Literature DB >> 4342812

Analysis of ribosomes from viomycin-sensitive and -resistant strains of Mycobacterium smegmatis.

T Yamada, K Masuda, K Shoji, M Hori.   

Abstract

Viomycin-resistant strains were isolated from Mycobacterium smegmatis. Ribosomes were isolated and tested for drug resistance in subcellular systems containing poly(U) as messenger ribonucleic acid. Resistance to viomycin in these strains was due to altered ribosomes. Further analysis showed that viomycin resistance of two mutants with low level resistance (20 mug/ml) was due to altered 30S ribosomal subunits. Another mutant that was highly resistant to viomycin (1 mg/ml), however, had altered 50S ribosomal subunits.

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Year:  1972        PMID： 4342812      PMCID： PMC251373          DOI： 10.1128/jb.112.1.1-6.1972

Source DB:  PubMed          Journal:  J Bacteriol        ISSN： 0021-9193            Impact factor:   3.490


  19 in total

1.  Adenylylstreptomycin, a product of streptomycin inactivated by E. coli carrying R factor.

Authors:  H Umezawa; S Takasawa; M Okanishi; R Utahara
Journal:  J Antibiot (Tokyo)       Date:  1968-01       Impact factor: 2.649

2.  Chloramphenicol-, dihydrostreptomycin-, and kanamycin-inactivating enzymes from multiple drug-resistant Escherichia coli carrying episome 'R'.

Authors:  S Okamoto; Y Suzuki
Journal:  Nature       Date:  1965-12-25       Impact factor: 49.962

3.  Enzymatic inactivation of streptomycin by R factor-resistant Escherichia coli.

Authors:  T Yamada; D Tipper; J Davies
Journal:  Nature       Date:  1968-07-20       Impact factor: 49.962

4.  Effects of viomycin and polymyxin B on protein synthesis in vitro.

Authors:  N Tanaka; S Igusa
Journal:  J Antibiot (Tokyo)       Date:  1968-03       Impact factor: 2.649

5.  Antibiotic inhibitors of the bacterial ribosome.

Authors:  B Weisblum; J Davies
Journal:  Bacteriol Rev       Date:  1968-12

6.  Structure and function of ribosomes and their molecular components.

Authors:  M Nomura; S Mizushima; M Ozaki; P Traub; C V Lowry
Journal:  Cold Spring Harb Symp Quant Biol       Date:  1969

7.  Changes in ribosomal proteins associated with mutants in a locus that affects Escherichia coli ribosomes.

Authors:  J Krembel; D Apirion
Journal:  J Mol Biol       Date:  1968-04-28       Impact factor: 5.469

8.  Ribosomal protein conferring sensitivity to the antibiotic spectinomycin in Escherichia coli.

Authors:  A Bollen; J Davies; M Ozaki; S Mizushima
Journal:  Science       Date:  1968-07-04       Impact factor: 47.728

9.  Drastic alteration of ribosomal RNA and ribosomal proteins in showdomycin-resistant Escherichia coli.

Authors:  M Beljanski; P Bourgarel; M Beljanski
Journal:  Proc Natl Acad Sci U S A       Date:  1971-02       Impact factor: 11.205

10.  Erythromycin-resistant mutant of Escherichia coli with altered ribosomal protein component.

Authors:  K Tanaka; H Teraoka; M Tamaki; E Otaka; S Osawa
Journal:  Science       Date:  1968-11-01       Impact factor: 47.728
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  13 in total

1.  Viomycin favours the formation of 70S ribosome couples.

Authors:  T Yamada; K H Bierhaus
Journal:  Mol Gen Genet       Date:  1978-05-31

2.  Altered ribosomes in antibiotic-resistant mutants of Mycobacterium smegmatis.

Authors:  T Yamada; K Masuda; Y Mizuguchi; K Suga
Journal:  Antimicrob Agents Chemother       Date:  1976-05       Impact factor: 5.191

3.  Organization of rRNA genes in Mycobacterium bovis BCG.

Authors:  Y Suzuki; K Yoshinaga; Y Ono; A Nagata; T Yamada
Journal:  J Bacteriol       Date:  1987-02       Impact factor: 3.490

4.  Alteration of ribosomes and RNA polymerase in drug-resistant clinical isolates of Mycobacterium tuberculosis.

Authors:  T Yamada; A Nagata; Y Ono; Y Suzuki; T Yamanouchi
Journal:  Antimicrob Agents Chemother       Date:  1985-06       Impact factor: 5.191

5.  The translocation inhibitor tuberactinomycin binds to nucleic acids and blocks the in vitro assembly of 50S subunits.

Authors:  T Yamada; T Teshima; T Shiba; K H Nierhaus
Journal:  Nucleic Acids Res       Date:  1980-12-11       Impact factor: 16.971

6.  Ribosomal function and its inhibition by antibiotics in prokaryotes.

Authors:  K H Nierhaus; H G Wittmann
Journal:  Naturwissenschaften       Date:  1980-05

7.  Pleiotropic antibiotic resistance mutations associated with ribosomes and ribosomal subunits in Mycobacterium smegmatis.

Authors:  T Yamada; K Masuda; K Shoji; M Hori
Journal:  Antimicrob Agents Chemother       Date:  1974-07       Impact factor: 5.191

8.  Inhibition of the incorporation of 14C-precursors in Mycobacterium smegmatis by antibiotics and chemotherapeutics.

Authors:  V Majtán
Journal:  Folia Microbiol (Praha)       Date:  1982       Impact factor: 2.099

9.  Identification of the biosynthetic gene cluster and an additional gene for resistance to the antituberculosis drug capreomycin.

Authors:  Elizabeth A Felnagle; Michelle R Rondon; Andrew D Berti; Heidi A Crosby; Michael G Thomas
Journal:  Appl Environ Microbiol       Date:  2007-05-11       Impact factor: 4.792

10.  Activity of di-beta-lysyl-capreomycin IIA and palmitoyl tuberactinamine N against drug-resistant mutants with altered ribosomes.

Authors:  T Yamada; T Teshima; T Shiba
Journal:  Antimicrob Agents Chemother       Date:  1981-12       Impact factor: 5.191
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