Literature DB >> 182073

Altered ribosomes in antibiotic-resistant mutants of Mycobacterium smegmatis.

T Yamada, K Masuda, Y Mizuguchi, K Suga.   

Abstract

Two alleles for viomycin-capreomycin resistance (vic) in Mycobacterium smegmatis affect ribosome structures. One (vicA) affects a component of 50S subunits and the other (vicB) affects a component of 30S subunits. The locus for neomycin-kanamycin resistance (nek), which is linked to vicA and vicB, affects a component of 30S subunits. Although the erythromycin resistance locus (ery) is linked to vic and nek, no ribosomal alterations could be detected. Mutations at the streptomycin locus (str) not linked to vic and nek caused alterations of 30S subunits.

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Year:  1976        PMID： 182073      PMCID： PMC429627          DOI： 10.1128/AAC.9.5.817

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  33 in total

1.  A third kasugamycin resistance locus, ksgC, affecting ribosomal protein S2 in Escherichia coli K-12.

Authors:  M Yoshikawa; A Okuyama; N Tanaka
Journal:  J Bacteriol       Date:  1975-05       Impact factor: 3.490

2.  Streptomycin Resistance in Escherichia Coli Analyzed by Transduction.

Authors:  K Hashimoto
Journal:  Genetics       Date:  1960-01       Impact factor: 4.562

3.  Mapping of antibiotic resistance markers in Mycobacterium smegmatis.

Authors:  K Suga; Y Mizuguchi
Journal:  Jpn J Microbiol       Date:  1974-03

4.  Influence of the 50S ribosomal subunit on the ability of the 30S ribosomal subunit from Escherichia coli to bind dihydrostreptomycin.

Authors:  H Teraoka; K Tanaka
Journal:  Biochem Biophys Res Commun       Date:  1972-01-14       Impact factor: 3.575

Review 5.  The genetics of bacterial ribosomes.

Authors:  J Davies; M Nomura
Journal:  Annu Rev Genet       Date:  1972       Impact factor: 16.830

6.  Ribosomal proteins involved in the suppression of streptomycin dependence in Escherichia coli.

Authors:  G Kreider; B L Brownstein
Journal:  J Bacteriol       Date:  1972-02       Impact factor: 3.490

7.  Chromosomal location of antibiotic resistance markers in Bacillus subtilis.

Authors:  N Harford; N Sueoka
Journal:  J Mol Biol       Date:  1970-07-28       Impact factor: 5.469

8.  New chromosomal location for structural genes of ribosomal proteins.

Authors:  R J Watson; J Parker; N P Fiil; J G Flaks; J D Friesen
Journal:  Proc Natl Acad Sci U S A       Date:  1975-07       Impact factor: 11.205

9.  Genetic and biochemical studies on drug-resistant mutants in Mycobacterium smegmatis.

Authors:  Y Mizuguchi; K Suga; K Masuda; T Yamada
Journal:  Jpn J Microbiol       Date:  1974-11

10.  Pleiotropic antibiotic resistance mutations associated with ribosomes and ribosomal subunits in Mycobacterium smegmatis.

Authors:  T Yamada; K Masuda; K Shoji; M Hori
Journal:  Antimicrob Agents Chemother       Date:  1974-07       Impact factor: 5.191
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  7 in total

1.  Viomycin favours the formation of 70S ribosome couples.

Authors:  T Yamada; K H Bierhaus
Journal:  Mol Gen Genet       Date:  1978-05-31

2.  Detection of kanamycin-resistant Mycobacterium tuberculosis by identifying mutations in the 16S rRNA gene.

Authors:  Y Suzuki; C Katsukawa; A Tamaru; C Abe; M Makino; Y Mizuguchi; H Taniguchi
Journal:  J Clin Microbiol       Date:  1998-05       Impact factor: 5.948

3.  Alteration of ribosomes and RNA polymerase in drug-resistant clinical isolates of Mycobacterium tuberculosis.

Authors:  T Yamada; A Nagata; Y Ono; Y Suzuki; T Yamanouchi
Journal:  Antimicrob Agents Chemother       Date:  1985-06       Impact factor: 5.191

4.  The translocation inhibitor tuberactinomycin binds to nucleic acids and blocks the in vitro assembly of 50S subunits.

Authors:  T Yamada; T Teshima; T Shiba; K H Nierhaus
Journal:  Nucleic Acids Res       Date:  1980-12-11       Impact factor: 16.971

5.  Molecular analysis of kanamycin and viomycin resistance in Mycobacterium smegmatis by use of the conjugation system.

Authors:  H Taniguchi; B Chang; C Abe; Y Nikaido; Y Mizuguchi; S I Yoshida
Journal:  J Bacteriol       Date:  1997-08       Impact factor: 3.490

6.  Identification of the biosynthetic gene cluster and an additional gene for resistance to the antituberculosis drug capreomycin.

Authors:  Elizabeth A Felnagle; Michelle R Rondon; Andrew D Berti; Heidi A Crosby; Michael G Thomas
Journal:  Appl Environ Microbiol       Date:  2007-05-11       Impact factor: 4.792

7.  Activity of di-beta-lysyl-capreomycin IIA and palmitoyl tuberactinamine N against drug-resistant mutants with altered ribosomes.

Authors:  T Yamada; T Teshima; T Shiba
Journal:  Antimicrob Agents Chemother       Date:  1981-12       Impact factor: 5.191
  7 in total

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