Literature DB >> 3338802

A BrdU-requiring fragile site on chromosome 12.

I Voiculescu1, C Hausmann, G Wolff, E Back.   

Abstract

A BrdU-requiring fragile site, fra(12)(q24.2), on human chromosome 12 of some individuals is reported. This fragile site is inherited in a Mendelian codominant fashion and does not seem to be associated with any physical or mental abnormality in carriers. It was mostly observed as a chromatid gap: no acentric fragments, triradials or deleted chromosomes were found. The fra(12)(q24.2) was expressed in 34%-48% of metaphases in lymphocyte cultures from carriers when BrdU and FdU were added 6.5 h before harvest, while the expression ranged between 5% and 20% when the cultures were treated with BrdU alone. The fra(12)(q24.2) represents the second BrdU-requiring rare fragile site described on human chromosomes.

Entities:  

Mesh：

Substances：

Year:  1988        PMID： 3338802     DOI： 10.1007/bf00278193

Source DB:  PubMed          Journal:  Hum Genet        ISSN： 0340-6717            Impact factor:   4.132


  13 in total

1.  New classes of common fragile sites induced by 5-azacytidine and bromodeoxyuridine.

Authors:  G R Sutherland; M I Parslow; E Baker
Journal:  Hum Genet       Date:  1985       Impact factor: 4.132

2.  A heritable fragile 12q24.13 segregating in a family with the fragile X chromosome.

Authors:  A P Amarose; P R Huttenlocher; R M Sprudzs; T J Laitsch; M J Pettenati
Journal:  Hum Genet       Date:  1987-01       Impact factor: 4.132

3.  Rare, polymorphic, and common fragile sites: a classification.

Authors:  F Hecht
Journal:  Hum Genet       Date:  1986-10       Impact factor: 4.132

4.  Report of the Committee on Chromosome Rearrangements in Neoplasia and on Fragile Sites.

Authors:  R Berger; C D Bloomfield; G R Sutherland
Journal:  Cytogenet Cell Genet       Date:  1985

5.  Constitutional chromosomal breakage.

Authors:  F Giraud; S Ayme; J F Mattei; M G Mattei
Journal:  Hum Genet       Date:  1976-10-28       Impact factor: 4.132

6.  Heritable fragile sites on human chromosomes. VI. Characterization of the fragile site at 12q13.

Authors:  G R Sutherland; L Hinton
Journal:  Hum Genet       Date:  1981       Impact factor: 4.132

7.  Heritable fragile sites and lymphocyte culture medium containing BrdU.

Authors:  J M Scheres; T W Hustinx
Journal:  Am J Hum Genet       Date:  1980-07       Impact factor: 11.025

8.  Spontaneous expression of the chromosome fragile site fra(10)(q25).

Authors:  A M Taylor; S Bundey
Journal:  Am J Hum Genet       Date:  1983-01       Impact factor: 11.025

9.  Heritable fragile sites on human chromosomes. VII. Children homozygous for the BrdU-requiring fra(10)(q25) are phenotypically normal.

Authors:  G R Sutherland
Journal:  Am J Hum Genet       Date:  1981-11       Impact factor: 11.025

10.  Complete replacement of serum by albumin, transferrin, and soybean lipid in cultures of lipopolysaccharide-reactive B lymphocytes.

Authors:  N N Iscove; F Melchers
Journal:  J Exp Med       Date:  1978-03-01       Impact factor: 14.307
View more
  2 in total

1.  Homozygous condition for a BrdU-requiring fragile site on chromosome 12.

Authors:  I Voiculescu; E Back; W Schempp
Journal:  Hum Genet       Date:  1991-02       Impact factor: 4.132

Review 2.  Mosaicism for duplication 12q (12q13-->q24.2) in a dysmorphic male infant.

Authors:  J W Dixon; T Costa; I E Teshima
Journal:  J Med Genet       Date:  1993-01       Impact factor: 6.318
  2 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.