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Literature DB >> 7395866

Heritable fragile sites on human chromosomes. V. A new class of fragile site requiring BrdU for expression.

Abstract

A new fragile site at 10q25 is described, representing a new class of fragile site that requires bromodeoxyuridine (BrdU) in the culture medium for expression. This new fragile site is present in approximately one in 30 of the Australian population; it has only been observed in heterozygotes.

Entities: Chemical Gene Species

Mesh：

Substances：

Year: 1980 PMID： 7395866 PMCID： PMC1686118

Source DB: PubMed Journal: Am J Hum Genet ISSN： 0002-9297 Impact factor: 11.025

12 in total

1. Fragile sites on human chromosomes: demonstration of their dependence on the type of tissue culture medium.

Authors: G R Sutherland
Journal: Science Date: 1977-07-15 Impact factor: 47.728

2. Heritable fragile sites on human chromosomes I. Factors affecting expression in lymphocyte culture.

Authors: G R Sutherland
Journal: Am J Hum Genet Date: 1979-03 Impact factor: 11.025

3. The importance of being a fragile site.

Authors: F Hecht; B Kaiser-McCaw
Journal: Am J Hum Genet Date: 1979-03 Impact factor: 11.025

4. Heritable fragile sites on human chromosomes II. Distribution, phenotypic effects, and cytogenetics.

Authors: G R Sutherland
Journal: Am J Hum Genet Date: 1979-03 Impact factor: 11.025

5. Microfluorometric detection of deoxyribonucleic acid replication in human metaphase chromosomes.

Authors: S A Latt
Journal: Proc Natl Acad Sci U S A Date: 1973-12 Impact factor: 11.205

6. 5-bromodeoxyuridine-induced constrictions in human chromosomes.

Authors: C G Palmer
Journal: Can J Genet Cytol Date: 1970-12

7. Giemsa technique for the detection of sister chromatid exchanges.

Authors: J R Korenberg; E F Freedlender
Journal: Chromosoma Date: 1974 Impact factor: 4.316

8. [The mechanism of chromosome segmentation induced by BUDR (5-bromodeoxyuridine)].

Authors: B Dutrillaux; A M Fosse
Journal: Ann Genet Date: 1974-09

9. Direct evidence for the role of incorporated BUdR in the induction of sister chromatid exchanges.

Authors: J A Mazrimas; D G Stetka
Journal: Exp Cell Res Date: 1978-11 Impact factor: 3.905

10. Differential spiralization along mammalian mitotic chromosomes. II. 5-bromodeoxyuridine and 5-bromodeoxycytidine-revealed differentiation in human chromosomes.

Authors: A F Zakharov; L I Baranovskaya; A I Ibraimov; V A Benjusch; V S Demintseva; N G Oblapenko
Journal: Chromosoma Date: 1974-01-29 Impact factor: 4.316

23 in total

1. "Spontaneous" FRA16B is a hot spot for sister chromatid exchanges.

Authors: T Lukusa; E Meulepas; J P Fryns; H Van den Berghe; J J Cassiman
Journal: Hum Genet Date: 1991-09 Impact factor: 4.132

2. Expression of fra(10)(q25) in peripheral blood and bone marrow in familial neutropenia.

Authors: J A Holmes; P W Thompson
Journal: J Med Genet Date: 1988-04 Impact factor: 6.318

3. A BrdU-requiring fragile site on chromosome 12.

Authors: I Voiculescu; C Hausmann; G Wolff; E Back
Journal: Hum Genet Date: 1988-02 Impact factor: 4.132

4. Rare, polymorphic, and common fragile sites: a classification.

Authors: F Hecht
Journal: Hum Genet Date: 1986-10 Impact factor: 4.132

5. Inducing fragile sites to express themselves.

Authors: F Hecht; B Kaiser-McCaw
Journal: Am J Hum Genet Date: 1980-07 Impact factor: 11.025

6. Heritable fragile sites on human chromosomes. VI. Characterization of the fragile site at 12q13.

Authors: G R Sutherland; L Hinton
Journal: Hum Genet Date: 1981 Impact factor: 4.132

7. Fragile sites and structural rearrangements in cancer.

Authors: M De Braekeleer; B Smith; C C Lin
Journal: Hum Genet Date: 1985 Impact factor: 4.132

8. Fra(10)(q25): the BrdU effect is substitution-dependent.

Authors: S M Gollin; G P Holmquist; D H Ledbetter
Journal: Am J Hum Genet Date: 1985-01 Impact factor: 11.025

9. Evidence that sister chromatid exchanges and chromatid breaks are two independent events.

Authors: M S Lin; W Wertelecki
Journal: Chromosoma Date: 1982 Impact factor: 4.316

10. Spontaneous expression of the chromosome fragile site fra(10)(q25).

Authors: A M Taylor; S Bundey
Journal: Am J Hum Genet Date: 1983-01 Impact factor: 11.025