Literature DB >> 3935045

In vitro activity of Ro 15-8074, a new oral cephalosporin, against Neisseria gonorrhoeae.

W S Ng, P Y Chau, Y K Leung, P C Wong.   

Abstract

Ro 15-8074, a new cephalosporin the pivaloyloxymethylester of which (Ro 15-8075) is orally absorbable, showed greater in vitro activity than cefaclor against 48 Neisseria gonorrhoeae strains, including 25 penicillinase-producing strains. Unlike cefaclor, Ro 15-8074 was unaffected by increase in inoculum size, and it exhibited a remarkable stability against gonococcal beta-lactamase hydrolysis.

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Year:  1985        PMID： 3935045      PMCID： PMC180277          DOI： 10.1128/AAC.28.3.461

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  9 in total

1.  Comparison of in vitro activity of cephalexin, cephradine, and cefaclor.

Authors:  N J Bill; J A Washington
Journal:  Antimicrob Agents Chemother       Date:  1977-03       Impact factor: 5.191

2.  In vitro antimicrobial susceptibilities of penicillinase-producing and non-penicillinase-producing strains of Neisseria gonorrhoeae isolated in Durban, South Africa.

Authors:  Y M Coovadia; U Ramsaroop
Journal:  Antimicrob Agents Chemother       Date:  1984-11       Impact factor: 5.191

3.  Susceptibility of Haemophilus influenzae type b to cefaclor and influence of inoculum size.

Authors:  R M Levin; P H Azimi; M G Dunphy
Journal:  Antimicrob Agents Chemother       Date:  1982-11       Impact factor: 5.191

4.  The efficacy of cefuroxime for the treatment of acute gonorrhoea in men.

Authors:  J D Price; J L Fluker
Journal:  Br J Vener Dis       Date:  1978-06

5.  HR 756--a new cephalosporin in the treatment of gonorrhoea caused by ordinary and penicillinase-producing strains of Neisseria gonorrhoeae.

Authors:  V S Rajan; E H Sng; R Pang; N J Tan; T Thirumoorthy; K L Yeo
Journal:  Br J Vener Dis       Date:  1980-08

6.  Novel method for detection of beta-lactamases by using a chromogenic cephalosporin substrate.

Authors:  C H O'Callaghan; A Morris; S M Kirby; A H Shingler
Journal:  Antimicrob Agents Chemother       Date:  1972-04       Impact factor: 5.191

7.  Neisseria gonorrhoeae strains isolated in Hong Kong: in vitro susceptibility to 13 antibiotics.

Authors:  W S Ng; P Anton; K Arnold
Journal:  Antimicrob Agents Chemother       Date:  1981-01       Impact factor: 5.191

8.  Single oral dose of cefaclor for the treatment of infections with penicillinase-producing strains of Neisseria gonorrhoeae.

Authors:  T E Tupasi; O V Calubiran; C A Torres
Journal:  Br J Vener Dis       Date:  1982-06

9.  In vitro antimicrobial activity of eight new beta-lactam antibiotics against penicillin-resistant Neisseria gonorrhoeae.

Authors:  S B Kerbs; J R Stone; S W Berg; W O Harrison
Journal:  Antimicrob Agents Chemother       Date:  1983-04       Impact factor: 5.191
  9 in total
  12 in total

1.  Comparative in vitro activity of the two new oral cephalosporin metabolites RO 19-5247 and RO 15-8074.

Authors:  K E Aldridge; D D Schiro; C V Sanders
Journal:  Eur J Clin Microbiol       Date:  1987-10       Impact factor: 3.267

2.  Preliminary antimicrobial susceptibility interpretive criteria for cefetamet (Ro 15-8074) and cefteram (Ro 19-5247) disk tests.

Authors:  R N Jones; A L Barry
Journal:  J Clin Microbiol       Date:  1987-09       Impact factor: 5.948

3.  Antimicrobial spectrum of Ro 15-8074/001, a new oral cephalosporin.

Authors:  M G Thomas; S D Lang
Journal:  Antimicrob Agents Chemother       Date:  1986-05       Impact factor: 5.191

4.  Antimicrobial activity of Ro 15-8074, active metabolite of a new oral cephalosporin (Ro 15-8075), against 7,775 recent clinical isolates.

Authors:  R N Jones; P C Fuchs; A L Barry; L W Ayers; E H Gerlach; T L Gavan
Journal:  Antimicrob Agents Chemother       Date:  1986-12       Impact factor: 5.191

5.  In vitro activity of Ro 15-8074 and Ro 19-5247 in comparison to cefaclor and cefalexin.

Authors:  C Simon
Journal:  Infection       Date:  1987 Mar-Apr       Impact factor: 3.553

Review 6.  Cefetamet pivoxil. A review of its antibacterial activity, pharmacokinetic properties and therapeutic use.

Authors:  H M Bryson; R N Brogden
Journal:  Drugs       Date:  1993-04       Impact factor: 9.546

Review 7.  Cefetamet pivoxil clinical pharmacokinetics.

Authors:  R A Blouin; K Stoeckel
Journal:  Clin Pharmacokinet       Date:  1993-09       Impact factor: 6.447

8.  In vitro activity of cefetamet (Ro 15-8074).

Authors:  H Mittermayer
Journal:  Eur J Clin Microbiol       Date:  1986-10       Impact factor: 3.267

9.  In vitro activity and beta-lactamase stability of two oral cephalosporins, ceftetrame (Ro 19-5247) and cefetamet (Ro 15-8074).

Authors:  H C Neu; N X Chin; P Labthavikul
Journal:  Antimicrob Agents Chemother       Date:  1986-09       Impact factor: 5.191

10.  In vitro activity of ceftriaxone, cefetamet (Ro 15-8074), ceftetrame (Ro 19-5247; T-2588), and fleroxacin (Ro 23-6240; AM-833) versus Neisseria gonorrhoeae and Haemophilus ducreyi.

Authors:  N M Le Saux; L A Slaney; F A Plummer; A R Ronald; R C Brunham
Journal:  Antimicrob Agents Chemother       Date:  1987-07       Impact factor: 5.191
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