Literature DB >> 6823968

Spontaneous expression of the chromosome fragile site fra(10)(q25).

A M Taylor, S Bundey.   

Abstract

We report the spontaneous expression of the chromosome fragile site at 10q25 in a child with progressive cerebellar ataxia and in her phenotypically normal brother and father. Expression of this fragile site was increased in all three individuals by addition of bromodeoxyuridine (BrdU) to the medium. This fragile site has previously been described only following growth of cells in BrdU.

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Year:  1983        PMID： 6823968      PMCID： PMC1685496     

Source DB:  PubMed          Journal:  Am J Hum Genet        ISSN： 0002-9297            Impact factor:   11.025


  6 in total

1.  Heritable fragile sites on human chromosomes I. Factors affecting expression in lymphocyte culture.

Authors:  G R Sutherland
Journal:  Am J Hum Genet       Date:  1979-03       Impact factor: 11.025

2.  Heritable fragile sites on human chromosomes II. Distribution, phenotypic effects, and cytogenetics.

Authors:  G R Sutherland
Journal:  Am J Hum Genet       Date:  1979-03       Impact factor: 11.025

3.  Heritable fragile sites and lymphocyte culture medium containing BrdU.

Authors:  J M Scheres; T W Hustinx
Journal:  Am J Hum Genet       Date:  1980-07       Impact factor: 11.025

4.  Heritable fragile sites on human chromosomes. VII. Children homozygous for the BrdU-requiring fra(10)(q25) are phenotypically normal.

Authors:  G R Sutherland
Journal:  Am J Hum Genet       Date:  1981-11       Impact factor: 11.025

5.  Heritable fragile sites on human chromosomes. V. A new class of fragile site requiring BrdU for expression.

Authors:  G R Sutherland; E Baker; R S Seshadri
Journal:  Am J Hum Genet       Date:  1980-07       Impact factor: 11.025

6.  Familial spastic ataxia: occurrence in childhood.

Authors:  G W Hogan; M L Bauman
Journal:  Neurology       Date:  1977-06       Impact factor: 9.910
  6 in total
  4 in total

1.  Expression of fra(10)(q25) in peripheral blood and bone marrow in familial neutropenia.

Authors:  J A Holmes; P W Thompson
Journal:  J Med Genet       Date:  1988-04       Impact factor: 6.318

2.  A BrdU-requiring fragile site on chromosome 12.

Authors:  I Voiculescu; C Hausmann; G Wolff; E Back
Journal:  Hum Genet       Date:  1988-02       Impact factor: 4.132

3.  Fra(10)(q25): the BrdU effect is substitution-dependent.

Authors:  S M Gollin; G P Holmquist; D H Ledbetter
Journal:  Am J Hum Genet       Date:  1985-01       Impact factor: 11.025

4.  Heritable fragile sites on human chromosomes. XI. Factors affecting expression of fragile sites at 10q25, 16q22, and 17p12.

Authors:  G R Sutherland; P B Jacky; E G Baker
Journal:  Am J Hum Genet       Date:  1984-01       Impact factor: 11.025
  4 in total

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