spot for sister chromatid exchanges.

Authors:  T Lukusa; E Meulepas; J P Fryns; H Van den Berghe; J J Cassiman
Journal:  Hum Genet       Date:  1991-09       Impact factor: 4.132

3.  The fragile site (16) (q22). I. Induction by AT-specific DNA-ligands and population frequency.

Authors:  M Schmid; W Feichtinger; A Jessberger; J Köhler; R Lange
Journal:  Hum Genet       Date:  1986-09       Impact factor: 4.132

4.  The fragile site (17)(p12): induction by AT-specific DNA-ligands and population cytogenetics.

Authors:  M Schmid; W Feichtinger; C Deubelbeiss; E Weller
Journal:  Hum Genet       Date:  1987-10       Impact factor: 4.132

5.  The fragile site (16)(q22). II. Sister chromatid exchanges.

Authors:  M Schmid; W Feichtinger; T Haaf
Journal:  Hum Genet       Date:  1987-08       Impact factor: 4.132

6.  Autosomal fragile sites not a current indication for prenatal diagnosis.

Authors:  F Hecht; B K Hecht
Journal:  Hum Genet       Date:  1984       Impact factor: 4.132

7.  BrdU-sensitive fragile site on long arm of chromosome 16.

Authors:  G Croci
Journal:  Am J Hum Genet       Date:  1983-05       Impact factor: 11.025

8.  Fragile sites and structural rearrangements in cancer.

Authors:  M De Braekeleer; B Smith; C C Lin
Journal:  Hum Genet       Date:  1985       Impact factor: 4.132

9.  The use of distamycin A in human lymphocyte cultures.

Authors:  M Schmid; D A Hungerford; A Poppen; W Engel
Journal:  Hum Genet       Date:  1984       Impact factor: 4.132

10.  Secondary structure formation and DNA instability at fragile site FRA16B.

Authors:  Allison A Burrow; Allison Marullo; Lindsay R Holder; Yuh-Hwa Wang
Journal:  Nucleic Acids Res       Date:  2010-01-13       Impact factor: 16.971
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